DGIdb - CDK9 Gene Record

CDK9 1025 Druggable Genome

Alternate Names:

1025
CYCLIN DEPENDENT KINASE 9
CDK9
C-2k
CDC2L4
CTK1
PITALRE
TAK
603251
1780
ENSG00000136807
OTTHUMG00000020715
P50750
Tat-associated kinase complex catalytic subunit
Serine/threonine-protein kinase PITALRE
Cell division protein kinase 9
Cell division cycle 2-like protein kinase 4
Cyclin-dependent kinase 9
CDK9_HUMAN
CELL DIVISION PROTEIN KINASE 9 (EC 2.7.1.37) (CYCLIN-DEPENDENT KINASE 9) (SERINE/THREONINE-PROTEIN KINASE PITALRE) (C-2K) (CELL DIVISION CYCLE 2-LIKE PROTEIN KINASE 4). [SOURCE:UNIPROT/SWISSPROT;ACC:P50750]
CDK 1,2,4,5,6,7,9 (pan-CDK)
CDK 1,2,5,9
CDK 2,7,9
T44458
912

Gene Info:

Target Class	Enzymes
Target Subclass	EC:2.7.11.22
Target Subclass	2.7.11.23
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Human Readable Name	KINASE
Interpro Acc	IPR002290
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
CancerCommons Reported Gene Name	CDK1,2,5,9
CancerCommons Reported Gene Name	CDK2,7,9
CancerCommons Reported Gene Name	Pan CDK
Gene Biotype	PROTEIN_CODING

(12 More Sources)

Gene Categories: Category Details

TUMOR SUPPRESSOR
DNA REPAIR
KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Iurisci I et al., 2006, Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor., Cancer Res
Chen Z et al., 2016, Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity., Sci Rep
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Shao H et al., 2013, Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities., J Med Chem
Montagnoli A et al., 2008, A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity., Nat Chem Biol

RIVICICLIB CDK9

Interaction Score: 1.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD
DINACICLIB CDK9

Interaction Score: 1.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

PMIDs:
27378523

Sources:
MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions CIViC CancerCommons
CYC-065 CDK9

Interaction Score: 1.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
ALVOCIDIB CDK9

Interaction Score: 1.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

Direct Interaction yes

Trial Name flavopiridol, alvocidib, HMR-1275

PMIDs:
11752352 23301767 18469809

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions
BMS-387032 CDK9

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Trial Name SNS-032

Novel drug target Novel Target

PMIDs:
None found

Sources:
DTC TdgClinicalTrial ChemblInteractions CancerCommons TTD
DIPHENYLUREA CDK9

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SELICICLIB CDK9

Interaction Score: 0.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

Direct Interaction yes

Trial Name seliciclib, R-roscovitine, CYC202

PMIDs:
17108108

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions
RGB-286638 CDK9

Interaction Score: 0.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
ZOTIRACICLIB CDK9

Interaction Score: 0.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
(RS)-ROSCOVITINE CDK9

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACACETIN CDK9

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZD-5438 CDK9

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RONICICLIB CDK9

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
PHA-793887 CDK9

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AT-7519 CDK9

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL546797 CDK9

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL225519 CDK9

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18469809

Sources:
DTC
CHEMBL1997335 CDK9

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PALBOCICLIB CDK9

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALSTERPAULLONE CDK9

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
JNJ-7706621 CDK9

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 CDK9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000136807
- Version: 101_38
Alternate Names:

CDK9 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P50750
- Version: January-2014
Alternate Names:

CDK9 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.22

Target Subclass 2.7.11.23

Publications:
HopkinsGroom: P50750
- Version: 11-September-2012
Alternate Names:

1025 Entrez Gene Id

ENSG00000136807 Ensembl Gene Id

CDK9_HUMAN Uniprot Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Human Readable Name KINASE

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000136807

Version: 26-July-2011

Alternate Names:

ENSG00000136807 Ensembl Gene Id

CDK9 Display Id

CELL DIVISION PROTEIN KINASE 9 (EC 2.7.1.37) (CYCLIN-DEPENDENT KINASE 9) (SERINE/THREONINE-PROTEIN KINASE PITALRE) (C-2K) (CELL DIVISION CYCLE 2-LIKE PROTEIN KINASE 4). [SOURCE:UNIPROT/SWISSPROT;ACC:P50750] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

CancerCommons: CDK9
- Version: 25-July-2013
Alternate Names:

1025 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name CDK1,2,5,9

CancerCommons Reported Gene Name CDK2,7,9

CancerCommons Reported Gene Name Pan CDK

Publications:
CIViC: CDK9
- Version: 14-September-2020
Alternate Names:

1025 Entrez Gene ID

912 CIViC Gene ID

Gene Info:

Publications:

Chen Z et al., 2016, Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity., Sci Rep

DTC: CDK9

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Montagnoli A et al., 2008, A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity., Nat Chem Biol

Shao H et al., 2013, Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities., J Med Chem

HingoraniCasas: ENSG00000136807
- Version: 31-May-2017
Alternate Names:

ENSG00000136807 Gene Symbol

CDK9 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: CDK9
- Version: 20-Jun-2017
Alternate Names:

1025 Entrez Gene Id

CDK9 MyCancerGenome Gene Symbol

CDK 1,2,4,5,6,7,9 (pan-CDK) MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: CDC2L4
- Version: chembl_23
Alternate Names:

TAK GENE_SYMBOL

CDK9 GENE_SYMBOL

Cyclin-dependent kinase 9 UNIPROT

Gene Info:

Publications:
HumanProteinAtlas: CDK9
- Version: 19.3
Alternate Names:

ENSG00000136807 Ensembl Gene ID

C-2k Human Protein Atlas Gene Synonym

CDC2L4 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: CDK9
- Version: 01-February-2022
Alternate Names:

CDC2L4 GO Gene Synonym

TAK GO Gene Synonym

Gene Info:

Gene Categories:

TUMOR SUPPRESSOR, DNA REPAIR, SERINE THREONINE KINASE

Publications:
dGene: CDK9
- Version: 27-Jun-2013
Alternate Names:

1025 Gene ID

C-2k dGene Synonym

CDC2L4 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Cyclin-dependent kinase 9
- Version: 2020.06.01
Alternate Names:

CDK9 TTD Gene Abbreviation

T44458 TTD Target ID

Gene Info:

Publications:
Pharos: CDK9
- Version: 01-February-2022
Alternate Names:

Cyclin-dependent kinase 9 Gene Name

P50750 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
ClearityFoundationClinicalTrial: CDK9
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Cyclin-dependent kinase 9 inhibitor

Reported Cancer Type	Melanoma
Direct Interaction	yes
Mechanism of Interaction	Cyclin-dependent kinase 9 inhibitor

Reported Cancer Type	Melanoma
Trial Name	SNS-032
Novel drug target	Novel Target

Mechanism of Interaction	Cyclin-dependent kinase inhibitor
Direct Interaction	yes

1025	Entrez Gene Id
ENSG00000136807	Ensembl Gene Id
CDK9_HUMAN	Uniprot Id

TAK	GENE_SYMBOL
CDK9	GENE_SYMBOL
Cyclin-dependent kinase 9	UNIPROT

CDK9 Gene Record

CDK9 1025 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Melanoma Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

PMIDs: 27378523

Sources: MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions CIViC CancerCommons

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor Direct Interaction yes Trial Name flavopiridol, alvocidib, HMR-1275

PMIDs: 11752352 23301767 18469809

Sources: DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Melanoma Trial Name SNS-032 Novel drug target Novel Target

PMIDs: None found

Sources: DTC TdgClinicalTrial ChemblInteractions CancerCommons TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor Direct Interaction yes Trial Name seliciclib, R-roscovitine, CYC202

PMIDs: 17108108

Sources: MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18469809

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

PMIDs:
27378523

Sources:
MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions CIViC CancerCommons

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

Direct Interaction yes

Trial Name flavopiridol, alvocidib, HMR-1275

PMIDs:
11752352 23301767 18469809

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Trial Name SNS-032

Novel drug target Novel Target

PMIDs:
None found

Sources:
DTC TdgClinicalTrial ChemblInteractions CancerCommons TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

Direct Interaction yes

Trial Name seliciclib, R-roscovitine, CYC202

PMIDs:
17108108

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 9 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18469809

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CDK9 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CDK9 Gene Symbol