CXCR1 Gene Record

  • CXCR1 3577 Druggable Genome

    Alternate Names:

    3577
    C-X-C MOTIF CHEMOKINE RECEPTOR 1
    CXCR1
    C-C
    C-C-CKR-1
    CD128
    CD181
    CDw128a
    CKR-1
    CMKAR1
    IL8R1
    IL8RA
    IL8RBA
    146929
    6026
    ENSG00000163464
    OTTHUMG00000133108
    P25024
    C-X-C chemokine receptor type 1
    High affinity interleukin-8 receptor A
    IL-8 receptor type 1
    CD_antigen=CD181
    CXC-R1
    CXCR-1
    IL-8R A
    HIGH AFFINITY INTERLEUKIN-8 RECEPTOR A (IL-8R A) (IL-8 RECEPTOR TYPE 1) (CXCR-1) (CDW128A). [SOURCE:UNIPROT/SWISSPROT;ACC:P25024]
    CXCR1_HUMAN
    T00884

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Interpro Name GPCR, rhodopsin-like, 7TM
    Interpro Type Family
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

  • REPARIXIN   CXCR1

    Interaction Score: 12.37

    Interaction Types & Directionality:
    allosteric modulator
    modulator

    Interaction Info:
    Mechanism of Interaction Interleukin-8 receptor A modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • NAVARIXIN   CXCR1

    Interaction Score: 8.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name SCH-527123, PS-291822, PS-938285
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • NAVARIXIN   CXCR1

    Interaction Score: 6.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interleukin-8 receptor A antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LADARIXIN   CXCR1

    Interaction Score: 6.18

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Interleukin-8 receptor A modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IBUPROFEN   CXCR1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000163464

    • Version: 101_38

    Alternate Names:
    CXCR1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P25024

    • Version: January-2014

    Alternate Names:
    CXCR1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • RussLampel: ENSG00000163464

    • Version: 26-July-2011

    Alternate Names:
    IL8RA Display Id
    HIGH AFFINITY INTERLEUKIN-8 RECEPTOR A (IL-8R A) (IL-8 RECEPTOR TYPE 1) (CXCR-1) (CDW128A). [SOURCE:UNIPROT/SWISSPROT;ACC:P25024] Description
    ENSG00000163464 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P25024

    • Version: 11-September-2012

    Alternate Names:
    P25024 Uniprot Accession
    CXCR1 Uniprot Gene Name
    C-X-C CHEMOKINE RECEPTOR TYPE 1 Uniprot Protein Name

    Gene Info:
    Interpro Name GPCR, rhodopsin-like, 7TM
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Type Family

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • HingoraniCasas: ENSG00000163464

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000163464 Gene Symbol
    CXCR1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: CMKAR1

    • Version: chembl_23

    Alternate Names:
    IL8RA GENE_SYMBOL
    CXCR1 GENE_SYMBOL
    C-X-C chemokine receptor type 1 UNIPROT

    Gene Info:

    Publications:

  • GO: CXCR1

    • Version: 01-February-2022

    Alternate Names:
    CMKAR1 GO Gene Synonym
    IL8RA GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • dGene: CXCR1

    • Version: 27-Jun-2013

    Alternate Names:
    3577 Gene ID
    C-C dGene Synonym
    C-C-CKR-1 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: C-X-C chemokine receptor type 1

    • Version: 2020.06.01

    Alternate Names:
    CXCR1 TTD Gene Abbreviation
    T00884 TTD Target ID

    Gene Info:

    Publications: