2066 |
ERB-B2 RECEPTOR TYROSINE KINASE 4 |
ERBB4 |
ALS19 |
HER4 |
p180erbB4 |
600543 |
3432 |
ENSG00000178568 |
OTTHUMG00000133012 |
TYROSINE KINASE-TYPE CELL SURFACE RECEPTOR HER4 |
Q15303 |
ERBB4 intracellular domain |
Proto-oncogene-like protein c-ErbB-4 |
s80HER4 |
Receptor tyrosine-protein kinase erbB-4 |
4ICD |
E4ICD |
EGFR (HER1/ERBB1)HER2 (ERBB2/neu)HER4 (ERBB4) |
ERBB4_HUMAN |
RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 PRECURSOR (EC 2.7.1.112) (P180ERBB4) (TYROSINE KINASE-TYPE CELL SURFACE RECEPTOR HER4). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15303] |
1734 |
PA27847 |
Human Readable Name | KINASE |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Interpro Type | Domain |
Uniprot Status | Swiss-Prot |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR001245 |
Uniprot Evidence | 1: Evidence at protein level |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
Gene Biotype | PROTEIN_CODING |
KINASE |
TYROSINE KINASE |
DRUG RESISTANCE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
inhibitor (inhibitory) |
Trial Name | PF-299804 |
Novel drug target | Novel Target |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | AC480 |
Novel drug target | Novel Target |
Mechanism of Interaction | Receptor protein-tyrosine kinase erbB-4 inhibitor |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
Notes | |
Mechanism of Interaction | Receptor protein-tyrosine kinase erbB-4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Epidermal growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Receptor protein-tyrosine kinase erbB-4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Receptor protein-tyrosine kinase erbB-4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Epidermal growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Receptor protein-tyrosine kinase erbB-4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Epidermal growth factor receptor inhibitor |
Direct Interaction | yes |
ERBB4 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000178568 | Ensembl Gene Id |
RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 PRECURSOR (EC 2.7.1.112) (P180ERBB4) (TYROSINE KINASE-TYPE CELL SURFACE RECEPTOR HER4). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15303] | Description |
ERBB4 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
ERBB4 | Gene Symbol |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
ERBB4_HUMAN | Uniprot Id |
2066 | Entrez Gene Id |
RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 | Uniprot Protein Name |
Human Readable Name | KINASE |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
KINASE, DRUGGABLE GENOME |
2066 | CKB Entrez Id |
ERBB4 | CKB Gene Synonym |
ALS19 | CKB Gene Synonym |
PA27847 | PharmGKB ID |
2066 | Entrez Gene ID |
1734 | CIViC Gene ID |
DRUG RESISTANCE |
HER4 | Gene Symbol |
ENSG00000178568 | Gene Symbol |
ERBB4 | Ensembl Id |
DRUGGABLE GENOME |
HER4 | GENE_SYMBOL |
ERBB4 | GENE_SYMBOL |
Receptor tyrosine-protein kinase erbB-4 | UNIPROT |
2066 | Entrez Gene Id |
ERBB4 | MyCancerGenome Gene Symbol |
EGFR (HER1/ERBB1)HER2 (ERBB2/neu)HER4 (ERBB4) | MyCancerGenome Reported Gene Name |
HER4 | GO Gene Synonym |
TYROSINE KINASE |
ERBB4 | Gene Symbol |
CLINICALLY ACTIONABLE |
2066 | Gene ID |
HER4 | dGene Synonym |
p180erbB4 | dGene Synonym |
KINASE, TYROSINE KINASE |
Receptor tyrosine-protein kinase erbB-4 | Gene Name |
Q15303 | UniProt ID |
KINASE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |