DGIdb - GNRHR Gene Record

GNRHR 2798 Druggable Genome

Alternate Names:

2798
GONADOTROPIN RELEASING HORMONE RECEPTOR
GNRHR
GNRHR1
GRHR
HH7
LHRHR
LRHR
138850
4421
ENSG00000109163
OTTHUMG00000129302
P30968
GNRH RECEPTOR
GNRH-R
gonadotropin-releasing hormone receptor
GNRHR_HUMAN
GONADOTROPIN-RELEASING HORMONE RECEPTOR (GNRH RECEPTOR) (GNRH-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P30968]
T12475

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Subclass	Rhodopsin
Target Main Class	Receptors
Target Subclass	GPCR
Transmembrane Helix Count	7
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Target Class	Receptors
Uniprot Status	Swiss-Prot
Interpro Name	GPCR, rhodopsin-like, 7TM
Interpro Acc	IPR000276
Interpro Type	Family
Interpro Short Name	7TM_GPCR_Rhodpsn
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Bliss et al., 2007, Signaling complexes associated with the type I gonadotropin-releasing hormone (GnRH) receptor: colocalization of extracellularly regulated kinase 2 and GnRH receptor within membrane rafts., Mol. Endocrinol.
Lu et al., 2005, Mutations remote from the human gonadotropin-releasing hormone (GnRH) receptor-binding sites specifically increase binding affinity for GnRH II but not GnRH I: evidence for ligand-selective, receptor-active conformations., J. Biol. Chem.
Mamputha et al., 2007, Conserved amino acid residues that are important for ligand binding in the type I gonadotropin-releasing hormone (GnRH) receptor are required for high potency of GnRH II at the type II GnRH receptor., Mol. Endocrinol.
Moles et al., 2007, Temporal profile of brain and pituitary GnRHs, GnRH-R and gonadotropin mRNA expression and content during early development in European sea bass (Dicentrarchus labrax L.)., Gen. Comp. Endocrinol.
Lee et al., 2006, Gonadotropin-releasing hormone analog therapy for central precocious puberty and other childhood disorders affecting growth and puberty., Treat Endocrinol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Debruyne, 2004, Gonadotropin-releasing hormone antagonist in the management of prostate cancer., Rev Urol
Barbieri, 1990, Comparison of the pharmacology of nafarelin and danazol., Am. J. Obstet. Gynecol.
Saltiel et al., 1991, Pharmacologic management of endometriosis., Clin Pharm
Garner, 1994, Uses of GnRH agonists., J Obstet Gynecol Neonatal Nurs
Batzer, GnRH analogs: options for endometriosis-associated pain treatment., J Minim Invasive Gynecol
Chrisp et al., 1990, Nafarelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical potential in sex hormone-related conditions., Drugs
Hugues et al., Revisiting gonadotrophin-releasing hormone agonist protocols and management of poor ovarian responses to gonadotrophins., Hum. Reprod. Update
Letassy et al., 1990, Nafarelin acetate: a gonadotropin-releasing hormone agonist for the treatment of endometriosis., DICP
Valle et al., 2003, Endometriosis: treatment strategies., Ann. N. Y. Acad. Sci.
Suh et al., 2004, Dose of GnRH agonist (nafarelin acetate) affects intrafollicular PAPP-A expression in controlled ovarian hyperstimulation cycle., Eur. J. Obstet. Gynecol. Reprod. Biol.
Zapatero-Caballero et al., 2004, Gonadotropin-releasing hormone receptor gene expression during pubertal development of female rats., Biol. Reprod.
Roth et al., 2004, Pituitary and gonadal effects of GnRH (gonadotropin releasing hormone) analogues in two peripubertal female rat models., Pediatr. Res.
Völker et al., 2002, Expression of receptors for luteinizing hormone-releasing hormone in human ovarian and endometrial cancers: frequency, autoregulation, and correlation with direct antiproliferative activity of luteinizing hormone-releasing hormone analogues., Am. J. Obstet. Gynecol.
Castellón et al., Effect of leuprolide and cetrorelix on cell growth, apoptosis, and GnRH receptor expression in primary cell cultures from human prostate carcinoma., Cancer Invest.
Zapatero-Caballero et al., 2003, Gonadotropin-releasing hormone receptor gene expression during pubertal development of male rats., Biol. Reprod.
Oberyé et al., 2000, Local tolerance, pharmacokinetics, and dynamics of ganirelix (Orgalutran) administration by Medi-Jector compared to conventional needle injections., Hum. Reprod.
Steinberg, 2009, Degarelix: a gonadotropin-releasing hormone antagonist for the management of prostate cancer., Clin Ther
Samant et al., 2005, Synthesis and biological activity of GnRH antagonists modified at position 3 with 3-(2-methoxy-5-pyridyl)-alanine., J. Pept. Res.
Kirby et al., 2009, Abarelix and other gonadotrophin-releasing hormone antagonists in prostate cancer., BJU Int.
Anderson, 2009, Degarelix: a novel gonadotropin-releasing hormone blocker for the treatment of prostate cancer., Future Oncol
Borroni et al., 2000, Expression of GnRH receptor gene in human ectopic endometrial cells and inhibition of their proliferation by leuprolide acetate., Mol. Cell. Endocrinol.
Imai et al., 1998, Fas and Fas ligand system may mediate antiproliferative activity of gonadotropin-releasing hormone receptor in endometrial cancer cells., Int. J. Oncol.
Khurana et al., 1999, Maintenance of increased Bcl-2 expression in uterine leiomyomas after GnRH agonist therapy., J Reprod Med
Murase et al., 2005, GnRH antagonist-induced down-regulation of the mRNA expression of pituitary receptors: comparisons with GnRH agonist effects., Endocr. J.
Maya-Núñez et al., 2002, Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site., J. Clin. Endocrinol. Metab.
Tian et al., 2003, [Effect of Chinese herbal medicine for nourishing yin and purging fire on mRNA expressions of gonadotropin-releasing hormone and its receptor in precocious puberty model rats]., Zhongguo Zhong Xi Yi Jie He Za Zhi
Menon et al., 1986, Inhibition of gonadotropin-releasing hormone receptors in rat anterior pituitary monolayer cell cultures by danazol., Am. J. Obstet. Gynecol.
Dmowski, 1990, Danazol. A synthetic steroid with diverse biologic effects., J Reprod Med

NAFARELIN GNRHR

Interaction Score: 13.4

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2137975 1830521 7996307 17097577 2140979 9622415 2151003 11752352 14644830 14687742

Sources:
TdgClinicalTrial TEND TTD
GONADORELIN GNRHR

Interaction Score: 9.27

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17068198 15967801 16973761 16962597 17002488 11752352

Sources:
TdgClinicalTrial TEND TTD
DEGARELIX GNRHR

Interaction Score: 7.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Degarelix

PMIDs:
20110043 15705170 20053189 19450172

Sources:
TdgClinicalTrial TEND TTD
GANIRELIX ACETATE GNRHR

Interaction Score: 6.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

Direct Interaction yes

PMIDs:
10655292

Sources:
ChemblInteractions TTD
CETRORELIX GNRHR

Interaction Score: 6.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name cetrorelix,Cetrotide

Novel drug target Established target

PMIDs:
14561652 14605254 11854630 16809153 12606421 11752352

Sources:
TdgClinicalTrial TEND TTD
ABARELIX GNRHR

Interaction Score: 5.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name abarelix, Plenaxis

Direct Interaction yes

PMIDs:
16985933

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ZOPTARELIN DOXORUBICIN GNRHR

Interaction Score: 4.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
LINZAGOLIX GNRHR

Interaction Score: 4.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
BUSERELIN GNRHR

Interaction Score: 3.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
11994356 20053189

Sources:
NCI
OZARELIX GNRHR

Interaction Score: 3.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

Direct Interaction yes

Trial Name SPI-153, D-63153,Ozarelix

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
ELAGOLIX GNRHR

Interaction Score: 3.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

Direct Interaction yes

Trial Name NBI-56418

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
GOSERELIN ACETATE GNRHR

Interaction Score: 2.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OPIGOLIX GNRHR

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CETRORELIX ACETATE GNRHR

Interaction Score: 2.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GONADORELIN HYDROCHLORIDE GNRHR

Interaction Score: 2.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DEGARELIX ACETATE GNRHR

Interaction Score: 2.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRIPTORELIN PAMOATE GNRHR

Interaction Score: 2.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NAFARELIN ACETATE GNRHR

Interaction Score: 2.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HISTRELIN ACETATE GNRHR

Interaction Score: 2.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ACYLINE GNRHR

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SUFUGOLIX GNRHR

Interaction Score: 2.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RELUGOLIX GNRHR

Interaction Score: 2.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
LEUPROLIDE GNRHR

Interaction Score: 1.8

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Eligard

Novel drug target Established target

Trial Name leuprolide

PMIDs:
10687850 16809153 9625809 10394541 15758569

Sources:
TdgClinicalTrial TEND
EP-100 GNRHR

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name EP-100

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
GONADORELIN ACETATE GNRHR

Interaction Score: 1.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
LEUPROLIDE ACETATE GNRHR

Interaction Score: 1.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL179691 GNRHR

Interaction Score: 1.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name GnRH receptor antagonist, NBI-42902

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
HISTRELIN GNRHR

Interaction Score: 1.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name VP 002, histrelin implant,Vantas, Supprelin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
TRIPTORELIN GNRHR

Interaction Score: 1.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
TTD
DANAZOL GNRHR

Interaction Score: 0.77

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
14571621 3004220 14605254 2404115

Sources:
TdgClinicalTrial TEND

Ensembl: ENSG00000109163
- Version: 101_38
Alternate Names:

GNRHR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P30968
- Version: 01-August-2011
Alternate Names:

GNRHR Gene Symbol

ENSG00000109163 Ensembl Gene Id

P30968 Uniprot Accession

Gene Info:

Target Subclass Rhodopsin

Target Main Class Receptors

Target Subclass GPCR

Publications:
HopkinsGroom: P30968
- Version: 11-September-2012
Alternate Names:

2798 Entrez Gene Id

ENSG00000109163 Ensembl Gene Id

gonadotropin-releasing hormone receptor Uniprot Protein Name

Gene Info:

Uniprot Status Swiss-Prot

Interpro Name GPCR, rhodopsin-like, 7TM

Interpro Acc IPR000276

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000109163
- Version: 26-July-2011
Alternate Names:

ENSG00000109163 Ensembl Gene Id

GONADOTROPIN-RELEASING HORMONE RECEPTOR (GNRH RECEPTOR) (GNRH-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P30968] Description

GNRHR Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P30968
- Version: January-2014
Alternate Names:

GNRHR Gene Symbol

Gene Info:

Target Subclass Rhodopsin

Target Class Receptors

Target Subclass GPCR

Publications:
NCI: GNRHR
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Maya-Núñez et al., 2002, Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site., J. Clin. Endocrinol. Metab.
ChemblInteractions: GRHR
- Version: chembl_23
Alternate Names:

GRHR GENE_SYMBOL

GNRHR GENE_SYMBOL

Gonadotropin-releasing hormone receptor UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000109163
- Version: 31-May-2017
Alternate Names:

ENSG00000109163 Gene Symbol

GNRHR Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: GNRHR
- Version: 01-February-2022
Alternate Names:

GRHR GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: GNRHR
- Version: 27-Jun-2013
Alternate Names:

2798 Gene ID

GNRHR1 dGene Synonym

GRHR dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Gonadotropin-releasing hormone receptor
- Version: 2020.06.01
Alternate Names:

GNRHR TTD Gene Abbreviation

T12475 TTD Target ID

Gene Info:

Publications:
Pharos: GNRHR
- Version: 01-February-2022
Alternate Names:

Gonadotropin-releasing hormone receptor Gene Name

P30968 UniProt ID

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Mechanism of Interaction	Gonadotropin-releasing hormone receptor antagonist
Direct Interaction	yes

Trial Name	cetrorelix,Cetrotide
Novel drug target	Established target

Trial Name	Eligard
Novel drug target	Established target
Trial Name	leuprolide

Trial Name	GnRH receptor antagonist, NBI-42902
Novel drug target	Established target

Trial Name	VP 002, histrelin implant,Vantas, Supprelin
Novel drug target	Established target

GNRHR	Gene Symbol
ENSG00000109163	Ensembl Gene Id
P30968	Uniprot Accession

2798	Entrez Gene Id
ENSG00000109163	Ensembl Gene Id
gonadotropin-releasing hormone receptor	Uniprot Protein Name

GRHR	GENE_SYMBOL
GNRHR	GENE_SYMBOL
Gonadotropin-releasing hormone receptor	UNIPROT

Gonadotropin-releasing hormone receptor	Gene Name
P30968	UniProt ID

GNRHR Gene Record

GNRHR 2798 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 2137975 1830521 7996307 17097577 2140979 9622415 2151003 11752352 14644830 14687742

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17068198 15967801 16973761 16962597 17002488 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Degarelix

PMIDs: 20110043 15705170 20053189 19450172

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist Direct Interaction yes

PMIDs: 10655292

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name cetrorelix,Cetrotide Novel drug target Established target

PMIDs: 14561652 14605254 11854630 16809153 12606421 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name abarelix, Plenaxis Direct Interaction yes

PMIDs: 16985933

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 11994356 20053189

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist Direct Interaction yes Trial Name SPI-153, D-63153,Ozarelix

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist Direct Interaction yes Trial Name NBI-56418

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist Direct Interaction yes

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2137975 1830521 7996307 17097577 2140979 9622415 2151003 11752352 14644830 14687742

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17068198 15967801 16973761 16962597 17002488 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Degarelix

PMIDs:
20110043 15705170 20053189 19450172

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

Direct Interaction yes

PMIDs:
10655292

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name cetrorelix,Cetrotide

Novel drug target Established target

PMIDs:
14561652 14605254 11854630 16809153 12606421 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name abarelix, Plenaxis

Direct Interaction yes

PMIDs:
16985933

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

PMIDs:
11994356 20053189

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

Direct Interaction yes

Trial Name SPI-153, D-63153,Ozarelix

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

Direct Interaction yes

Trial Name NBI-56418

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Gonadotropin-releasing hormone receptor antagonist

Direct Interaction yes

PMIDs:
None found