DGIdb - GRM5 Gene Record

GRM5 2915 Druggable Genome

Alternate Names:

2915
GLUTAMATE METABOTROPIC RECEPTOR 5
GRM5
GPRC1E
MGLUR5
PPP1R86
mGlu5
604102
4597
ENSG00000168959
OTTHUMG00000134306
P41594
GRM5_HUMAN
Metabotropic glutamate receptor 5
METABOTROPIC GLUTAMATE RECEPTOR 5 PRECURSOR (MGLUR5). [SOURCE:UNIPROT/SWISSPROT;ACC:P41594]
T99347

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Glutamate
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Name	GPCR, family 3
Interpro Type	Family
Interpro Acc	IPR000337
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Short Name	GPCR_3
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Raboisson et al., 2012, Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development., Bioorg. Med. Chem. Lett.
Schroeder et al., 2005, The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats., Psychopharmacology (Berl.)
Baribeau DA et al., 2014, Social Communication is an Emerging Target for Pharmacotherapy in Autism Spectrum Disorder - A Review of the Literature on Potential Agents., J Can Acad Child Adolesc Psychiatry
Jacquemont S et al., 2014, The challenges of clinical trials in fragile X syndrome., Psychopharmacology (Berl)
De Witte et al., 2005, Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action., CNS Drugs

STX107 GRM5

Interaction Score: 19.02

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Metabotropic glutamate receptor 5 negative allosteric modulator

Trial Name STX107

PMIDs:
24516474

Sources:
TdgClinicalTrial ChemblInteractions TTD
BASIMGLURANT GRM5

Interaction Score: 14.27

Interaction Types & Directionality:

allosteric modulator

modulator

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 5 modulator

Direct Interaction yes

PMIDs:
24173622

Sources:
ChemblInteractions TTD
RASEGLURANT GRM5

Interaction Score: 14.27

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Metabotropic glutamate receptor 5 modulator

Trial Name ADX10059

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
MAVOGLURANT GRM5

Interaction Score: 9.51

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Metabotropic glutamate receptor 5 antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
AZD2066 GRM5

Interaction Score: 9.51

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 5 modulator

Direct Interaction yes

Trial Name AZD2066

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
RG7342 GRM5

Interaction Score: 9.51

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 5 modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
CHEMBL2164551 GRM5

Interaction Score: 9.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23046966

Sources:
DTC
CHEMBL2164552 GRM5

Interaction Score: 9.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23046966

Sources:
DTC
DIPRAGLURANT GRM5

Interaction Score: 9.51

Interaction Types & Directionality:

allosteric modulator

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Metabotropic glutamate receptor 5 modulator

PMIDs:
None found

Sources:
ChemblInteractions TTD
AZD2516 GRM5

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 5 negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LY545694 GRM5

Interaction Score: 4.76

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Metabotropic glutamate receptor 5 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
ACAMPROSATE GRM5

Interaction Score: 3.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name acamprosate,Campral

Novel drug target Established target

PMIDs:
15963001

Sources:
TdgClinicalTrial
ALCOHOL GRM5

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15717208

Sources:
NCI

Ensembl: ENSG00000168959
- Version: 101_38
Alternate Names:

GRM5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P41594
- Version: January-2014
Alternate Names:

GRM5 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Glutamate

Publications:
RussLampel: ENSG00000168959
- Version: 26-July-2011
Alternate Names:

ENSG00000168959 Ensembl Gene Id

METABOTROPIC GLUTAMATE RECEPTOR 5 PRECURSOR (MGLUR5). [SOURCE:UNIPROT/SWISSPROT;ACC:P41594] Description

GRM5 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P41594
- Version: 11-September-2012
Alternate Names:

ENSG00000168959 Ensembl Gene Id

2915 Entrez Gene Id

GRM5 Uniprot Gene Name

Gene Info:

Interpro Name GPCR, family 3

Interpro Type Family

Interpro Acc IPR000337

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

TTD: Metabotropic glutamate receptor 5

Version: 2020.06.01

Alternate Names:

mGluR5 TTD Gene Abbreviation

T99347 TTD Target ID

Gene Info:

Publications:

Jacquemont S et al., 2014, The challenges of clinical trials in fragile X syndrome., Psychopharmacology (Berl)

Baribeau DA et al., 2014, Social Communication is an Emerging Target for Pharmacotherapy in Autism Spectrum Disorder - A Review of the Literature on Potential Agents., J Can Acad Child Adolesc Psychiatry

NCI: GRM5

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Grassi et al., 2002, Different metabotropic glutamate receptors play opposite roles in synaptic plasticity of the rat medial vestibular nuclei., J. Physiol. (Lond.)

Cirone et al., 2002, Group I metabotropic glutamate receptors (mGluRs) modulate visual responses in the superficial superior colliculus of the rat., J. Physiol. (Lond.)

Schroeder et al., 2005, The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats., Psychopharmacology (Berl.)

DTC: GRM5
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Raboisson et al., 2012, Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development., Bioorg. Med. Chem. Lett.
HingoraniCasas: ENSG00000168959
- Version: 31-May-2017
Alternate Names:

ENSG00000168959 Gene Symbol

GRM5 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: GPRC1E
- Version: chembl_23
Alternate Names:

MGLUR5 GENE_SYMBOL

GRM5 GENE_SYMBOL

Metabotropic glutamate receptor 5 UNIPROT

Gene Info:

Publications:
GO: GRM5
- Version: 01-February-2022
Alternate Names:

GPRC1E GO Gene Synonym

MGLUR5 GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: GRM5
- Version: 27-Jun-2013
Alternate Names:

2915 Gene ID

GPRC1E dGene Synonym

MGLUR5 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Direct Interaction	yes
Mechanism of Interaction	Metabotropic glutamate receptor 5 negative allosteric modulator
Trial Name	STX107

Mechanism of Interaction	Metabotropic glutamate receptor 5 modulator
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Metabotropic glutamate receptor 5 antagonist

Trial Name	acamprosate,Campral
Novel drug target	Established target

ENSG00000168959	Ensembl Gene Id
METABOTROPIC GLUTAMATE RECEPTOR 5 PRECURSOR (MGLUR5). [SOURCE:UNIPROT/SWISSPROT;ACC:P41594]	Description
GRM5	Display Id

MGLUR5	GENE_SYMBOL
GRM5	GENE_SYMBOL
Metabotropic glutamate receptor 5	UNIPROT

GRM5 Gene Record

GRM5 2915 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Direct Interaction yes Mechanism of Interaction Metabotropic glutamate receptor 5 negative allosteric modulator Trial Name STX107

PMIDs: 24516474

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: allosteric modulator modulator

Interaction Info: Mechanism of Interaction Metabotropic glutamate receptor 5 modulator Direct Interaction yes

PMIDs: 24173622

Sources: ChemblInteractions TTD

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Metabotropic glutamate receptor 5 modulator Trial Name ADX10059

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Metabotropic glutamate receptor 5 antagonist

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Metabotropic glutamate receptor 5 modulator Direct Interaction yes Trial Name AZD2066

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Metabotropic glutamate receptor 5 modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23046966

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23046966

Sources: DTC

Interaction Types & Directionality: allosteric modulator modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Metabotropic glutamate receptor 5 modulator

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Metabotropic glutamate receptor 5 negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Metabotropic glutamate receptor 5 antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name acamprosate,Campral Novel drug target Established target

PMIDs: 15963001

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15717208

Sources: NCI

Ensembl: ENSG00000168959

Alternate Names: GRM5 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P41594

Alternate Names: GRM5 Gene Symbol

Gene Info: Target Class Receptors Target Subclass GPCR Target Subclass Glutamate

Publications:

RussLampel: ENSG00000168959

Alternate Names: ENSG00000168959 Ensembl Gene Id METABOTROPIC GLUTAMATE RECEPTOR 5 PRECURSOR (MGLUR5). [SOURCE:UNIPROT/SWISSPROT;ACC:P41594] Description GRM5 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P41594

Alternate Names: ENSG00000168959 Ensembl Gene Id 2915 Entrez Gene Id GRM5 Uniprot Gene Name

Gene Info: Interpro Name GPCR, family 3 Interpro Type Family Interpro Acc IPR000337

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

TTD: Metabotropic glutamate receptor 5

Alternate Names: mGluR5 TTD Gene Abbreviation T99347 TTD Target ID

Gene Info:

NCI: GRM5

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Metabotropic glutamate receptor 5 negative allosteric modulator

Trial Name STX107

PMIDs:
24516474

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

allosteric modulator

modulator

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 5 modulator

Direct Interaction yes

PMIDs:
24173622

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Metabotropic glutamate receptor 5 modulator

Trial Name ADX10059

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Metabotropic glutamate receptor 5 antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 5 modulator

Direct Interaction yes

Trial Name AZD2066

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 5 modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
23046966

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23046966

Sources:
DTC

Interaction Types & Directionality:

allosteric modulator

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Metabotropic glutamate receptor 5 modulator

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 5 negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Metabotropic glutamate receptor 5 antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name acamprosate,Campral

Novel drug target Established target

PMIDs:
15963001

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
15717208

Sources:
NCI

Alternate Names:

GRM5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

GRM5 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Glutamate

Alternate Names:

ENSG00000168959 Ensembl Gene Id

METABOTROPIC GLUTAMATE RECEPTOR 5 PRECURSOR (MGLUR5). [SOURCE:UNIPROT/SWISSPROT;ACC:P41594] Description

GRM5 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000168959 Ensembl Gene Id

2915 Entrez Gene Id

GRM5 Uniprot Gene Name

Gene Info:

Interpro Name GPCR, family 3

Interpro Type Family

Interpro Acc IPR000337

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

mGluR5 TTD Gene Abbreviation

T99347 TTD Target ID

Publications:

Raboisson et al., 2012, Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development., Bioorg. Med. Chem. Lett.

Alternate Names:

ENSG00000168959 Gene Symbol

GRM5 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MGLUR5 GENE_SYMBOL

GRM5 GENE_SYMBOL

Metabotropic glutamate receptor 5 UNIPROT

Alternate Names:

GPRC1E GO Gene Synonym

MGLUR5 GO Gene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

2915 Gene ID

GPRC1E dGene Synonym

MGLUR5 dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR