DGIdb - HSF1 Gene Record

HSF1 3297

Alternate Names:

3297
HEAT SHOCK TRANSCRIPTION FACTOR 1
HSF1
HSTF1
140580
5224
ENSG00000185122
OTTHUMG00000174604
Q00613
Heat shock factor protein 1

Gene Info:

Target Class	Miscellaneous
Target Subclass	HSP90-like_chaperon
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

DNA REPAIR
TRANSCRIPTION FACTOR

Publications:

Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem
Hargitai J et al., 2003, Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1., Biochem Biophys Res Commun

BIMOCLOMOL HSF1

Interaction Score: 41.22

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name bimoclomol, ABT-822

Novel drug target Novel Target

PMIDs:
12893279

Sources:
TdgClinicalTrial
CYCLOHEXIMIDE HSF1

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN HSF1

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19296652

Sources:
DTC

Ensembl: ENSG00000185122
- Version: 101_38
Alternate Names:

HSF1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q00613
- Version: January-2014
Alternate Names:

HSF1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass HSP90-like_chaperon

Publications:

NCI: HSF1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Shi et al., 1998, Molecular chaperones as HSF1-specific transcriptional repressors., Genes Dev.

Hung et al., 1998, Differential activation of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinases confers cadmium-induced HSP70 expression in 9L rat brain tumor cells., J. Biol. Chem.

DTC: HSF1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem
GO: HSF1
- Version: 01-February-2022
Alternate Names:

HSTF1 GO Gene Synonym

Gene Info:

Gene Categories:

DNA REPAIR

Publications:
Pharos: HSF1
- Version: 01-February-2022
Alternate Names:

Heat shock factor protein 1 Gene Name

Q00613 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:

Trial Name	bimoclomol, ABT-822
Novel drug target	Novel Target

HSF1 Gene Record

HSF1 3297

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

BIMOCLOMOL HSF1

Interaction Types & Directionality: n/a

Interaction Info: Trial Name bimoclomol, ABT-822 Novel drug target Novel Target

PMIDs: 12893279

Sources: TdgClinicalTrial

CYCLOHEXIMIDE HSF1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

QUERCETIN HSF1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19296652

Sources: DTC

Ensembl: ENSG00000185122

Alternate Names: HSF1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q00613

Alternate Names: HSF1 Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass HSP90-like_chaperon

Publications:

NCI: HSF1

Alternate Names:

Gene Info:

DTC: HSF1

Alternate Names:

Gene Info:

Publications: Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem

GO: HSF1

Alternate Names: HSTF1 GO Gene Synonym

Gene Info:

Gene Categories: DNA REPAIR

Publications:

Pharos: HSF1

Alternate Names: Heat shock factor protein 1 Gene Name Q00613 UniProt ID

Gene Info:

Gene Categories: TRANSCRIPTION FACTOR

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name bimoclomol, ABT-822

Novel drug target Novel Target

PMIDs:
12893279

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19296652

Sources:
DTC

Alternate Names:

HSF1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

HSF1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass HSP90-like_chaperon

Publications:

Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem

Alternate Names:

HSTF1 GO Gene Synonym

Gene Categories:

DNA REPAIR

Alternate Names:

Heat shock factor protein 1 Gene Name

Q00613 UniProt ID

Gene Categories:

TRANSCRIPTION FACTOR