DGIdb - IKBKB Gene Record

IKBKB 3551 Druggable Genome

Alternate Names:

3551
INHIBITOR OF NUCLEAR FACTOR KAPPA B KINASE SUBUNIT BETA
IKBKB
IKK-beta
IKK2
IKKB
IMD15
NFKBIKB
603258
5960
ENSG00000104365
OTTHUMG00000164092
O14920
IKKB_HUMAN
INHIBITOR OF NUCLEAR FACTOR KAPPA B KINASE BETA SUBUNIT (EC 2.7.1.37) (I-KAPPA-B-KINASE BETA) (IKBKB) (IKK-BETA) (IKK-B) (I-KAPPA-B KINASE 2) (IKK2) (NUCLEAR FACTOR NF-KAPPA-B INHIBITOR KINASE BETA) (NFKBIKB). [SOURCE:UNIPROT/SWISSPROT;ACC:O14920]
IKK-B
I-kappa-B-kinase beta
Nuclear factor NF-kappa-B inhibitor kinase beta
I-kappa-B kinase 2
Inhibitor of nuclear factor kappa-B kinase subunit beta
PA29776
Inhibitor of nuclear factor kappa-B kinase beta
T78429
IMD15A
IMD15B

Gene Info:

Target Subclass	2.7.11.10
Target Main Class	Enzymes
Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:2.7.11.10
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Nogueira L et al., 2011, The NFκB pathway: a therapeutic target in glioblastoma., Oncotarget
Folmer F et al., 2008, NF-kappaB-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus., J Nat Prod
Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem
Meragelman TL et al., 2009, Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa., J Nat Prod
Allgayer, 2003, Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease., Aliment. Pharmacol. Ther.
Bantel et al., 2000, Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis., Am. J. Gastroenterol.
Weber et al., 2000, Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta., Gastroenterology
Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J
Youn et al., 2006, Auranofin, as an anti-rheumatic gold compound, suppresses LPS-induced homodimerization of TLR4., Biochem. Biophys. Res. Commun.
Jeon et al., 2003, Gold compound auranofin inhibits IkappaB kinase (IKK) by modifying Cys-179 of IKKbeta subunit., Exp. Mol. Med.

AURANOFIN IKBKB

Interaction Score: 11.78

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17034761 12754408

Sources:
TdgClinicalTrial TEND
SAR-113945 IKBKB

Interaction Score: 8.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor

Direct Interaction yes

PMIDs:
21896960

Sources:
ChemblInteractions TTD
IMD-0354 IKBKB

Interaction Score: 5.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
R-RUGULACTONE IKBKB

Interaction Score: 5.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19093800

Sources:
DTC
IMD-1041 IKBKB

Interaction Score: 5.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD
MLN-0415 IKBKB

Interaction Score: 5.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MLN-0415

Novel drug target Established target

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
CHEMBL193093 IKBKB

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18702457

Sources:
DTC
IMD-2560 IKBKB

Interaction Score: 2.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL401565 IKBKB

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18088098

Sources:
DTC
CHEMBL256967 IKBKB

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18088098

Sources:
DTC
AS-602868 IKBKB

Interaction Score: 1.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NORHARMANE IKBKB

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PARTHENOLIDE IKBKB

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BMS-345541 IKBKB

Interaction Score: 0.65

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

PMIDs:
18702457

Sources:
DTC
MESALAMINE IKBKB

Interaction Score: 0.59

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name SPD476,Lialda

Novel drug target Established target

PMIDs:
12950415 11151876 11054378

Sources:
TdgClinicalTrial
BARDOXOLONE METHYL IKBKB

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TAK-715 IKBKB

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL578061 IKBKB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
STAUROSPORINE IKBKB

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GEFITINIB IKBKB

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31664190

Sources:
PharmGKB
ALSTERPAULLONE IKBKB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000104365
- Version: 101_38
Alternate Names:

IKBKB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: O14920
- Version: 01-August-2011
Alternate Names:

O14920 Uniprot Accession

IKBKB Gene Symbol

3551 Entrez Gene Id

Gene Info:

Target Subclass 2.7.11.10

Target Main Class Enzymes

Publications:
TdgClinicalTrial: O14920
- Version: January-2014
Alternate Names:

IKBKB Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.10

Publications:

RussLampel: ENSG00000104365

Version: 26-July-2011

Alternate Names:

INHIBITOR OF NUCLEAR FACTOR KAPPA B KINASE BETA SUBUNIT (EC 2.7.1.37) (I-KAPPA-B-KINASE BETA) (IKBKB) (IKK-BETA) (IKK-B) (I-KAPPA-B KINASE 2) (IKK2) (NUCLEAR FACTOR NF-KAPPA-B INHIBITOR KINASE BETA) (NFKBIKB). [SOURCE:UNIPROT/SWISSPROT;ACC:O14920] Description

ENSG00000104365 Ensembl Gene Id

IKBKB Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: IKBKB
- Version: 18-August-2020
Alternate Names:

PA29776 PharmGKB ID

Gene Info:

Publications:

Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J
TTD: Inhibitor of nuclear factor kappa-B kinase beta
- Version: 2020.06.01
Alternate Names:

IKKB TTD Gene Abbreviation

T78429 TTD Target ID

Gene Info:

Publications:

Nogueira L et al., 2011, The NFκB pathway: a therapeutic target in glioblastoma., Oncotarget

DTC: IKBKB

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Meragelman TL et al., 2009, Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa., J Nat Prod

Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem

Folmer F et al., 2008, NF-kappaB-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus., J Nat Prod

HingoraniCasas: ENSG00000104365
- Version: 31-May-2017
Alternate Names:

ENSG00000104365 Gene Symbol

IKBKB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: IKKB
- Version: chembl_23
Alternate Names:

IKK-beta UNIPROT

IkBKB UNIPROT

IKKB GENE_SYMBOL

Gene Info:

Publications:
GO: IKBKB
- Version: 01-February-2022
Alternate Names:

IKKB GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: IKBKB
- Version: 27-Jun-2013
Alternate Names:

3551 Gene ID

IKK-beta dGene Synonym

IKK2 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
Pharos: IKBKB
- Version: 01-February-2022
Alternate Names:

Inhibitor of nuclear factor kappa-B kinase subunit beta Gene Name

O14920 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:

Mechanism of Interaction	Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor
Direct Interaction	yes

Trial Name	MLN-0415
Novel drug target	Established target
Direct Interaction	yes

INHIBITOR OF NUCLEAR FACTOR KAPPA B KINASE BETA SUBUNIT (EC 2.7.1.37) (I-KAPPA-B-KINASE BETA) (IKBKB) (IKK-BETA) (IKK-B) (I-KAPPA-B KINASE 2) (IKK2) (NUCLEAR FACTOR NF-KAPPA-B INHIBITOR KINASE BETA) (NFKBIKB). [SOURCE:UNIPROT/SWISSPROT;ACC:O14920]	Description
ENSG00000104365	Ensembl Gene Id
IKBKB	Display Id

Inhibitor of nuclear factor kappa-B kinase subunit beta	Gene Name
O14920	UniProt ID

IKBKB Gene Record

IKBKB 3551 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17034761 12754408

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor Direct Interaction yes

PMIDs: 21896960

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19093800

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MLN-0415 Novel drug target Established target Direct Interaction yes

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18702457

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18088098

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18088098

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: allosteric modulator

Interaction Info:

PMIDs: 18702457

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name SPD476,Lialda Novel drug target Established target

PMIDs: 12950415 11151876 11054378

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17034761 12754408

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor

Direct Interaction yes

PMIDs:
21896960

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
19093800

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MLN-0415

Novel drug target Established target

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
18702457

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
18088098

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18088098

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

allosteric modulator

PMIDs:
18702457

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name SPD476,Lialda

Novel drug target Established target

PMIDs:
12950415 11151876 11054378

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
31664190

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

IKBKB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

O14920 Uniprot Accession

IKBKB Gene Symbol

3551 Entrez Gene Id

Gene Info:

Target Subclass 2.7.11.10

Target Main Class Enzymes

Alternate Names:

IKBKB Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.10

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME