DGIdb - KCNMA1 Gene Record

KCNMA1 3778 Druggable Genome

Alternate Names:

3778
POTASSIUM CALCIUM-ACTIVATED CHANNEL SUBFAMILY M ALPHA 1
KCNMA1
BKTM
CADEDS
KCa1.1
MaxiK
PNKD3
SAKCA
SLO
SLO-ALPHA
SLO1
bA205K10.1
hSlo
mSLO1
600150
6284
ENSG00000156113
OTTHUMG00000018543
KCNMA
Maxi K channel
Calcium-activated potassium channel subunit alpha-1
BK channel
BKCA alpha
Calcium-activated potassium channel, subfamily M subunit alpha-1
K(VCA)alpha
Slowpoke homolog
Slo homolog
Q12791
CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT 1 (CALCIUM-ACTIVATED POTASSIUM CHANNEL, SUBFAMILY M, ALPHA SUBUNIT 1) (MAXI K CHANNEL) (MAXIK) (BK CHANNEL) (K(VCA)ALPHA) (BKCA ALPHA) (KCA1.1) (SLOWPOKE HOMOLOG) (SLO HOMOLOG) (SLO-ALPHA) (SLO1) (HSLO). [
KCMA1_HUMAN
Calcium-activated potassium channel KCa1.1
T66538
IEG16
LIWAS

Gene Info:

Target Class	Transporters
Target Subclass	TC:1.A.1.3
Human Readable Name	DRUGGABLE GENOME
Initial Gene Query	Kca1.1
Counted Citations from 1950-2000	1035
Uniprot Status	Swiss-Prot
Interpro Short Name	Ion_trans_dom
Interpro Name	Ion transport domain
Interpro Acc	IPR005821
Interpro Type	Domain
Human Readable Name	ION CHANNEL
Uniprot Evidence	1: Evidence at protein level
Target Subclass	Ca_Activated_Potassium_Channels
Target Subclass	Voltage_gated_ion_channels
Transmembrane Helix Count	8
Target Main Class	Transporters
Target Subclass	Channels
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Syme et al., 2000, Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels., Am. J. Physiol., Cell Physiol.
Dong et al., 2006, Chlorzoxazone inhibits contraction of rat thoracic aorta., Eur. J. Pharmacol.
Alviña et al., 2010, KCa channels as therapeutic targets in episodic ataxia type-2., J. Neurosci.

BMS-223131 KCNMA1

Interaction Score: 7.73

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Calcium-activated potassium channel subunit alpha-1 activator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHLORZOXAZONE KCNMA1

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10712246 16859676 20505091

Sources:
TdgClinicalTrial TEND
ANDOLAST KCNMA1

Interaction Score: 3.86

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Calcium-activated potassium channel subunit alpha-1 activator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CROMOLYN KCNMA1

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
TRICHLORMETHIAZIDE KCNMA1

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
FLINDOKALNER KCNMA1

Interaction Score: 1.55

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Calcium-activated potassium channel subunit alpha-1 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHLOROTHIAZIDE KCNMA1

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
ENFLURANE KCNMA1

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Ensembl: ENSG00000156113
- Version: 101_38
Alternate Names:

KCNMA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q12791
- Version: 11-September-2012
Alternate Names:

KCMA1_HUMAN Uniprot Id

KCNMA1 Uniprot Gene Name

ENSG00000156113 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Ion_trans_dom

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000156113

Version: 26-July-2011

Alternate Names:

ENSG00000156113 Ensembl Gene Id

KCNMA1 Display Id

CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT 1 (CALCIUM-ACTIVATED POTASSIUM CHANNEL, SUBFAMILY M, ALPHA SUBUNIT 1) (MAXI K CHANNEL) (MAXIK) (BK CHANNEL) (K(VCA)ALPHA) (BKCA ALPHA) (KCA1.1) (SLOWPOKE HOMOLOG) (SLO HOMOLOG) (SLO-ALPHA) (SLO1) (HSLO). [ Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

BaderLabGenes: KCNMA1
- Version: February-2014
Alternate Names:

3778 Entrez Gene ID

Gene Info:

Initial Gene Query Kca1.1

Counted Citations from 1950-2000 1035

Gene Categories:

ION CHANNEL

Publications:
TdgClinicalTrial: Q12791
- Version: January-2014
Alternate Names:

KCNMA1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.3

Publications:
TEND: Q12791
- Version: 01-August-2011
Alternate Names:

ENSG00000156113 Ensembl Gene Id

3778 Entrez Gene Id

KCMA1_HUMAN Uniprot Id

Gene Info:

Target Subclass Ca_Activated_Potassium_Channels

Target Subclass Voltage_gated_ion_channels

Transmembrane Helix Count 8

Publications:
HingoraniCasas: ENSG00000156113
- Version: 31-May-2017
Alternate Names:

ENSG00000156113 Gene Symbol

KCNMA1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: KCNMA
- Version: chembl_23
Alternate Names:

SLO GENE_SYMBOL

KCNMA1 GENE_SYMBOL

Calcium-activated potassium channel subunit alpha-1 UNIPROT

Gene Info:

Publications:
TTD: Calcium-activated potassium channel KCa1.1
- Version: 2020.06.01
Alternate Names:

KCNMA1 TTD Gene Abbreviation

T66538 TTD Target ID

Gene Info:

Publications:
Pharos: KCNMA1
- Version: 01-February-2022
Alternate Names:

Calcium-activated potassium channel subunit alpha-1 Gene Name

Q12791 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Mechanism of Interaction	Calcium-activated potassium channel subunit alpha-1 activator
Direct Interaction	yes

KCMA1_HUMAN	Uniprot Id
KCNMA1	Uniprot Gene Name
ENSG00000156113	Ensembl Gene Id

SLO	GENE_SYMBOL
KCNMA1	GENE_SYMBOL
Calcium-activated potassium channel subunit alpha-1	UNIPROT

Calcium-activated potassium channel subunit alpha-1	Gene Name
Q12791	UniProt ID

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

KCNMA1 Gene Record

KCNMA1 3778 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: activator (activating)

Interaction Info: Mechanism of Interaction Calcium-activated potassium channel subunit alpha-1 activator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10712246 16859676 20505091

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: activator (activating)

Interaction Info: Mechanism of Interaction Calcium-activated potassium channel subunit alpha-1 activator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: activator (activating)

Interaction Info: Mechanism of Interaction Calcium-activated potassium channel subunit alpha-1 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Ensembl: ENSG00000156113

Alternate Names: KCNMA1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: Q12791

Alternate Names: KCMA1_HUMAN Uniprot Id KCNMA1 Uniprot Gene Name ENSG00000156113 Ensembl Gene Id

Gene Info: Uniprot Status Swiss-Prot Human Readable Name DRUGGABLE GENOME Interpro Short Name Ion_trans_dom

Gene Categories: ION CHANNEL, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000156113

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

BaderLabGenes: KCNMA1

Alternate Names: 3778 Entrez Gene ID

Gene Info: Initial Gene Query Kca1.1 Counted Citations from 1950-2000 1035

Gene Categories: ION CHANNEL

Publications:

TdgClinicalTrial: Q12791

Alternate Names: KCNMA1 Gene Symbol

Gene Info: Target Class Transporters Target Subclass TC:1.A.1.3

Publications:

TEND: Q12791

Alternate Names: ENSG00000156113 Ensembl Gene Id 3778 Entrez Gene Id KCMA1_HUMAN Uniprot Id

Gene Info: Target Subclass Ca_Activated_Potassium_Channels Target Subclass Voltage_gated_ion_channels Transmembrane Helix Count 8

Publications:

HingoraniCasas: ENSG00000156113

Alternate Names: ENSG00000156113 Gene Symbol KCNMA1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: KCNMA

Alternate Names: SLO GENE_SYMBOL KCNMA1 GENE_SYMBOL Calcium-activated potassium channel subunit alpha-1 UNIPROT

Gene Info:

Publications:

TTD: Calcium-activated potassium channel KCa1.1

Alternate Names: KCNMA1 TTD Gene Abbreviation T66538 TTD Target ID

Gene Info:

Publications:

Pharos: KCNMA1

Alternate Names: Calcium-activated potassium channel subunit alpha-1 Gene Name Q12791 UniProt ID

Gene Info:

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Calcium-activated potassium channel subunit alpha-1 activator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10712246 16859676 20505091

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Calcium-activated potassium channel subunit alpha-1 activator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Calcium-activated potassium channel subunit alpha-1 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Alternate Names:

KCNMA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

KCMA1_HUMAN Uniprot Id

KCNMA1 Uniprot Gene Name

ENSG00000156113 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Ion_trans_dom

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

3778 Entrez Gene ID

Gene Info:

Initial Gene Query Kca1.1

Counted Citations from 1950-2000 1035

Gene Categories:

ION CHANNEL

Alternate Names:

KCNMA1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.3

Alternate Names:

ENSG00000156113 Ensembl Gene Id

3778 Entrez Gene Id

KCMA1_HUMAN Uniprot Id

Gene Info:

Target Subclass Ca_Activated_Potassium_Channels

Target Subclass Voltage_gated_ion_channels

Transmembrane Helix Count 8

Alternate Names:

ENSG00000156113 Gene Symbol

KCNMA1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SLO GENE_SYMBOL

KCNMA1 GENE_SYMBOL

Calcium-activated potassium channel subunit alpha-1 UNIPROT

Alternate Names:

KCNMA1 TTD Gene Abbreviation

T66538 TTD Target ID

Alternate Names:

Calcium-activated potassium channel subunit alpha-1 Gene Name

Q12791 UniProt ID

Gene Categories:

ION CHANNEL