MAP4K2 Gene Record

  • MAP4K2 5871 Druggable Genome

    Alternate Names:

    5871
    MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 2
    MAP4K2
    BL44
    GCK
    RAB8IP
    603166
    6864
    ENSG00000168067
    OTTHUMG00000045328
    Q12851
    M4K2_HUMAN
    MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 2 (EC 2.7.1.37) (MAPK/ERK KINASE KINASE KINASE 2) (MEK KINASE KINASE 2) (MEKKK 2) (GERMINAL CENTER KINASE) (GC KINASE) (RAB8 INTERACTING PROTEIN) (B LYMPHOCYTE SERINE/THREONINE-PROTEIN KINASE). [SOURCE
    MEK kinase kinase 2
    T07191

    Gene Info:

    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR002290
    Human Readable Name KINASE
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME

    Publications:

  • CHEMBL117217   MAP4K2

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL535331   MAP4K2

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZD-1152-HQPA   MAP4K2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AST-487   MAP4K2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL541400   MAP4K2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1997335   MAP4K2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OSI-632   MAP4K2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL379975   MAP4K2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DACTOLISIB   MAP4K2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CEDIRANIB   MAP4K2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PALBOCICLIB   MAP4K2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • JNJ-7706621   MAP4K2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALSTERPAULLONE   MAP4K2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PD-0166285   MAP4K2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ENTRECTINIB   MAP4K2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW441756X   MAP4K2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL225519   MAP4K2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LINIFANIB   MAP4K2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RG-1530   MAP4K2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOVITINIB   MAP4K2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SP-600125   MAP4K2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYC-116   MAP4K2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TAE-684   MAP4K2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   MAP4K2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ILORASERTIB   MAP4K2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CENISERTIB   MAP4K2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000168067

    • Version: 101_38

    Alternate Names:
    MAP4K2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000168067

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000168067 Ensembl Gene Id
    MAP4K2 Display Id
    MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 2 (EC 2.7.1.37) (MAPK/ERK KINASE KINASE KINASE 2) (MEK KINASE KINASE 2) (MEKKK 2) (GERMINAL CENTER KINASE) (GC KINASE) (RAB8 INTERACTING PROTEIN) (B LYMPHOCYTE SERINE/THREONINE-PROTEIN KINASE). [SOURCE Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q12851

    • Version: 11-September-2012

    Alternate Names:
    MAP4K2 Uniprot Gene Name
    Q12851 Uniprot Accession
    ENSG00000168067 Ensembl Gene Id

    Gene Info:
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • HingoraniCasas: ENSG00000168067

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000168067 Gene Symbol
    MAP4K2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: MAP4K2

    • Version: 01-February-2022

    Alternate Names:
    GCK GO Gene Synonym
    RAB8IP GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • dGene: MAP4K2

    • Version: 27-Jun-2013

    Alternate Names:
    5871 Gene ID
    BL44 dGene Synonym
    GCK dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: MEK kinase kinase 2

    • Version: 2020.06.01

    Alternate Names:
    MAP4K2 TTD Gene Abbreviation
    T07191 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: MAP4K2

    • Version: 01-February-2022

    Alternate Names:
    Mitogen-activated protein kinase kinase kinase kinase 2 Gene Name
    Q12851 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • DTC: MAP4K2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications: