MAP4K4 Gene Record

  • MAP4K4 9448 Druggable Genome

    Alternate Names:

    9448
    MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4
    MAP4K4
    FLH21957
    HEL-S-31
    HGK
    MEKKK4
    NIK
    604666
    6866
    ENSG00000071054
    OTTHUMG00000155394
    O95819
    MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4 (EC 2.7.1.37) (MAPK/ERK KINASE KINASE KINASE 4) (MEK KINASE KINASE 4) (MEKKK 4) (HPK/GCK-LIKE KINASE HGK) (NCK INTERACTING KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:O95819]
    M4K4_HUMAN
    PA30612
    MEK kinase kinase 4
    T71367
    KIAA0687

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Human Readable Name KINASE
    Interpro Acc IPR002290
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME

    Publications:

  • CEP-1347   MAP4K4

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044867


    Sources:
    DTC

  • SB-242235   MAP4K4

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL375293   MAP4K4

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • R-1487   MAP4K4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL535331   MAP4K4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ANASTROZOLE   MAP4K4

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • EXEMESTANE   MAP4K4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DORAMAPIMOD   MAP4K4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZD-1152-HQPA   MAP4K4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TAK-715   MAP4K4

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SB-203580   MAP4K4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ADAVOSERTIB   MAP4K4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FASUDIL   MAP4K4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SB-220025   MAP4K4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SB-202190   MAP4K4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AST-487   MAP4K4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL541400   MAP4K4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW843682X   MAP4K4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PAZOPANIB   MAP4K4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1997335   MAP4K4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OSI-632   MAP4K4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PALBOCICLIB   MAP4K4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CEDIRANIB   MAP4K4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALSTERPAULLONE   MAP4K4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PD-0166285   MAP4K4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • VANDETANIB   MAP4K4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SOTRASTAURIN   MAP4K4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ENTRECTINIB   MAP4K4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW441756X   MAP4K4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GEFITINIB   MAP4K4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOVITINIB   MAP4K4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SP-600125   MAP4K4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYC-116   MAP4K4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TAE-684   MAP4K4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   MAP4K4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ILORASERTIB   MAP4K4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CENISERTIB   MAP4K4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000071054

    • Version: 101_38

    Alternate Names:
    MAP4K4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000071054

    • Version: 26-July-2011

    Alternate Names:
    MAP4K4 Display Id
    MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4 (EC 2.7.1.37) (MAPK/ERK KINASE KINASE KINASE 4) (MEK KINASE KINASE 4) (MEKKK 4) (HPK/GCK-LIKE KINASE HGK) (NCK INTERACTING KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:O95819] Description
    ENSG00000071054 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: O95819

    • Version: 11-September-2012

    Alternate Names:
    M4K4_HUMAN Uniprot Id
    O95819 Uniprot Accession
    mitogen-activated protein kinase kinase kinase kinase 4 Uniprot Protein Name

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Human Readable Name KINASE

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • DTC: MAP4K4

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Goodfellow VS et al., 2013, Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3., J Med Chem

  • HingoraniCasas: ENSG00000071054

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000071054 Gene Symbol
    MAP4K4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: MAP4K4

    • Version: 18-August-2020

    Alternate Names:
    PA30612 PharmGKB ID

    Gene Info:

    Publications:

  • GO: MAP4K4

    • Version: 01-February-2022

    Alternate Names:
    HGK GO Gene Synonym
    KIAA0687 GO Gene Synonym
    NIK GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • dGene: MAP4K4

    • Version: 27-Jun-2013

    Alternate Names:
    9448 Gene ID
    FLH21957 dGene Synonym
    HGK dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: MEK kinase kinase 4

    • Version: 2020.06.01

    Alternate Names:
    MAP4K4 TTD Gene Abbreviation
    T71367 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: MAP4K4

    • Version: 01-February-2022

    Alternate Names:
    Mitogen-activated protein kinase kinase kinase kinase 4 Gene Name
    O95819 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications: