DGIdb - MAPKAPK2 Gene Record

MAPKAPK2 9261 Druggable Genome

Alternate Names:

9261
MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE 2
MAPKAPK2
MAPKAP-K2
MK-2
MK2
602006
6887
ENSG00000162889
OTTHUMG00000036342
P49137
MAPK2_HUMAN
MAP KINASE-ACTIVATED PROTEIN KINASE 2
MAPKAPK-2
MAPKAP kinase 2
MAPK-activated protein kinase 2
MAP KINASE-ACTIVATED PROTEIN KINASE 2 (EC 2.7.1.-) (MAPK-ACTIVATED PROTEIN KINASE 2) (MAPKAP KINASE 2) (MAPKAPK-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P49137]
MAPK activated protein kinase 2
T21307

Gene Info:

Interpro Type	Domain
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Uniprot Status	Swiss-Prot
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Interpro Acc	IPR002290
Human Readable Name	KINASE
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME

Publications:

Nakano et al., 2000, Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: evidence for involvement of p38 MAPK., Circ. Res.
Davis et al., 2007, Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells., Bioorg. Med. Chem. Lett.

CBP-501 MAPKAPK2

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
AT-13148 MAPKAPK2

Interaction Score: 1.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase-activated protein kinase 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THEOPHYLLINE MAPKAPK2

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10666409

Sources:
NCI
SB-203580 MAPKAPK2

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17964780

Sources:
DTC
LAUROGUADINE MAPKAPK2

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL225519 MAPKAPK2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000162889
- Version: 101_38
Alternate Names:

MAPKAPK2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000162889

Version: 26-July-2011

Alternate Names:

MAPKAPK2 Display Id

ENSG00000162889 Ensembl Gene Id

MAP KINASE-ACTIVATED PROTEIN KINASE 2 (EC 2.7.1.-) (MAPK-ACTIVATED PROTEIN KINASE 2) (MAPKAP KINASE 2) (MAPKAPK-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P49137] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P49137
- Version: 11-September-2012
Alternate Names:

P49137 Uniprot Accession

9261 Entrez Gene Id

MAPK2_HUMAN Uniprot Id

Gene Info:

Interpro Type Domain

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
NCI: MAPKAPK2
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Nakano et al., 2000, Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: evidence for involvement of p38 MAPK., Circ. Res.
DTC: MAPKAPK2
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Davis et al., 2007, Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells., Bioorg. Med. Chem. Lett.
HingoraniCasas: ENSG00000162889
- Version: 31-May-2017
Alternate Names:

ENSG00000162889 Gene Symbol

MAPKAPK2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: MAPKAPK2
- Version: chembl_23
Alternate Names:

MAPKAP kinase 2 UNIPROT

MAPKAPK2 GENE_SYMBOL

MAP kinase-activated protein kinase 2 UNIPROT

Gene Info:

Publications:
dGene: MAPKAPK2
- Version: 27-Jun-2013
Alternate Names:

9261 Gene ID

MAPKAP-K2 dGene Synonym

MK-2 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: MAPK-activated protein kinase 2
- Version: 2020.06.01
Alternate Names:

MAPKAPK2 TTD Gene Abbreviation

T21307 TTD Target ID

Gene Info:

Publications:
Pharos: MAPKAPK2
- Version: 01-February-2022
Alternate Names:

MAP kinase-activated protein kinase 2 Gene Name

P49137 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: MAPKAPK2
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:

Mechanism of Interaction	MAP kinase-activated protein kinase 2 inhibitor
Direct Interaction	yes

MAPKAPK2	Display Id
ENSG00000162889	Ensembl Gene Id
MAP KINASE-ACTIVATED PROTEIN KINASE 2 (EC 2.7.1.-) (MAPK-ACTIVATED PROTEIN KINASE 2) (MAPKAP KINASE 2) (MAPKAPK-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P49137]	Description

P49137	Uniprot Accession
9261	Entrez Gene Id
MAPK2_HUMAN	Uniprot Id

MAPKAP kinase 2	UNIPROT
MAPKAPK2	GENE_SYMBOL
MAP kinase-activated protein kinase 2	UNIPROT

MAP kinase-activated protein kinase 2	Gene Name
P49137	UniProt ID

MAPKAPK2 Gene Record

MAPKAPK2 9261 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CBP-501 MAPKAPK2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

AT-13148 MAPKAPK2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase-activated protein kinase 2 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

THEOPHYLLINE MAPKAPK2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10666409

Sources: NCI

SB-203580 MAPKAPK2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17964780

Sources: DTC

LAUROGUADINE MAPKAPK2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

CHEMBL225519 MAPKAPK2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Ensembl: ENSG00000162889

Alternate Names: MAPKAPK2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000162889

Alternate Names: MAPKAPK2 Display Id ENSG00000162889 Ensembl Gene Id MAP KINASE-ACTIVATED PROTEIN KINASE 2 (EC 2.7.1.-) (MAPK-ACTIVATED PROTEIN KINASE 2) (MAPKAP KINASE 2) (MAPKAPK-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P49137] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P49137

Alternate Names: P49137 Uniprot Accession 9261 Entrez Gene Id MAPK2_HUMAN Uniprot Id

Gene Info: Interpro Type Domain Human Readable Name DRUGGABLE GENOME Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Gene Categories: KINASE, DRUGGABLE GENOME

Publications:

NCI: MAPKAPK2

Alternate Names:

Gene Info:

Publications: Nakano et al., 2000, Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: evidence for involvement of p38 MAPK., Circ. Res.

DTC: MAPKAPK2

Alternate Names:

Gene Info:

Publications: Davis et al., 2007, Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells., Bioorg. Med. Chem. Lett.

HingoraniCasas: ENSG00000162889

Alternate Names: ENSG00000162889 Gene Symbol MAPKAPK2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: MAPKAPK2

Alternate Names: MAPKAP kinase 2 UNIPROT MAPKAPK2 GENE_SYMBOL MAP kinase-activated protein kinase 2 UNIPROT

Gene Info:

Publications:

dGene: MAPKAPK2

Alternate Names: 9261 Gene ID MAPKAP-K2 dGene Synonym MK-2 dGene Synonym

Gene Info:

Gene Categories: KINASE, SERINE THREONINE KINASE

Publications:

TTD: MAPK-activated protein kinase 2

Alternate Names: MAPKAPK2 TTD Gene Abbreviation T21307 TTD Target ID

Gene Info:

Publications:

Pharos: MAPKAPK2

Alternate Names: MAP kinase-activated protein kinase 2 Gene Name P49137 UniProt ID

Gene Info:

Gene Categories: KINASE

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase-activated protein kinase 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
10666409

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17964780

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

MAPKAPK2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

MAPKAPK2 Display Id

ENSG00000162889 Ensembl Gene Id

MAP KINASE-ACTIVATED PROTEIN KINASE 2 (EC 2.7.1.-) (MAPK-ACTIVATED PROTEIN KINASE 2) (MAPKAP KINASE 2) (MAPKAPK-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P49137] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

P49137 Uniprot Accession

9261 Entrez Gene Id

MAPK2_HUMAN Uniprot Id

Gene Info:

Interpro Type Domain

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

Nakano et al., 2000, Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: evidence for involvement of p38 MAPK., Circ. Res.

Publications:

Davis et al., 2007, Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells., Bioorg. Med. Chem. Lett.

Alternate Names:

ENSG00000162889 Gene Symbol

MAPKAPK2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MAPKAP kinase 2 UNIPROT

MAPKAPK2 GENE_SYMBOL

MAP kinase-activated protein kinase 2 UNIPROT

Alternate Names:

9261 Gene ID

MAPKAP-K2 dGene Synonym

MK-2 dGene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE

Alternate Names:

MAPKAPK2 TTD Gene Abbreviation

T21307 TTD Target ID

Alternate Names:

MAP kinase-activated protein kinase 2 Gene Name

P49137 UniProt ID

Gene Categories:

KINASE

Gene Categories:

SERINE THREONINE KINASE