DGIdb - MC1R Gene Record

MC1R 4157 Druggable Genome

Alternate Names:

4157
MELANOCORTIN 1 RECEPTOR
MC1R
CMM5
MSH-R
SHEP2
155555
6929
ENSG00000258839
OTTHUMG00000171163
Q01726
MSHR
MC1-R
Melanocortin receptor 1
Melanocyte-stimulating hormone receptor
PA30673
ENSG00000198211
MSHR_HUMAN
AC092143.1
T35842

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Name	GPCR, rhodopsin-like, 7TM
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Acc	IPR000276
Interpro Short Name	7TM_GPCR_Rhodpsn
Uniprot Status	Swiss-Prot
Target Subclass	Rhodopsin
Target Class	Receptors
Target Subclass	GPCR
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Fitzgerald et al., 2006, Effect of MELANOTAN, [Nle(4), D-Phe(7)]-alpha-MSH, on melanin synthesis in humans with MC1R variant alleles., Peptides
Minder EI et al., 2017, Pharmacokinetics and Pharmacodynamics of Afamelanotide and its Clinical Use in Treating Dermatologic Disorders., Clin Pharmacokinet
Balwani M, 2019, Erythropoietic Protoporphyria and X-Linked Protoporphyria: pathophysiology, genetics, clinical manifestations, and management., Mol Genet Metab
Kim ES et al., 2016, Afamelanotide: A Review in Erythropoietic Protoporphyria., Am J Clin Dermatol
Wu GS et al., 2011, Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response., Psychiatr Genet

AFAMELANOTIDE MC1R

Interaction Score: 92.74

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Novel Target

Trial Name Afamelanotide

PMIDs:
16293341 28063031 30704898 26979527

Sources:
TdgClinicalTrial TTD
MODIMELANOTIDE MC1R

Interaction Score: 7.73

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Melanocortin receptor 1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BREMELANOTIDE MC1R

Interaction Score: 7.73

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Melanocortin receptor 1 agonist

Direct Interaction yes

Trial Name Bremelanotide

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
DESIPRAMINE MC1R

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21052032

Sources:
PharmGKB

Ensembl: ENSG00000198211
- Version: 101_38
Alternate Names:

AC092143.1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
Ensembl: ENSG00000258839
- Version: 101_38
Alternate Names:

MC1R Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q01726
- Version: 11-September-2012
Alternate Names:

Q01726 Uniprot Accession

4157 Entrez Gene Id

MC1R Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Name GPCR, rhodopsin-like, 7TM

Interpro Type Family

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q01726
- Version: January-2014
Alternate Names:

MC1R Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
PharmGKB: MC1R
- Version: 18-August-2020
Alternate Names:

PA30673 PharmGKB ID

Gene Info:

Publications:

Wu GS et al., 2011, Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response., Psychiatr Genet
HingoraniCasas: ENSG00000258839
- Version: 31-May-2017
Alternate Names:

ENSG00000258839 Gene Symbol

MC1R Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: MSHR
- Version: chembl_23
Alternate Names:

MSHR GENE_SYMBOL

MC1R GENE_SYMBOL

Melanocyte-stimulating hormone receptor UNIPROT

Gene Info:

Publications:
HumanProteinAtlas: MC1R
- Version: 19.3
Alternate Names:

ENSG00000258839 Ensembl Gene ID

MSH-R Human Protein Atlas Gene Synonym

Melanocortin 1 receptor Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
GO: MC1R
- Version: 01-February-2022
Alternate Names:

MSHR GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
Tempus: MC1R
- Version: 11-November-2018
Alternate Names:

MC1R Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: MC1R
- Version: 27-Jun-2013
Alternate Names:

4157 Gene ID

CMM5 dGene Synonym

MSH-R dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Melanocortin receptor 1
- Version: 2020.06.01
Alternate Names:

MC1R TTD Gene Abbreviation

T35842 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Melanocortin receptor 1 agonist
Direct Interaction	yes

Q01726	Uniprot Accession
4157	Entrez Gene Id
MC1R	Uniprot Gene Name

MSHR	GENE_SYMBOL
MC1R	GENE_SYMBOL
Melanocyte-stimulating hormone receptor	UNIPROT

ENSG00000258839	Ensembl Gene ID
MSH-R	Human Protein Atlas Gene Synonym
Melanocortin 1 receptor	Human Protein Atlas Gene Description

Novel drug target	Novel Target
Trial Name	Afamelanotide

MC1R Gene Record

MC1R 4157 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

AFAMELANOTIDE MC1R

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Novel Target Trial Name Afamelanotide

PMIDs: 16293341 28063031 30704898 26979527

Sources: TdgClinicalTrial TTD

MODIMELANOTIDE MC1R

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Melanocortin receptor 1 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

BREMELANOTIDE MC1R

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Melanocortin receptor 1 agonist Direct Interaction yes Trial Name Bremelanotide

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

DESIPRAMINE MC1R

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21052032

Sources: PharmGKB

Ensembl: ENSG00000198211

Alternate Names: AC092143.1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

Ensembl: ENSG00000258839

Alternate Names: MC1R Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: Q01726

Alternate Names: Q01726 Uniprot Accession 4157 Entrez Gene Id MC1R Uniprot Gene Name

Gene Info: Human Readable Name DRUGGABLE GENOME Interpro Name GPCR, rhodopsin-like, 7TM Interpro Type Family

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

TdgClinicalTrial: Q01726

Alternate Names: MC1R Gene Symbol

Gene Info: Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin

Publications:

PharmGKB: MC1R

Alternate Names: PA30673 PharmGKB ID

Gene Info:

Publications: Wu GS et al., 2011, Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response., Psychiatr Genet

HingoraniCasas: ENSG00000258839

Alternate Names: ENSG00000258839 Gene Symbol MC1R Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: MSHR

Alternate Names: MSHR GENE_SYMBOL MC1R GENE_SYMBOL Melanocyte-stimulating hormone receptor UNIPROT

Gene Info:

Publications:

HumanProteinAtlas: MC1R

Alternate Names: ENSG00000258839 Ensembl Gene ID MSH-R Human Protein Atlas Gene Synonym Melanocortin 1 receptor Human Protein Atlas Gene Description

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

GO: MC1R

Alternate Names: MSHR GO Gene Synonym

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

Tempus: MC1R

Alternate Names: MC1R Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

dGene: MC1R

Alternate Names: 4157 Gene ID CMM5 dGene Synonym MSH-R dGene Synonym

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

TTD: Melanocortin receptor 1

Alternate Names: MC1R TTD Gene Abbreviation T35842 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Novel Target

Trial Name Afamelanotide

PMIDs:
16293341 28063031 30704898 26979527

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Melanocortin receptor 1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Melanocortin receptor 1 agonist

Direct Interaction yes

Trial Name Bremelanotide

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
21052032

Sources:
PharmGKB

Alternate Names:

AC092143.1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

MC1R Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

Q01726 Uniprot Accession

4157 Entrez Gene Id

MC1R Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Name GPCR, rhodopsin-like, 7TM

Interpro Type Family

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

MC1R Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

PA30673 PharmGKB ID

Publications:

Wu GS et al., 2011, Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response., Psychiatr Genet

Alternate Names:

ENSG00000258839 Gene Symbol

MC1R Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MSHR GENE_SYMBOL

MC1R GENE_SYMBOL

Melanocyte-stimulating hormone receptor UNIPROT

Alternate Names:

ENSG00000258839 Ensembl Gene ID

MSH-R Human Protein Atlas Gene Synonym

Melanocortin 1 receptor Human Protein Atlas Gene Description

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

MSHR GO Gene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

MC1R Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

4157 Gene ID

CMM5 dGene Synonym

MSH-R dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

MC1R TTD Gene Abbreviation

T35842 TTD Target ID