142 |
POLY(ADP-RIBOSE) POLYMERASE 1 |
PARP1 |
ADPRT |
ADPRT 1 |
ADPRT1 |
ARTD1 |
PARP |
PARP-1 |
PPOL |
pADPRT-1 |
173870 |
270 |
ENSG00000143799 |
OTTHUMG00000037556 |
POLY [ADP-RIBOSE] POLYMERASE-1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-RIBOSYLTRANSFERASE-1) (POLY[ADP-RIBOSE] SYNTHETASE-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P09874] |
P09874 |
POLY [ADP-RIBOSE] POLYMERASE 1 |
PARP1_HUMAN |
Poly[ADP-ribose] synthase 1 |
NAD(+) ADP-ribosyltransferase 1 |
ADP-ribosyltransferase diphtheria toxin-like 1 |
199 |
PA32 |
T06273 |
PARS |
Poly-PARP |
Human Readable Name | DRUGGABLE GENOME |
CancerCommons Reported Gene Name | PARP |
Interpro Name | Poly(ADP-ribose) polymerase, catalytic domain |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Acc | IPR012317 |
Uniprot Status | Swiss-Prot |
Interpro Short Name | Poly(ADP-ribose)pol_cat_dom |
Interpro Type | Domain |
Target Class | Enzymes |
Target Subclass | EC:2.4.2.30 |
Gene Biotype | PROTEIN_CODING |
TRANSCRIPTION FACTOR COMPLEX |
DNA REPAIR |
DRUG RESISTANCE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
ENZYME |
TRANSCRIPTION FACTOR |
inhibitor (inhibitory) |
Notes | |
Trial Name | iniparib, SAR240550, BSI-201 |
Novel drug target | Novel Target |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | PARP 1, 2 and 3 inhibitor |
Reported Cancer Type | Prostate |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Poly [ADP-ribose] polymerase-1 inhibitor |
Trial Name | MK-4827 |
inhibitor (inhibitory) |
Mechanism of Interaction | Poly [ADP-ribose] polymerase-1 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | PARP 1, 2 & 3 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | PARP 1, 2 and 3 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Poly [ADP-ribose] polymerase-1 inhibitor |
Direct Interaction | yes |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Notes | |
Mechanism of Interaction | PARP 1, 2 and 3 inhibitor |
Direct Interaction | yes |
PARP1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
POLY [ADP-RIBOSE] POLYMERASE-1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-RIBOSYLTRANSFERASE-1) (POLY[ADP-RIBOSE] SYNTHETASE-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P09874] | Description |
PARP1 | Display Id |
ENSG00000143799 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
ENSG00000143799 | Ensembl Gene Id |
PARP1 | Uniprot Gene Name |
142 | Entrez Gene Id |
Interpro Name | Poly(ADP-ribose) polymerase, catalytic domain |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Acc | IPR012317 |
DRUGGABLE GENOME |
142 | Entrez Gene ID |
CancerCommons Reported Gene Name | PARP |
PARP1 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.4.2.30 |
142 | Entrez Gene ID |
199 | CIViC Gene ID |
DRUG RESISTANCE |
ENSG00000143799 | Gene Symbol |
PARP1 | Ensembl Id |
DRUGGABLE GENOME |
142 | Entrez Gene Id |
PARP1 | MyCancerGenome Gene Symbol |
PARP | MyCancerGenome Reported Gene Name |
PPOL | GENE_SYMBOL |
PARP1 | GENE_SYMBOL |
Poly [ADP-ribose] polymerase 1 | UNIPROT |
PARP-1 | Gene Symbol |
PA32 | PharmGKB ID |
ADPRT | GO Gene Synonym |
PPOL | GO Gene Synonym |
TRANSCRIPTION FACTOR COMPLEX, DNA REPAIR |
PARP1 | TTD Gene Abbreviation |
T06273 | TTD Target ID |
Poly [ADP-ribose] polymerase 1 | Gene Name |
P09874 | UniProt ID |
ENZYME, TRANSCRIPTION FACTOR |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |