5742 |
PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 1 |
PTGS1 |
COX1 |
COX3 |
PCOX1 |
PES-1 |
PGG/HS |
PGHS-1 |
PGHS1 |
PHS1 |
PTGHS |
176805 |
9604 |
ENSG00000095303 |
OTTHUMG00000020605 |
PA24346 |
Prostaglandin G/H synthase 1 |
Cyclooxygenase-1 |
Prostaglandin H2 synthase 1 |
COX-1 |
PGH synthase 1 |
PHS 1 |
P23219 |
PGH1_HUMAN |
PROSTAGLANDIN G/H SYNTHASE 1 PRECURSOR (EC 1.14.99.1) (CYCLOOXYGENASE- 1) (COX-1) (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 1) (PROSTAGLANDIN H2 SYNTHASE 1) (PGH SYNTHASE 1) (PGHS-1) (PHS 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P23219] |
T60529 |
Target Subclass | 1.14.99.1 |
Target Main Class | Enzymes |
Target Class | Enzymes |
Target Subclass | EC:1.14.99.1 |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR002007 |
Interpro Short Name | Haem_peroxidase_animal |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Family |
Uniprot Status | Swiss-Prot |
Interpro Name | Haem peroxidase, animal |
Gene Biotype | PROTEIN_CODING |
DRUGGABLE GENOME |
ENZYME |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
Trial Name | - |
inhibitor (inhibitory) |
Trial Name | Bromfenac |
Novel drug target | Established target |
Trial Name | ISV-101 |
inhibitor (inhibitory) |
Trial Name | ketoprofen in Transfersome gel, IDEA-033,Diractin |
Novel drug target | Established target |
Trial Name | ketoprofen transdermal patch, EN3269 |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
Trial Name | - |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
Trial Name | CRx-401 |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
Trial Name | Naproxcinod |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
n/a |
Trial Name | VB-201 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Trial Name | MT 100 |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Trial Name | HZT-501, ibuprofen + famotidine,Duexa |
Novel drug target | Established target |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Trial Name | transdermal diclofenac |
Trial Name | PRO-571, diclofenac potassium |
Trial Name | NanoEmulsion (diclofenac) |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | MAX-002 |
Novel drug target | Established target |
Trial Name | mesalamine,Pentasa, Canasa, Asacol |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
n/a |
Novel drug target | Established target |
Trial Name | dersalazine sodium |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Trial Name | PTI-701 |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
PTGS1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
PGH1_HUMAN | Uniprot Id |
PTGS1 | Gene Symbol |
5742 | Entrez Gene Id |
Target Subclass | 1.14.99.1 |
Target Main Class | Enzymes |
PROSTAGLANDIN G/H SYNTHASE 1 PRECURSOR (EC 1.14.99.1) (CYCLOOXYGENASE- 1) (COX-1) (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 1) (PROSTAGLANDIN H2 SYNTHASE 1) (PGH SYNTHASE 1) (PGHS-1) (PHS 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P23219] | Description |
ENSG00000095303 | Ensembl Gene Id |
PTGS1 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
ENSG00000095303 | Ensembl Gene Id |
PTGS1 | Uniprot Gene Name |
PGH1_HUMAN | Uniprot Id |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR002007 |
Interpro Short Name | Haem_peroxidase_animal |
DRUGGABLE GENOME |
PTGS1 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:1.14.99.1 |
PA24346 | PharmGKB ID |
COX-1 | TTD Gene Abbreviation |
T60529 | TTD Target ID |
COX1 | GENE_SYMBOL |
PTGS1 | GENE_SYMBOL |
Prostaglandin G/H synthase 1 | UNIPROT |
ENSG00000095303 | Gene Symbol |
PTGS1 | Ensembl Id |
DRUGGABLE GENOME |
Prostaglandin G/H synthase 1 | Gene Name |
P23219 | UniProt ID |
ENZYME |