5894 |
RAF-1 PROTO-ONCOGENE, SERINE/THREONINE KINASE |
RAF1 |
CMD1NN |
CRAF |
NS5 |
Raf-1 |
c-Raf |
164760 |
9829 |
ENSG00000132155 |
OTTHUMG00000129789 |
P04049 |
RAF1_HUMAN |
RAF |
Proto-oncogene c-RAF |
RAF proto-oncogene serine/threonine-protein kinase |
RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAF- 1) (C-RAF) (CRAF). [SOURCE:UNIPROT/SWISSPROT;ACC:P04049] |
PA34183 |
T23673 |
4767 |
Target Main Class | Enzymes |
Target Subclass | 2.7.11.1 |
Human Readable Name | DRUGGABLE GENOME |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.1 |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Human Readable Name | KINASE |
Interpro Type | Domain |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Acc | IPR001245 |
Uniprot Status | Swiss-Prot |
Gene Biotype | PROTEIN_CODING |
KINASE |
SERINE THREONINE KINASE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase RAF inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase RAF inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase RAF inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase RAF inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | RAF serine/threonine protein kinase inhibitor |
Direct Interaction | yes |
n/a |
Novel drug target | Established target |
Trial Name | CHIR-265 |
inhibitor (inhibitory) |
Trial Name | Nexavar |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase RAF inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase RAF inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase RAF inhibitor |
Direct Interaction | yes |
RAF1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000132155 | Ensembl Gene Id |
RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAF- 1) (C-RAF) (CRAF). [SOURCE:UNIPROT/SWISSPROT;ACC:P04049] | Description |
RAF1 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
P04049 | Uniprot Accession |
RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE | Uniprot Protein Name |
5894 | Entrez Gene Id |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Human Readable Name | KINASE |
Human Readable Name | DRUGGABLE GENOME |
KINASE, DRUGGABLE GENOME |
RAF1 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.1 |
5894 | Entrez Gene Id |
P04049 | Uniprot Accession |
RAF1_HUMAN | Uniprot Id |
Target Main Class | Enzymes |
Target Subclass | 2.7.11.1 |
PA34183 | PharmGKB ID |
5894 | Entrez Gene ID |
4767 | CIViC Gene ID |
ENSG00000132155 | Gene Symbol |
RAF1 | Ensembl Id |
DRUGGABLE GENOME |
5894 | Entrez Gene Id |
RAF1 | MyCancerGenome Gene Symbol |
RAF | MyCancerGenome Reported Gene Name |
RAF-1 | Gene Symbol |
C-RAF | Gene Symbol |
RAF | GENE_SYMBOL |
RAF1 | GENE_SYMBOL |
RAF proto-oncogene serine/threonine-protein kinase | UNIPROT |
5894 | OncoKB Entrez Id |
NS5 | OncoKB Gene Synonym |
c-Raf | OncoKB Gene Synonym |
RAF | GO Gene Synonym |
SERINE THREONINE KINASE |
RAF1 | Gene Symbol |
CLINICALLY ACTIONABLE |
5894 | Gene ID |
CRAF | dGene Synonym |
NS5 | dGene Synonym |
KINASE, SERINE THREONINE KINASE |
c-RAF | TTD Gene Abbreviation |
T23673 | TTD Target ID |
RAF proto-oncogene serine/threonine-protein kinase | Gene Name |
P04049 | UniProt ID |
KINASE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |