DGIdb - RXRB Gene Record

RXRB 6257 Druggable Genome

Alternate Names:

6257
RETINOID X RECEPTOR BETA
RXRB
DAUDI6
H-2RIIBP
NR2B2
RCoR-1
180246
10478
ENSG00000204231
OTTHUMG00000031298
ENSG00000112472
RETINOIC ACID RECEPTOR RXR-BETA (RETINOID X RECEPTOR BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:P28702]
P28702
RXRB_HUMAN
RETINOIC ACID RECEPTOR RXR-BETA
ENSG00000206289
ENSG00000227322
ENSG00000235712
ENSG00000228333
Nuclear receptor subfamily 2 group B member 2
ENSG00000204231; ENSG00000206289; ENSG00000228333; ENSG00000235712; ENSG00000231321; ENSG00000227322
ENSG00000231321
T60077
RXR-beta
RXRbeta

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Interpro Acc	IPR000536
Human Readable Name	NUCLEAR HORMONE RECEPTOR
Target Class	Receptors
Target Subclass	Nuclear receptor
Initial Gene Query	NR2B2
Counted Citations from 1950-2000	271
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME

Publications:

Nagpal et al., 2000, Recent developments in receptor-selective retinoids., Curr. Pharm. Des.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Schrage et al., 2006, Macrophages and neurons are targets of retinoic acid signaling after spinal cord contusion injury., Eur. J. Neurosci.
Redfern, 2004, Enhancing enhancers: new complexities in the retinoid regulation of gene expression., Biochem. J.
Stafslien et al., 2007, Analysis of ligand-dependent recruitment of coactivator peptides to RXRbeta in a time-resolved fluorescence resonance energy transfer assay., Mol. Cell. Endocrinol.
Hoegberg et al., 2005, Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms., Chem. Biol. Interact.
Nagasawa et al., 2005, Effect of retinoic acid on murine preosteoblastic MC3T3-E1 cells., J. Nutr. Sci. Vitaminol.
Yen et al., 2005, The selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced breast carcinoma., Mol. Cancer Ther.
Lalloyer et al., 2006, The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia., Arterioscler. Thromb. Vasc. Biol.
Yen et al., 2006, A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours., Br. J. Cancer
Rigas et al., 2005, Emerging role of rexinoids in non-small cell lung cancer: focus on bexarotene., Oncologist
Rizvi et al., 2001, Placebo-controlled trial of bexarotene, a retinoid x receptor agonist, as maintenance therapy for patients treated with chemotherapy for advanced non-small-cell lung cancer., Clin Lung Cancer
Farol et al., 2004, Bexarotene: a clinical review., Expert Rev Anticancer Ther
Tooker et al., 2007, Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification., Cancer Res.
Lowe et al., Bexarotene., Am J Clin Dermatol
Tsai et al., 2008, A phase I study of bexarotene, a retinoic X receptor agonist, in non-M3 acute myeloid leukemia., Clin. Cancer Res.
Cheng et al., 2008, Alitretinoin: a comprehensive review., Expert Opin Investig Drugs
Brtko, 2007, Role of retinoids and their cognate nuclear receptors in breast cancer chemoprevention., Cent. Eur. J. Public Health
Garnock-Jones et al., 2009, Alitretinoin: in severe chronic hand eczema., Drugs
Germain et al., 2006, International Union of Pharmacology. LXIII. Retinoid X receptors., Pharmacol. Rev.
Bergheim et al., 2005, Role of retinoic acid receptors in squamous-cell carcinoma in human esophagus., J Carcinog
Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.
Piérard GE et al., 2009, Spotlight on adapalene., Expert Opin Drug Metab Toxicol
Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.
Ghyselinck NB et al., 2019, Retinoic acid signaling pathways., Development

BEXAROTENE RXRB

Interaction Score: 11.45

Interaction Types & Directionality:

activator (activating)

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid X receptor agonist

Direct Interaction yes

Notes

PMIDs:
15897247 17008586 16495926 15632250 14700480 15056048 17483357 11702369 17016423 17139284 18765556

Sources:
TALC TdgClinicalTrial ChemblInteractions TEND
ALITRETINOIN RXRB

Interaction Score: 8.59

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
18321241 17491551 16420438 19678713 17132853 16277658 16109390

Sources:
ChemblInteractions TEND TTD
ADAPALENE RXRB

Interaction Score: 7.85

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10651997 17016423 17139284 19929446 9204085 31273085

Sources:
TdgClinicalTrial TEND
TAZAROTENE RXRB

Interaction Score: 4.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name tazarotene,Tazorac

PMIDs:
10828316 17016423 17139284

Sources:
TdgClinicalTrial TEND
ETRETINATE RXRB

Interaction Score: 2.94

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
17016423 17139284

Sources:
ChemblInteractions
IRX-4204 RXRB

Interaction Score: 2.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid X receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRETINOIN RXRB

Interaction Score: 1.66

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name tretinoin microsponge,Retin-A

PMIDs:
16420438 15379735 17184907 16109390 16392701

Sources:
TdgClinicalTrial TEND
ACITRETIN RXRB

Interaction Score: 1.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor agonist

PMIDs:
17016423 17139284

Sources:
ChemblInteractions
MOFAROTENE RXRB

Interaction Score: 1.14

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor modulator

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000204231
- Version: 101_38
Alternate Names:

RXRB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000112472
- Version: 26-July-2011
Alternate Names:

ENSG00000112472 Ensembl Gene Id

RETINOIC ACID RECEPTOR RXR-BETA (RETINOID X RECEPTOR BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:P28702] Description

RXRB Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
BaderLabGenes: RXRB
- Version: February-2014
Alternate Names:

6257 Entrez Gene ID

Gene Info:

Initial Gene Query NR2B2

Counted Citations from 1950-2000 271

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
HopkinsGroom: P28702
- Version: 11-September-2012
Alternate Names:

ENSG00000228333 Ensembl Gene Id

RXRB_HUMAN Uniprot Id

ENSG00000204231 Ensembl Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P28702
- Version: January-2014
Alternate Names:

RXRB Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Publications:
TEND: P28702
- Version: 01-August-2011
Alternate Names:

RXRB Gene Symbol

ENSG00000204231; ENSG00000206289; ENSG00000228333; ENSG00000235712; ENSG00000231321; ENSG00000227322 Ensembl Gene Id

RXRB_HUMAN Uniprot Id

Gene Info:

Target Subclass Nuclear receptor

Target Main Class Receptors

Publications:
TALC: RXRB
- Version: 12-May-2016
Alternate Names:

RXRB Gene Symbol

Gene Info:

Publications:
ChemblInteractions: NR2B2
- Version: chembl_23
Alternate Names:

NR2B2 GENE_SYMBOL

RXRB GENE_SYMBOL

Retinoic acid receptor RXR-beta UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000204231
- Version: 31-May-2017
Alternate Names:

ENSG00000204231 Gene Symbol

RXRB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: RXRB
- Version: 01-February-2022
Alternate Names:

NR2B2 GO Gene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
dGene: RXRB
- Version: 27-Jun-2013
Alternate Names:

6257 Gene ID

DAUDI6 dGene Synonym

H-2RIIBP dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
TTD: Retinoic acid receptor RXR-beta
- Version: 2020.06.01
Alternate Names:

RXRB TTD Gene Abbreviation

T60077 TTD Target ID

Gene Info:

Publications:
Pharos: RXRB
- Version: 01-February-2022
Alternate Names:

Retinoic acid receptor RXR-beta Gene Name

P28702 UniProt ID

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:

Mechanism of Interaction	Retinoid X receptor agonist
Direct Interaction	yes
Notes

Mechanism of Interaction	Retinoid receptor agonist
Direct Interaction	yes

Novel drug target	Established target
Trial Name	tazarotene,Tazorac

Direct Interaction	yes
Mechanism of Interaction	Retinoid receptor modulator

ENSG00000112472	Ensembl Gene Id
RETINOIC ACID RECEPTOR RXR-BETA (RETINOID X RECEPTOR BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:P28702]	Description
RXRB	Display Id

RXRB	Gene Symbol
ENSG00000204231; ENSG00000206289; ENSG00000228333; ENSG00000235712; ENSG00000231321; ENSG00000227322	Ensembl Gene Id
RXRB_HUMAN	Uniprot Id

NR2B2	GENE_SYMBOL
RXRB	GENE_SYMBOL
Retinoic acid receptor RXR-beta	UNIPROT

activator (activating)
agonist (activating)

RXRB Gene Record

RXRB 6257 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: activator (activating) agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid X receptor agonist Direct Interaction yes Notes

PMIDs: 15897247 17008586 16495926 15632250 14700480 15056048 17483357 11702369 17016423 17139284 18765556

Sources: TALC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes

PMIDs: 18321241 17491551 16420438 19678713 17132853 16277658 16109390

Sources: ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10651997 17016423 17139284 19929446 9204085 31273085

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name tazarotene,Tazorac

PMIDs: 10828316 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes

PMIDs: 17016423 17139284

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid X receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name tretinoin microsponge,Retin-A

PMIDs: 16420438 15379735 17184907 16109390 16392701

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Retinoid receptor agonist

PMIDs: 17016423 17139284

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Retinoid receptor modulator

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000204231

Alternate Names: RXRB Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000112472

Alternate Names: ENSG00000112472 Ensembl Gene Id RETINOIC ACID RECEPTOR RXR-BETA (RETINOID X RECEPTOR BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:P28702] Description RXRB Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

BaderLabGenes: RXRB

Alternate Names: 6257 Entrez Gene ID

Gene Info: Initial Gene Query NR2B2 Counted Citations from 1950-2000 271

Gene Categories: NUCLEAR HORMONE RECEPTOR

Publications:

HopkinsGroom: P28702

Alternate Names: ENSG00000228333 Ensembl Gene Id RXRB_HUMAN Uniprot Id ENSG00000204231 Ensembl Gene Id

Gene Info: Uniprot Evidence 1: Evidence at protein level Uniprot Status Swiss-Prot Human Readable Name DRUGGABLE GENOME

Gene Categories: NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P28702

Alternate Names: RXRB Gene Symbol

Gene Info: Target Class Receptors Target Subclass Nuclear receptor

Publications:

TEND: P28702

Alternate Names: RXRB Gene Symbol ENSG00000204231; ENSG00000206289; ENSG00000228333; ENSG00000235712; ENSG00000231321; ENSG00000227322 Ensembl Gene Id RXRB_HUMAN Uniprot Id

Gene Info: Target Subclass Nuclear receptor Target Main Class Receptors

Publications:

TALC: RXRB

Alternate Names: RXRB Gene Symbol

Gene Info:

Publications:

ChemblInteractions: NR2B2

Alternate Names: NR2B2 GENE_SYMBOL RXRB GENE_SYMBOL Retinoic acid receptor RXR-beta UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000204231

Alternate Names: ENSG00000204231 Gene Symbol RXRB Ensembl Id

Gene Info:

Interaction Types & Directionality:

activator (activating)

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid X receptor agonist

Direct Interaction yes

Notes

PMIDs:
15897247 17008586 16495926 15632250 14700480 15056048 17483357 11702369 17016423 17139284 18765556

Sources:
TALC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
18321241 17491551 16420438 19678713 17132853 16277658 16109390

Sources:
ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10651997 17016423 17139284 19929446 9204085 31273085

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name tazarotene,Tazorac

PMIDs:
10828316 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
17016423 17139284

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid X receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name tretinoin microsponge,Retin-A

PMIDs:
16420438 15379735 17184907 16109390 16392701

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor agonist

PMIDs:
17016423 17139284

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor modulator

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

RXRB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000112472 Ensembl Gene Id

RETINOIC ACID RECEPTOR RXR-BETA (RETINOID X RECEPTOR BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:P28702] Description

RXRB Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

6257 Entrez Gene ID

Gene Info:

Initial Gene Query NR2B2

Counted Citations from 1950-2000 271

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Alternate Names:

ENSG00000228333 Ensembl Gene Id

RXRB_HUMAN Uniprot Id

ENSG00000204231 Ensembl Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Alternate Names:

RXRB Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Alternate Names:

RXRB Gene Symbol

ENSG00000204231; ENSG00000206289; ENSG00000228333; ENSG00000235712; ENSG00000231321; ENSG00000227322 Ensembl Gene Id

RXRB_HUMAN Uniprot Id

Gene Info:

Target Subclass Nuclear receptor

Target Main Class Receptors

Alternate Names:

RXRB Gene Symbol

Alternate Names:

NR2B2 GENE_SYMBOL

RXRB GENE_SYMBOL

Retinoic acid receptor RXR-beta UNIPROT

Alternate Names:

ENSG00000204231 Gene Symbol

RXRB Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

NR2B2 GO Gene Synonym

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Alternate Names:

6257 Gene ID

DAUDI6 dGene Synonym

H-2RIIBP dGene Synonym

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Alternate Names:

RXRB TTD Gene Abbreviation

T60077 TTD Target ID

Alternate Names:

Retinoic acid receptor RXR-beta Gene Name

P28702 UniProt ID

Gene Categories:

NUCLEAR HORMONE RECEPTOR