S1PR1 Gene Record

  • OZANIMOD   S1PR1

    Interaction Score: 15.46

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name RPC1063
    Novel drug target Established target

    PMIDs:
    28398597 31492652 29125718


    Sources:
    TdgClinicalTrial TTD

  • FINGOLIMOD   S1PR1

    Interaction Score: 12.37

    Interaction Types & Directionality:
    agonist (activating)
    modulator

    Interaction Info:
    Trial Name fingolimod, FTY 720,Gilenia, Gilenya
    Novel drug target Established target

    PMIDs:
    22149256


    Sources:
    TdgClinicalTrial TEND TTD

  • PONESIMOD   S1PR1

    Interaction Score: 9.27

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name ponesimod
    Novel drug target Established target
    Mechanism of Interaction Sphingosine 1-phosphate receptor Edg-1 agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • KRP203   S1PR1

    Interaction Score: 6.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Sphingosine 1-phosphate receptor Edg-1 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • (S)-FTY720P   S1PR1

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19430484


    Sources:
    DTC

  • SIPONIMOD   S1PR1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Sphingosine 1-phosphate receptor Edg-1 agonist
    Direct Interaction yes

    PMIDs:
    517042 24900670 29138536


    Sources:
    ChemblInteractions TTD

  • BMS-986104   S1PR1

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ETRASIMOD   S1PR1

    Interaction Score: 3.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • GSK-2018682   S1PR1

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SONEPCIZUMAB   S1PR1

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ASP-4058   S1PR1

    Interaction Score: 1.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • AMISELIMOD HYDROCHLORIDE   S1PR1

    Interaction Score: 1.24

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Sphingosine 1-phosphate receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • FINGOLIMOD HYDROCHLORIDE   S1PR1

    Interaction Score: 0.62

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Sphingosine 1-phosphate receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL586135   S1PR1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL579318   S1PR1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL171699   S1PR1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1362503   S1PR1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PINAFIDE   S1PR1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ISOVELLERAL   S1PR1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 9,10-PHENANTHRENEQUINONE   S1PR1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000170989

    • Version: 101_38

    Alternate Names:
    S1PR1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P21453

    • Version: 01-August-2011

    Alternate Names:
    S1PR1 Gene Symbol
    P21453 Uniprot Accession
    S1PR1_HUMAN Uniprot Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass Rhodopsin
    Transmembrane Helix Count 7

    Publications:

  • RussLampel: ENSG00000170989

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000170989 Ensembl Gene Id
    SPHINGOSINE 1-PHOSPHATE RECEPTOR EDG-1 (SPHINGOSINE 1-PHOSPHATE RECEPTOR 1) (S1P1). [SOURCE:UNIPROT/SWISSPROT;ACC:P21453] Description
    EDG1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P21453

    • Version: January-2014

    Alternate Names:
    S1PR1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • HopkinsGroom: P21453

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000170989 Ensembl Gene Id
    S1PR1_HUMAN Uniprot Id
    S1PR1 Uniprot Gene Name

    Gene Info:
    Interpro Type Family
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • DTC: S1PR1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Mullershausen F et al., 2009, Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors., Nat Chem Biol

  • HingoraniCasas: ENSG00000170989

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000170989 Gene Symbol
    S1PR1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: CHEDG1

    • Version: chembl_23

    Alternate Names:
    EDG1 GENE_SYMBOL
    S1PR1 GENE_SYMBOL
    Sphingosine 1-phosphate receptor 1 UNIPROT

    Gene Info:

    Publications:

  • GO: S1PR1

    • Version: 01-February-2022

    Alternate Names:
    CHEDG1 GO Gene Synonym
    EDG1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • dGene: S1PR1

    • Version: 27-Jun-2013

    Alternate Names:
    1901 Gene ID
    CD363 dGene Synonym
    CHEDG1 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Sphingosine-1-phosphate receptor 1

    • Version: 2020.06.01

    Alternate Names:
    S1PR1 TTD Gene Abbreviation
    T13852 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: S1PR1

    • Version: 01-February-2022

    Alternate Names:
    Sphingosine 1-phosphate receptor 1 Gene Name
    P21453 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications: