DGIdb - SELP Gene Record

SELP 6403 Druggable Genome

Alternate Names:

6403
SELECTIN P
SELP
CD62
CD62P
GMP140
GRMP
LECAM3
PADGEM
PSEL
173610
10721
ENSG00000174175
OTTHUMG00000034685
P16109
GMRP
GMP-140
CD_antigen=CD62P
Platelet activation dependent granule-external membrane protein
Leukocyte-endothelial cell adhesion molecule 3
Granule membrane protein 140
CD62 antigen-like family member P
P-selectin
T10965

Gene Info:

Target Class	Receptors
Target Subclass	Receptors
Target Subclass	Selectin
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood

CRIZANLIZUMAB SELP

Interaction Score: 17.67

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name SelG1

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
RIVIPANSEL SELP

Interaction Score: 11.78

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name GMI-1070

Novel drug target Novel Target

Direct Interaction yes

PMIDs:
20508165

Sources:
TdgClinicalTrial ChemblInteractions TTD
RG-1512 SELP

Interaction Score: 8.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction P-selectin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
PSI-697 SELP

Interaction Score: 8.83

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TORAPSEL SELP

Interaction Score: 8.83

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name YSPSL, TS-1

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
BIMOSIAMOSE SELP

Interaction Score: 5.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Selectin inhibitor

Direct Interaction yes

Trial Name bimosiamose, TBC 1269

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
INCLACUMAB SELP

Interaction Score: 4.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction P-selectin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000174175
- Version: 101_38
Alternate Names:

SELP Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P16109
- Version: January-2014
Alternate Names:

SELP Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass Selectin

Publications:
TTD: P-selectin
- Version: 2020.06.01
Alternate Names:

SELP TTD Gene Abbreviation

T10965 TTD Target ID

Gene Info:

Publications:

Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood
HingoraniCasas: ENSG00000174175
- Version: 31-May-2017
Alternate Names:

ENSG00000174175 Gene Symbol

SELP Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: GMRP
- Version: chembl_23
Alternate Names:

GRMP GENE_SYMBOL

SELP GENE_SYMBOL

P-selectin UNIPROT

Gene Info:

Publications:
GO: SELP
- Version: 01-February-2022
Alternate Names:

GMRP GO Gene Synonym

GRMP GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Trial Name	GMI-1070
Novel drug target	Novel Target
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	P-selectin inhibitor

Mechanism of Interaction	Selectin inhibitor
Direct Interaction	yes
Trial Name	bimosiamose, TBC 1269

antibody (inhibitory)
inhibitor (inhibitory)

antagonist (inhibitory)
inhibitor (inhibitory)

GRMP	GENE_SYMBOL
SELP	GENE_SYMBOL
P-selectin	UNIPROT

SELP Gene Record

SELP 6403 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CRIZANLIZUMAB SELP

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name SelG1 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial TTD

RIVIPANSEL SELP

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name GMI-1070 Novel drug target Novel Target Direct Interaction yes

PMIDs: 20508165

Sources: TdgClinicalTrial ChemblInteractions TTD

RG-1512 SELP

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction P-selectin inhibitor

PMIDs: None found

Sources: ChemblInteractions

PSI-697 SELP

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TORAPSEL SELP

Interaction Types & Directionality: n/a

Interaction Info: Trial Name YSPSL, TS-1 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

BIMOSIAMOSE SELP

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Selectin inhibitor Direct Interaction yes Trial Name bimosiamose, TBC 1269

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

INCLACUMAB SELP

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction P-selectin inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000174175

Alternate Names: SELP Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P16109

Alternate Names: SELP Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptors Target Subclass Selectin

Publications:

TTD: P-selectin

Alternate Names: SELP TTD Gene Abbreviation T10965 TTD Target ID

Gene Info:

Publications: Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood

HingoraniCasas: ENSG00000174175

Alternate Names: ENSG00000174175 Gene Symbol SELP Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: GMRP

Alternate Names: GRMP GENE_SYMBOL SELP GENE_SYMBOL P-selectin UNIPROT

Gene Info:

Publications:

GO: SELP

Alternate Names: GMRP GO Gene Synonym GRMP GO Gene Synonym

Gene Info:

Gene Categories: EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name SelG1

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name GMI-1070

Novel drug target Novel Target

Direct Interaction yes

PMIDs:
20508165

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction P-selectin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name YSPSL, TS-1

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Selectin inhibitor

Direct Interaction yes

Trial Name bimosiamose, TBC 1269

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction P-selectin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

SELP Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SELP Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass Selectin

Alternate Names:

SELP TTD Gene Abbreviation

T10965 TTD Target ID

Publications:

Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood

Alternate Names:

ENSG00000174175 Gene Symbol

SELP Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GRMP GENE_SYMBOL

SELP GENE_SYMBOL

P-selectin UNIPROT

Alternate Names:

GMRP GO Gene Synonym

GRMP GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE