DGIdb - SLC12A1 Gene Record

SLC12A1 6557 Druggable Genome

Alternate Names:

6557
SOLUTE CARRIER FAMILY 12 MEMBER 1
SLC12A1
BSC1
NKCC2
600839
10910
ENSG00000074803
OTTHUMG00000131495
BUMETANIDE-SENSITIVE SODIUM-(POTASSIUM)-CHLORIDE COTRANSPORTER 2
KIDNEY-SPECIFIC NA-K-CL SYMPORTER
Q13621
S12A1_HUMAN
SOLUTE CARRIER FAMILY 12, MEMBER 1 (BUMETANIDE-SENSITIVE SODIUM- (POTASSIUM)-CHLORIDE COTRANSPORTER 2) (KIDNEY-SPECIFIC NA-K-CL SYMPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13621]
PA320
T93878

Gene Info:

Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR004841
Interpro Name	Amino acid permease domain
Interpro Short Name	AA-permease_dom
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Target Class	Transporters
Target Subclass	TC:2.A.30.1.2
Transmembrane Helix Count	11
Target Subclass	SLC12
Target Subclass	SLC
Target Subclass	APC
Target Main Class	Transporters
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

TRANSPORTER
DRUGGABLE GENOME

Publications:

Fortuño et al., 1999, Torasemide inhibits angiotensin II-induced vasoconstriction and intracellular calcium increase in the aorta of spontaneously hypertensive rats., Hypertension
Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Károlyi et al., 1998, The molecular genetic approach to "Bartter's syndrome"., J. Mol. Med.
Long et al., 2009, Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release., J. Biol. Chem.
Thakker, 1998, The role of renal chloride channel mutations in kidney stone disease and nephrocalcinosis., Curr. Opin. Nephrol. Hypertens.
Thakker, 1999, Chloride channels in renal disease., Adv. Nephrol. Necker Hosp.
Gamba, 2009, The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs., Am. J. Physiol. Renal Physiol.
Davies et al., 1975, Diuretics: mechanism of action and clinical application., Drugs
Brater, 2000, Pharmacology of diuretics., Am. J. Med. Sci.
Limmer F et al., 2015, Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration., FEBS J
Giménez I, 2006, Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters., Curr Opin Nephrol Hypertens
Li et al., 2007, Function and regulation of epithelial sodium transporters in the kidney of a salt-sensitive hypertensive rat model., J. Hypertens.
Hasannejad et al., 2004, Interactions of human organic anion transporters with diuretics., J. Pharmacol. Exp. Ther.
Smith, 2010, Thiazide diuretics., N. Engl. J. Med.
Mannuzzu et al., 1993, Estimate of the number of urea transport sites in erythrocyte ghosts using a hydrophobic mercurial., J. Membr. Biol.
Tabern et al., 1970, The quantitative measurement of tubular chlormerodrin binding as an index of renal function: a study of 400 cases., Can Med Assoc J

CHLORMERODRIN SLC12A1

Interaction Score: 14.27

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
8391582 5455277 17016423 17139284

Sources:
TdgClinicalTrial TEND
METHYCLOTHIAZIDE SLC12A1

Interaction Score: 9.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD
HYDROFLUMETHIAZIDE SLC12A1

Interaction Score: 9.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD
TRICHLORMETHIAZIDE SLC12A1

Interaction Score: 5.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17414671 14610216 11752352 20187262

Sources:
TdgClinicalTrial TEND TTD
CHLORTHALIDONE SLC12A1

Interaction Score: 5.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352 19474192

Sources:
TdgClinicalTrial TEND TTD
ETHACRYNATE SODIUM SLC12A1

Interaction Score: 4.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
FUROSEMIDE SLC12A1

Interaction Score: 4.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

PMIDs:
1092541 10653443 11752352 17460608 26183401 16914965

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
BUMETANIDE SLC12A1

Interaction Score: 3.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
9587066 19141616 9690036 11752352 10561751

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
METOLAZONE SLC12A1

Interaction Score: 3.17

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
TORSEMIDE SLC12A1

Interaction Score: 3.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
10406837 17460608 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
BENDROFLUMETHIAZIDE SLC12A1

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ALDOSTERONE SLC12A1

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ETHACRYNIC ACID SLC12A1

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000074803
- Version: 101_38
Alternate Names:

SLC12A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q13621
- Version: 11-September-2012
Alternate Names:

6557 Entrez Gene Id

S12A1_HUMAN Uniprot Id

ENSG00000074803 Ensembl Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR004841

Interpro Name Amino acid permease domain

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q13621
- Version: January-2014
Alternate Names:

SLC12A1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.30.1.2

Publications:

RussLampel: ENSG00000074803

Version: 26-July-2011

Alternate Names:

SOLUTE CARRIER FAMILY 12, MEMBER 1 (BUMETANIDE-SENSITIVE SODIUM- (POTASSIUM)-CHLORIDE COTRANSPORTER 2) (KIDNEY-SPECIFIC NA-K-CL SYMPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13621] Description

ENSG00000074803 Ensembl Gene Id

SLC12A1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: Q13621
- Version: 01-August-2011
Alternate Names:

S12A1_HUMAN Uniprot Id

ENSG00000074803 Ensembl Gene Id

Q13621 Uniprot Accession

Gene Info:

Transmembrane Helix Count 11

Target Subclass SLC12

Target Subclass SLC

Publications:
PharmGKB: SLC12A1
- Version: 18-August-2020
Alternate Names:

PA320 PharmGKB ID

Gene Info:

Publications:

Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics
HingoraniCasas: ENSG00000074803
- Version: 31-May-2017
Alternate Names:

ENSG00000074803 Gene Symbol

SLC12A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: NKCC2
- Version: chembl_23
Alternate Names:

NKCC2 GENE_SYMBOL

SLC12A1 GENE_SYMBOL

Solute carrier family 12 member 1 UNIPROT

Gene Info:

Publications:
TTD: Solute carrier family 12 member 1
- Version: 2020.06.01
Alternate Names:

SLC12A1 TTD Gene Abbreviation

T93878 TTD Target ID

Gene Info:

Publications:
Pharos: SLC12A1
- Version: 01-February-2022
Alternate Names:

Solute carrier family 12 member 1 Gene Name

Q13621 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:

Direct Interaction	yes
Mechanism of Interaction	Sodium-(potassium)-chloride cotransporter 2 inhibitor

Novel drug target	Established target
Trial Name	-
Mechanism of Interaction	Sodium-(potassium)-chloride cotransporter 2 inhibitor

6557	Entrez Gene Id
S12A1_HUMAN	Uniprot Id
ENSG00000074803	Ensembl Gene Id

SOLUTE CARRIER FAMILY 12, MEMBER 1 (BUMETANIDE-SENSITIVE SODIUM- (POTASSIUM)-CHLORIDE COTRANSPORTER 2) (KIDNEY-SPECIFIC NA-K-CL SYMPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13621]	Description
ENSG00000074803	Ensembl Gene Id
SLC12A1	Display Id

NKCC2	GENE_SYMBOL
SLC12A1	GENE_SYMBOL
Solute carrier family 12 member 1	UNIPROT

SLC12A1 Gene Record

SLC12A1 6557 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inducer (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 8391582 5455277 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17414671 14610216 11752352 20187262

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 11752352 19474192

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

PMIDs: 1092541 10653443 11752352 17460608 26183401 16914965

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor Direct Interaction yes Trial Name -

PMIDs: 9587066 19141616 9690036 11752352 10561751

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor Direct Interaction yes Trial Name -

PMIDs: 10406837 17460608 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000074803

Alternate Names: SLC12A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: Q13621

Alternate Names: 6557 Entrez Gene Id S12A1_HUMAN Uniprot Id ENSG00000074803 Ensembl Gene Id

Gene Info: Uniprot Evidence 1: Evidence at protein level Interpro Acc IPR004841 Interpro Name Amino acid permease domain

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: Q13621

Alternate Names: SLC12A1 Gene Symbol

Gene Info: Target Class Transporters Target Subclass TC:2.A.30.1.2

Publications:

RussLampel: ENSG00000074803

Alternate Names: SOLUTE CARRIER FAMILY 12, MEMBER 1 (BUMETANIDE-SENSITIVE SODIUM- (POTASSIUM)-CHLORIDE COTRANSPORTER 2) (KIDNEY-SPECIFIC NA-K-CL SYMPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13621] Description ENSG00000074803 Ensembl Gene Id SLC12A1 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: Q13621

Alternate Names: S12A1_HUMAN Uniprot Id ENSG00000074803 Ensembl Gene Id Q13621 Uniprot Accession

Gene Info: Transmembrane Helix Count 11 Target Subclass SLC12 Target Subclass SLC

Publications:

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
8391582 5455277 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17414671 14610216 11752352 20187262

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352 19474192

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

PMIDs:
1092541 10653443 11752352 17460608 26183401 16914965

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
9587066 19141616 9690036 11752352 10561751

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
10406837 17460608 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

SLC12A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

6557 Entrez Gene Id

S12A1_HUMAN Uniprot Id

ENSG00000074803 Ensembl Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR004841

Interpro Name Amino acid permease domain

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SLC12A1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.30.1.2

Alternate Names:

SOLUTE CARRIER FAMILY 12, MEMBER 1 (BUMETANIDE-SENSITIVE SODIUM- (POTASSIUM)-CHLORIDE COTRANSPORTER 2) (KIDNEY-SPECIFIC NA-K-CL SYMPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13621] Description

ENSG00000074803 Ensembl Gene Id

SLC12A1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

S12A1_HUMAN Uniprot Id

ENSG00000074803 Ensembl Gene Id

Q13621 Uniprot Accession

Gene Info:

Transmembrane Helix Count 11

Target Subclass SLC12

Target Subclass SLC

Alternate Names:

PA320 PharmGKB ID

Publications:

Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics

Alternate Names:

ENSG00000074803 Gene Symbol

SLC12A1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

NKCC2 GENE_SYMBOL

SLC12A1 GENE_SYMBOL

Solute carrier family 12 member 1 UNIPROT

Alternate Names:

SLC12A1 TTD Gene Abbreviation

T93878 TTD Target ID

Alternate Names:

Solute carrier family 12 member 1 Gene Name

Q13621 UniProt ID

Gene Categories:

TRANSPORTER