DGIdb - SSTR3 Gene Record

SSTR3 6753 Druggable Genome

Alternate Names:

6753
SOMATOSTATIN RECEPTOR 3
SSTR3
SS-3-R
SS3-R
SS3R
SSR-28
182453
11332
ENSG00000278195
OTTHUMG00000150537
P32745
SOMATOSTATIN RECEPTOR TYPE 3
ENSG00000183473
SSR3_HUMAN
SOMATOSTATIN RECEPTOR TYPE 3 (SS3R) (SSR-28). [SOURCE:UNIPROT/SWISSPROT;ACC:P32745]
T13644
-

Gene Info:

Uniprot Status	Swiss-Prot
Interpro Name	GPCR, rhodopsin-like, 7TM
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Acc	IPR000276
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

KINASE
G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Erchegyi J et al., 2011, N-imidazolebenzyl-histidine substitution in somatostatin and in its octapeptide analogue modulates receptor selectivity and function., J Med Chem
Rai U et al., 2015, Therapeutic uses of somatostatin and its analogues: Current view and potential applications., Pharmacol Ther
Zatelli et al., 2007, Pasireotide, a multiple somatostatin receptor subtypes ligand, reduces cell viability in non-functioning pituitary adenomas by inhibiting vascular endothelial growth factor secretion., Endocr. Relat. Cancer
Bruns et al., 2002, SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile., Eur. J. Endocrinol.

SOMATOSTATIN SSTR3

Interaction Score: 26.5

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
21806016 25956467

Sources:
DTC
PASIREOTIDE SSTR3

Interaction Score: 8.83

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name pasireotide, SOM230

Novel drug target Novel Target

PMIDs:
17395978 11980628

Sources:
TdgClinicalTrial TTD
CHEMBL452157 SSTR3

Interaction Score: 5.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21806016

Sources:
DTC TTD
VAPREOTIDE SSTR3

Interaction Score: 2.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor 3 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PASIREOTIDE DIASPARTATE SSTR3

Interaction Score: 2.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Somatostatin receptor 3 agonist

PMIDs:
None found

Sources:
ChemblInteractions
PASIREOTIDE PAMOATE SSTR3

Interaction Score: 2.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor 3 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OCTREOTIDE ACETATE SSTR3

Interaction Score: 1.77

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000278195
- Version: 101_38
Alternate Names:

SSTR3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P32745
- Version: 11-September-2012
Alternate Names:

ENSG00000183473 Ensembl Gene Id

P32745 Uniprot Accession

SSR3_HUMAN Uniprot Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Name GPCR, rhodopsin-like, 7TM

Interpro Short Name 7TM_GPCR_Rhodpsn

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P32745
- Version: January-2014
Alternate Names:

SSTR3 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
RussLampel: ENSG00000183473
- Version: 26-July-2011
Alternate Names:

SSTR3 Display Id

SOMATOSTATIN RECEPTOR TYPE 3 (SS3R) (SSR-28). [SOURCE:UNIPROT/SWISSPROT;ACC:P32745] Description

ENSG00000183473 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
DTC: SSTR3
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Erchegyi J et al., 2011, N-imidazolebenzyl-histidine substitution in somatostatin and in its octapeptide analogue modulates receptor selectivity and function., J Med Chem
HingoraniCasas: ENSG00000183473
- Version: 31-May-2017
Alternate Names:

ENSG00000183473 Gene Symbol

SSTR3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: SSTR3
- Version: chembl_23
Alternate Names:

SSTR3 GENE_SYMBOL

Somatostatin receptor type 3 UNIPROT

SSR-28 UNIPROT

Gene Info:

Publications:
dGene: SSTR3
- Version: 27-Jun-2013
Alternate Names:

6753 Gene ID

- dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Somatostatin receptor type 3
- Version: 2020.06.01
Alternate Names:

SSTR3 TTD Gene Abbreviation

T13644 TTD Target ID

Gene Info:

Publications:
Pharos: SSTR3
- Version: 01-February-2022
Alternate Names:

Somatostatin receptor type 3 Gene Name

P32745 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: SSTR3
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Mechanism of Interaction	Somatostatin receptor 3 agonist
Direct Interaction	yes

Mechanism of Interaction	Somatostatin receptor agonist
Direct Interaction	yes

ENSG00000183473	Ensembl Gene Id
P32745	Uniprot Accession
SSR3_HUMAN	Uniprot Id

SSTR3	Display Id
SOMATOSTATIN RECEPTOR TYPE 3 (SS3R) (SSR-28). [SOURCE:UNIPROT/SWISSPROT;ACC:P32745]	Description
ENSG00000183473	Ensembl Gene Id

SSTR3	GENE_SYMBOL
Somatostatin receptor type 3	UNIPROT
SSR-28	UNIPROT

Trial Name	pasireotide, SOM230
Novel drug target	Novel Target

SSTR3 Gene Record

SSTR3 6753 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

SOMATOSTATIN SSTR3

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 21806016 25956467

Sources: DTC

PASIREOTIDE SSTR3

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name pasireotide, SOM230 Novel drug target Novel Target

PMIDs: 17395978 11980628

Sources: TdgClinicalTrial TTD

CHEMBL452157 SSTR3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21806016

Sources: DTC TTD

VAPREOTIDE SSTR3

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Somatostatin receptor 3 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

PASIREOTIDE DIASPARTATE SSTR3

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Somatostatin receptor 3 agonist

PMIDs: None found

Sources: ChemblInteractions

PASIREOTIDE PAMOATE SSTR3

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Somatostatin receptor 3 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

OCTREOTIDE ACETATE SSTR3

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Somatostatin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000278195

Alternate Names: SSTR3 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P32745

Alternate Names: ENSG00000183473 Ensembl Gene Id P32745 Uniprot Accession SSR3_HUMAN Uniprot Id

Gene Info: Uniprot Status Swiss-Prot Interpro Name GPCR, rhodopsin-like, 7TM Interpro Short Name 7TM_GPCR_Rhodpsn

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P32745

Alternate Names: SSTR3 Gene Symbol

Gene Info: Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin

Publications:

RussLampel: ENSG00000183473

Alternate Names: SSTR3 Display Id SOMATOSTATIN RECEPTOR TYPE 3 (SS3R) (SSR-28). [SOURCE:UNIPROT/SWISSPROT;ACC:P32745] Description ENSG00000183473 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

DTC: SSTR3

Alternate Names:

Gene Info:

Publications: Erchegyi J et al., 2011, N-imidazolebenzyl-histidine substitution in somatostatin and in its octapeptide analogue modulates receptor selectivity and function., J Med Chem

HingoraniCasas: ENSG00000183473

Alternate Names: ENSG00000183473 Gene Symbol SSTR3 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: SSTR3

Alternate Names: SSTR3 GENE_SYMBOL Somatostatin receptor type 3 UNIPROT SSR-28 UNIPROT

Gene Info:

Publications:

dGene: SSTR3

Alternate Names: 6753 Gene ID - dGene Synonym

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

TTD: Somatostatin receptor type 3

Alternate Names: SSTR3 TTD Gene Abbreviation T13644 TTD Target ID

Gene Info:

Interaction Types & Directionality:

agonist (activating)

PMIDs:
21806016 25956467

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name pasireotide, SOM230

Novel drug target Novel Target

PMIDs:
17395978 11980628

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
21806016

Sources:
DTC TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor 3 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Somatostatin receptor 3 agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor 3 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

SSTR3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000183473 Ensembl Gene Id

P32745 Uniprot Accession

SSR3_HUMAN Uniprot Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Name GPCR, rhodopsin-like, 7TM

Interpro Short Name 7TM_GPCR_Rhodpsn

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

SSTR3 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

SSTR3 Display Id

SOMATOSTATIN RECEPTOR TYPE 3 (SS3R) (SSR-28). [SOURCE:UNIPROT/SWISSPROT;ACC:P32745] Description

ENSG00000183473 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

Erchegyi J et al., 2011, N-imidazolebenzyl-histidine substitution in somatostatin and in its octapeptide analogue modulates receptor selectivity and function., J Med Chem

Alternate Names:

ENSG00000183473 Gene Symbol

SSTR3 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SSTR3 GENE_SYMBOL

Somatostatin receptor type 3 UNIPROT

SSR-28 UNIPROT

Alternate Names:

6753 Gene ID

- dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

SSTR3 TTD Gene Abbreviation

T13644 TTD Target ID

Alternate Names:

Somatostatin receptor type 3 Gene Name

P32745 UniProt ID

Gene Categories:

KINASE

Gene Categories:

G PROTEIN COUPLED RECEPTOR