DGIdb - TNFSF11 Gene Record

TNFSF11 8600 Druggable Genome

Alternate Names:

8600
TNF SUPERFAMILY MEMBER 11
TNFSF11
CD254
ODF
OPGL
OPTB2
RANKL
TNLG6B
TRANCE
hRANKL2
sOdf
602642
11926
ENSG00000120659
OTTHUMG00000016807
TNF11_HUMAN
O14788
OSTEOPROTEGERIN LIGAND
OSTEOCLAST DIFFERENTIATION FACTOR
TNF-RELATED ACTIVATION-INDUCED CYTOKINE
TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 11
Tumor necrosis factor ligand superfamily member 11, membrane form
Tumor necrosis factor ligand superfamily member 11, soluble form
Receptor activator of nuclear factor kappa-B ligand
CD_antigen=CD254
PA36619
T21334

Gene Info:

Target Class	Miscellaneous
Target Subclass	Ligand
Target Subclass	Cytokine
Target Class	Ligand
Target Main Class	Other
Transmembrane Helix Count	1
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

KINASE
DRUGGABLE GENOME

Publications:

Lipton et al., 2008, RANKL inhibition in the treatment of bone metastases., Curr Opin Support Palliat Care
Westenfeld et al., 2006, Anti-RANKL therapy--implications for the bone-vascular-axis in CKD? Denosumab in post-menopausal women with low bone mineral density., Nephrol. Dial. Transplant.
Melchert et al., 2007, The thalidomide saga., Int. J. Biochem. Cell Biol.
Akobeng et al., 2009, Thalidomide and thalidomide analogues for maintenance of remission in Crohn's disease., Cochrane Database Syst Rev

DENOSUMAB TNFSF11

Interaction Score: 69.56

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name Denosumab

Novel drug target Established target

PMIDs:
18685421 16702197

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions TEND TTD
LENALIDOMIDE TNFSF11

Interaction Score: 3.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Revlimid

PMIDs:
17369076 19370685

Sources:
TdgClinicalTrial
ANASTROZOLE TNFSF11

Interaction Score: 1.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LETROZOLE TNFSF11

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000120659
- Version: 101_38
Alternate Names:

TNFSF11 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: O14788
- Version: 01-August-2011
Alternate Names:

O14788 Uniprot Accession

8600 Entrez Gene Id

TNFSF11 Gene Symbol

Gene Info:

Target Main Class Other

Transmembrane Helix Count 1

Target Subclass Ligand

Publications:
TdgClinicalTrial: O14788
- Version: January-2014
Alternate Names:

TNFSF11 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Ligand

Target Subclass Cytokine

Publications:
MyCancerGenome: RANKL
- Version: 20-Jun-2017
Alternate Names:

8600 Entrez Gene Id

RANKL MyCancerGenome Gene Symbol

RANKL MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000120659
- Version: 31-May-2017
Alternate Names:

ENSG00000120659 Gene Symbol

TNFSF11 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: RANKL
- Version: 12-May-2016
Alternate Names:

RANKL Gene Symbol

Gene Info:

Publications:
ChemblInteractions: OPGL
- Version: chembl_23
Alternate Names:

RANKL GENE_SYMBOL

TRANCE GENE_SYMBOL

TNFSF11 GENE_SYMBOL

Gene Info:

Publications:
PharmGKB: TNFSF11
- Version: 18-August-2020
Alternate Names:

PA36619 PharmGKB ID

Gene Info:

Publications:
TTD: Osteoclast differentiation factor
- Version: 2020.06.01
Alternate Names:

ODF TTD Gene Abbreviation

T21334 TTD Target ID

Gene Info:

Publications:
Pharos: TNFSF11
- Version: 01-February-2022
Alternate Names:

Tumor necrosis factor ligand superfamily member 11 Gene Name

O14788 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
ClearityFoundationClinicalTrial: TNFSF11
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

8600	Entrez Gene Id
RANKL	MyCancerGenome Gene Symbol
RANKL	MyCancerGenome Reported Gene Name

Tumor necrosis factor ligand superfamily member 11	Gene Name
O14788	UniProt ID

antibody (inhibitory)
inhibitor (inhibitory)

Notes
Trial Name	Denosumab
Novel drug target	Established target

Novel drug target	Established target
Trial Name	Revlimid

RANKL	GENE_SYMBOL
TRANCE	GENE_SYMBOL
TNFSF11	GENE_SYMBOL

TNFSF11 Gene Record

TNFSF11 8600 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

DENOSUMAB TNFSF11

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Notes Trial Name Denosumab Novel drug target Established target

PMIDs: 18685421 16702197

Sources: TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions TEND TTD

LENALIDOMIDE TNFSF11

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Revlimid

PMIDs: 17369076 19370685

Sources: TdgClinicalTrial

ANASTROZOLE TNFSF11

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

LETROZOLE TNFSF11

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000120659

Alternate Names: TNFSF11 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: O14788

Alternate Names: O14788 Uniprot Accession 8600 Entrez Gene Id TNFSF11 Gene Symbol

Gene Info: Target Main Class Other Transmembrane Helix Count 1 Target Subclass Ligand

Publications:

TdgClinicalTrial: O14788

Alternate Names: TNFSF11 Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Ligand Target Subclass Cytokine

Publications:

MyCancerGenome: RANKL

Alternate Names: 8600 Entrez Gene Id RANKL MyCancerGenome Gene Symbol RANKL MyCancerGenome Reported Gene Name

Gene Info:

Publications:

HingoraniCasas: ENSG00000120659

Alternate Names: ENSG00000120659 Gene Symbol TNFSF11 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TALC: RANKL

Alternate Names: RANKL Gene Symbol

Gene Info:

Publications:

ChemblInteractions: OPGL

Alternate Names: RANKL GENE_SYMBOL TRANCE GENE_SYMBOL TNFSF11 GENE_SYMBOL

Gene Info:

Publications:

PharmGKB: TNFSF11

Alternate Names: PA36619 PharmGKB ID

Gene Info:

Publications:

TTD: Osteoclast differentiation factor

Alternate Names: ODF TTD Gene Abbreviation T21334 TTD Target ID

Gene Info:

Publications:

Pharos: TNFSF11

Alternate Names: Tumor necrosis factor ligand superfamily member 11 Gene Name O14788 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

ClearityFoundationClinicalTrial: TNFSF11

Alternate Names:

Gene Info:

Publications:

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name Denosumab

Novel drug target Established target

PMIDs:
18685421 16702197

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Revlimid

PMIDs:
17369076 19370685

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

TNFSF11 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

O14788 Uniprot Accession

8600 Entrez Gene Id

TNFSF11 Gene Symbol

Gene Info:

Target Main Class Other

Transmembrane Helix Count 1

Target Subclass Ligand

Alternate Names:

TNFSF11 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Ligand

Target Subclass Cytokine

Alternate Names:

8600 Entrez Gene Id

RANKL MyCancerGenome Gene Symbol

RANKL MyCancerGenome Reported Gene Name

Alternate Names:

ENSG00000120659 Gene Symbol

TNFSF11 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

RANKL Gene Symbol

Alternate Names:

RANKL GENE_SYMBOL

TRANCE GENE_SYMBOL

TNFSF11 GENE_SYMBOL

Alternate Names:

PA36619 PharmGKB ID

Alternate Names:

ODF TTD Gene Abbreviation

T21334 TTD Target ID

Alternate Names:

Tumor necrosis factor ligand superfamily member 11 Gene Name

O14788 UniProt ID

Gene Categories:

KINASE