DGIdb - TPO Gene Record

TPO 7173 Druggable Genome

Alternate Names:

7173
THYROID PEROXIDASE
TPO
MSA
TDH2A
TPX
606765
12015
ENSG00000115705
OTTHUMG00000090271
P07202
THYROID PEROXIDASE PRECURSOR (EC 1.11.1.8) (TPO). [SOURCE:UNIPROT/SWISSPROT;ACC:P07202]
PERT_HUMAN
T51120

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Type	Family
Uniprot Status	Swiss-Prot
Interpro Name	Haem peroxidase, animal
Interpro Acc	IPR002007
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Haem_peroxidase_animal
Target Main Class	Enzymes
Target Subclass	1.11
Transmembrane Helix Count	1
Target Class	Enzymes
Target Subclass	EC:1.11.1.8
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUGGABLE GENOME
ENZYME

Publications:

Nakashima et al., 1979, Rapid conversion of carbimazole to methimazole in serum; evidence for an enzymatic mechanism., Clin. Endocrinol. (Oxf)
Taurog, 1976, The mechanism of action of the thioureylene antithyroid drugs., Endocrinology
Humar et al., 2008, Thionamides inhibit the transcription factor nuclear factor-kappaB by suppression of Rac1 and inhibitor of kappaB kinase alpha., J. Pharmacol. Exp. Ther.
Guilhem et al., 2006, Differential evolution of thyroid peroxidase and thyrotropin receptor antibodies in Graves' disease: thyroid peroxidase antibody activity reverts to pretreatment level after carbimazole withdrawal., Thyroid
Orgiazzi et al., 1994, [Theoretical aspects of the treatment with antithyroid drugs]., Ann. Endocrinol. (Paris)
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Perrild et al., 1994, Diagnosis and treatment of thyrotoxicosis in childhood. A European questionnaire study., Eur. J. Endocrinol.
Magnusson et al., 1984, Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase., J. Biol. Chem.
Ferreira et al., 2003, Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole., Eur. J. Biochem.
Chiovato et al., 1991, The microsomal/peroxidase antigen: modulation of its expression in thyroid cells., Autoimmunity
Manzon et al., 2001, Variable effects of goitrogens in inducing precocious metamorphosis in sea lampreys (Petromyzon marinus)., J. Exp. Zool.
Sugawara et al., 1999, Methimazole and propylthiouracil increase cellular thyroid peroxidase activity and thyroid peroxidase mRNA in cultured porcine thyroid follicles., Thyroid
Magnusson et al., 1992, Effect of serum thyrotropin levels on the concentration of messenger RNA for thyroid peroxidase in the rat., Acta Endocrinol.
Burch HB et al., 2018, ANNIVERSARY REVIEW: Antithyroid drug therapy: 70 years later, Eur J Endocrinol
Schmutzler et al., 2007, The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase., Endocrinology
Taurog et al., 1989, A reexamination of the proposed inactivation of thyroid peroxidase in the rat thyroid by propylthiouracil., Endocrinology

CARBIMAZOLE TPO

Interaction Score: 37.78

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
476986 1278093 18055877 17042691 7528484 11752352 7952157 6706930

Sources:
TdgClinicalTrial TEND TTD
METHIMAZOLE TPO

Interaction Score: 12.59

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

Interaction Info:

Mechanism of Interaction Thyroid peroxidase inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12755690 1663395 11241400 10365684 11752352 1320313 30320502

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
PROPYLTHIOURACIL TPO

Interaction Score: 12.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Thyroid peroxidase inhibitor

PMIDs:
12755690 11241400 17379648 10365684 11752352 2656250

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Ensembl: ENSG00000115705
- Version: 101_38
Alternate Names:

TPO Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P07202
- Version: January-2014
Alternate Names:

TPO Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.11.1.8

Publications:
TEND: P07202
- Version: 01-August-2011
Alternate Names:

ENSG00000115705 Ensembl Gene Id

P07202 Uniprot Accession

PERT_HUMAN Uniprot Id

Gene Info:

Target Main Class Enzymes

Target Subclass 1.11

Transmembrane Helix Count 1

Publications:
HopkinsGroom: P07202
- Version: 11-September-2012
Alternate Names:

thyroid peroxidase Uniprot Protein Name

P07202 Uniprot Accession

7173 Entrez Gene Id

Gene Info:

Interpro Type Family

Uniprot Status Swiss-Prot

Interpro Name Haem peroxidase, animal

Gene Categories:

DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000115705
- Version: 26-July-2011
Alternate Names:

TPO Display Id

ENSG00000115705 Ensembl Gene Id

THYROID PEROXIDASE PRECURSOR (EC 1.11.1.8) (TPO). [SOURCE:UNIPROT/SWISSPROT;ACC:P07202] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
NCI: TPO
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

del Senno et al., 1993, Retinoic acid-induced decrease of DNA synthesis and peroxidase mRNA levels in human thyroid cells expressing retinoic acid receptor alpha mRNA., Life Sci.
HingoraniCasas: ENSG00000115705
- Version: 31-May-2017
Alternate Names:

ENSG00000115705 Gene Symbol

TPO Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: TPO
- Version: chembl_23
Alternate Names:

TPO GENE_SYMBOL

Thyroid peroxidase UNIPROT

TPO UNIPROT

Gene Info:

Publications:
TTD: Thyroid peroxidase
- Version: 2020.06.01
Alternate Names:

TPO TTD Gene Abbreviation

T51120 TTD Target ID

Gene Info:

Publications:
Pharos: TPO
- Version: 01-February-2022
Alternate Names:

Thyroid peroxidase Gene Name

P07202 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: TPO
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE

Publications:

Mechanism of Interaction	Thyroid peroxidase inhibitor
Direct Interaction	yes
Trial Name	-

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Thyroid peroxidase inhibitor

ENSG00000115705	Ensembl Gene Id
P07202	Uniprot Accession
PERT_HUMAN	Uniprot Id

thyroid peroxidase	Uniprot Protein Name
P07202	Uniprot Accession
7173	Entrez Gene Id

TPO	Display Id
ENSG00000115705	Ensembl Gene Id
THYROID PEROXIDASE PRECURSOR (EC 1.11.1.8) (TPO). [SOURCE:UNIPROT/SWISSPROT;ACC:P07202]	Description

inhibitor (inhibitory)
substrate

TPO Gene Record

TPO 7173 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CARBIMAZOLE TPO

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 476986 1278093 18055877 17042691 7528484 11752352 7952157 6706930

Sources: TdgClinicalTrial TEND TTD

METHIMAZOLE TPO

Interaction Types & Directionality: inhibitor (inhibitory) substrate

Interaction Info: Mechanism of Interaction Thyroid peroxidase inhibitor Direct Interaction yes Trial Name -

PMIDs: 12755690 1663395 11241400 10365684 11752352 1320313 30320502

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

PROPYLTHIOURACIL TPO

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Thyroid peroxidase inhibitor

PMIDs: 12755690 11241400 17379648 10365684 11752352 2656250

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Ensembl: ENSG00000115705

Alternate Names: TPO Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P07202

Alternate Names: TPO Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:1.11.1.8

Publications:

TEND: P07202

Alternate Names: ENSG00000115705 Ensembl Gene Id P07202 Uniprot Accession PERT_HUMAN Uniprot Id

Gene Info: Target Main Class Enzymes Target Subclass 1.11 Transmembrane Helix Count 1

Publications:

HopkinsGroom: P07202

Alternate Names: thyroid peroxidase Uniprot Protein Name P07202 Uniprot Accession 7173 Entrez Gene Id

Gene Info: Interpro Type Family Uniprot Status Swiss-Prot Interpro Name Haem peroxidase, animal

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000115705

Alternate Names: TPO Display Id ENSG00000115705 Ensembl Gene Id THYROID PEROXIDASE PRECURSOR (EC 1.11.1.8) (TPO). [SOURCE:UNIPROT/SWISSPROT;ACC:P07202] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

NCI: TPO

Alternate Names:

Gene Info:

Publications: del Senno et al., 1993, Retinoic acid-induced decrease of DNA synthesis and peroxidase mRNA levels in human thyroid cells expressing retinoic acid receptor alpha mRNA., Life Sci.

HingoraniCasas: ENSG00000115705

Alternate Names: ENSG00000115705 Gene Symbol TPO Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: TPO

Alternate Names: TPO GENE_SYMBOL Thyroid peroxidase UNIPROT TPO UNIPROT

Gene Info:

Publications:

TTD: Thyroid peroxidase

Alternate Names: TPO TTD Gene Abbreviation T51120 TTD Target ID

Gene Info:

Publications:

Pharos: TPO

Alternate Names: Thyroid peroxidase Gene Name P07202 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

GO: TPO

Alternate Names:

Gene Info:

Gene Categories: CELL SURFACE

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
476986 1278093 18055877 17042691 7528484 11752352 7952157 6706930

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

Interaction Info:

Mechanism of Interaction Thyroid peroxidase inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12755690 1663395 11241400 10365684 11752352 1320313 30320502

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Thyroid peroxidase inhibitor

PMIDs:
12755690 11241400 17379648 10365684 11752352 2656250

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Alternate Names:

TPO Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TPO Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.11.1.8

Alternate Names:

ENSG00000115705 Ensembl Gene Id

P07202 Uniprot Accession

PERT_HUMAN Uniprot Id

Gene Info:

Target Main Class Enzymes

Target Subclass 1.11

Transmembrane Helix Count 1

Alternate Names:

thyroid peroxidase Uniprot Protein Name

P07202 Uniprot Accession

7173 Entrez Gene Id

Gene Info:

Interpro Type Family

Uniprot Status Swiss-Prot

Interpro Name Haem peroxidase, animal

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TPO Display Id

ENSG00000115705 Ensembl Gene Id

THYROID PEROXIDASE PRECURSOR (EC 1.11.1.8) (TPO). [SOURCE:UNIPROT/SWISSPROT;ACC:P07202] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

del Senno et al., 1993, Retinoic acid-induced decrease of DNA synthesis and peroxidase mRNA levels in human thyroid cells expressing retinoic acid receptor alpha mRNA., Life Sci.

Alternate Names:

ENSG00000115705 Gene Symbol

TPO Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TPO GENE_SYMBOL

Thyroid peroxidase UNIPROT

TPO UNIPROT

Alternate Names:

TPO TTD Gene Abbreviation

T51120 TTD Target ID

Alternate Names:

Thyroid peroxidase Gene Name

P07202 UniProt ID

Gene Categories:

ENZYME

Gene Categories:

CELL SURFACE