7298 |
THYMIDYLATE SYNTHETASE |
TYMS |
HST422 |
TMS |
TS |
188350 |
12441 |
ENSG00000176890 |
OTTHUMG00000131473 |
Thymidylate synthase |
TSase |
PA359 |
TYSY_HUMAN |
P04818 |
5971 |
THYMIDYLATE SYNTHASE (EC 2.1.1.45) (TS) (TSASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P04818] |
T98397 |
Target Main Class | Enzymes |
Target Subclass | 2.1.1.45 |
Human Readable Name | DRUGGABLE GENOME |
Target Class | Enzymes |
Target Subclass | EC:2.1.1.45 |
Interpro Short Name | Thymidylate_synthase |
Interpro Name | Thymidylate synthase |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR000398 |
Interpro Type | Family |
Uniprot Evidence | 1: Evidence at protein level |
Gene Biotype | PROTEIN_CODING |
DRUG RESISTANCE |
DRUGGABLE GENOME |
ENZYME |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | raltitrexed, ZD-1694,Tomudex |
inhibitor (inhibitory) |
Trial Name | Alimta |
Novel drug target | Established target |
Trial Name | - |
n/a |
Trial Name | Modufolin |
Novel drug target | Established target |
n/a |
Trial Name | OSI-7904L |
Novel drug target | Established target |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | CPX-1 |
Mechanism of Interaction | Thymidylate synthase inhibitor |
inhibitor (inhibitory) |
Trial Name | UFT |
Novel drug target | Established target |
Trial Name | S-1, TS1 |
inhibitor (inhibitory) |
Mechanism of Interaction | Thymidylate synthase inhibitor |
Direct Interaction | yes |
other/unknown |
inhibitor (inhibitory) |
Mechanism of Interaction | Thymidylate synthase inhibitor |
Direct Interaction | yes |
n/a |
Trial Name | Fusilev |
Novel drug target | Established target |
TYMS | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000176890 | Ensembl Gene Id |
7298 | Entrez Gene Id |
P04818 | Uniprot Accession |
Interpro Short Name | Thymidylate_synthase |
Human Readable Name | DRUGGABLE GENOME |
Interpro Name | Thymidylate synthase |
DRUGGABLE GENOME |
ENSG00000176890 | Ensembl Gene Id |
TYMS | Display Id |
THYMIDYLATE SYNTHASE (EC 2.1.1.45) (TS) (TSASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P04818] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
TYMS | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.1.1.45 |
TYMS | Gene Symbol |
7298 | Entrez Gene Id |
ENSG00000176890 | Ensembl Gene Id |
Target Main Class | Enzymes |
Target Subclass | 2.1.1.45 |
PA359 | PharmGKB ID |
7298 | Entrez Gene ID |
5971 | CIViC Gene ID |
DRUG RESISTANCE |
ENSG00000176890 | Gene Symbol |
TYMS | Ensembl Id |
DRUGGABLE GENOME |
TS | GENE_SYMBOL |
TYMS | GENE_SYMBOL |
Thymidylate synthase | UNIPROT |
TYMS | Gene Symbol |
CLINICALLY ACTIONABLE |
TYMS | TTD Gene Abbreviation |
T98397 | TTD Target ID |
Thymidylate synthase | Gene Name |
P04818 | UniProt ID |
ENZYME |