DGIdb - ALISKIREN Drug Record

ALISKIREN chembl:CHEMBL1639 Approved

Alternate Names:

RASILEZ
SPP100
SPP-100
ALISKIREN
CGP-060536B
SPP 100
rxcui:325646
drugbank:09026
pubchem.compound:5493444
chembl:CHEMBL1639
chemidplus:173334-57-1

Drug Info:

Drug Class	antihypertensive agents
Year of Approval	2007
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent

(1 More Sources)

Publications:

Ménard et al., 2006, Conformational changes in prorenin during renin inhibition in vitro and in vivo., J. Hypertens.
Gradman et al., 2006, New drugs for hypertension: what do they offer?, Curr. Hypertens. Rep.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Azizi et al., 2006, Renin inhibition with aliskiren: where are we now, and where are we going?, J. Hypertens.
Wood et al., 2003, Structure-based design of aliskiren, a novel orally effective renin inhibitor., Biochem. Biophys. Res. Commun.
Nussberger et al., 2002, Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril., Hypertension
Wal P et al., 2011, Aliskiren: An orally active renin inhibitor., J Pharm Bioallied Sci

ALISKIREN REN

Interaction Score: 38.64

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Aliskiren

Novel drug target Established target

Trial Name aliskiren + amlodipine,Tekamlo

PMIDs:
16467656 16965731 11752352 16508564 12927775 11799102 21687346

Sources:
TdgClinicalTrial TEND TTD
ALISKIREN ABCB1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

TEND: ALISKIREN
- Version: 01-August-2011
Alternate Names:

ALISKIREN Primary Drug Name

Drug Info:

Year of Approval 2007

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: ALISKIREN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:
TTD: Aliskiren
- Version: 2020.06.01
Alternate Names:

D03SVX TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1639
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: aliskiren
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	Aliskiren
Novel drug target	Established target
Trial Name	aliskiren + amlodipine,Tekamlo

ALISKIREN Drug Record

ALISKIREN chembl:CHEMBL1639 Approved

Alternate Names:

Drug Info:

Publications:

ALISKIREN REN

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Aliskiren Novel drug target Established target Trial Name aliskiren + amlodipine,Tekamlo

PMIDs: 16467656 16965731 11752352 16508564 12927775 11799102 21687346

Sources: TdgClinicalTrial TEND TTD

ALISKIREN ABCB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

TEND: ALISKIREN

Alternate Names: ALISKIREN Primary Drug Name

Drug Info: Year of Approval 2007 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: ALISKIREN

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval approved

Publications:

TTD: Aliskiren

Alternate Names: D03SVX TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1639

Alternate Names:

Drug Info:

Publications:

PharmGKB: aliskiren

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Aliskiren

Novel drug target Established target

Trial Name aliskiren + amlodipine,Tekamlo

PMIDs:
16467656 16965731 11752352 16508564 12927775 11799102 21687346

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

ALISKIREN Primary Drug Name

Drug Info:

Year of Approval 2007

Drug Class antihypertensive agents

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D03SVX TTD Drug ID