DGIdb - ALSEROXYLON Drug Record

ALSEROXYLON chembl:CHEMBL1201454 Approved

Alternate Names:

ALSEROXYLON
RAUTENSIN
RAUWILOID
chemidplus:8001-95-4
RAU-TAB
EGALIN
rxcui:599
drugbank:00386
chembl:CHEMBL1201454

Drug Info:

Year of Approval	not approved by the fda
Drug Class	antipsychotic agents
Drug Class	antihypertensive agents
FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Antihypertensive Agents
Drug Indications	Antipsychotic Agents

(1 More Sources)

Publications:

FORD et al., 1958, Rauwolfia toxicity in the treatment of hypertension; comparative toxicity of reserpine and alseroxylon., Postgrad Med
SCHLAGEL et al., 1957, Rauwolfia hypotension. II. Action of the alseroxylon alkaloids and epinephrine on the carotid pressoreceptors., J Am Pharm Assoc Am Pharm Assoc
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

ALSEROXYLON SLC18A2

Interaction Score: 4.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
13505370 13438725 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD
ALSEROXYLON ADRA2B

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALSEROXYLON ADRA1B

Interaction Score: 0.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALSEROXYLON ADRA2C

Interaction Score: 0.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALSEROXYLON ADRA2A

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALSEROXYLON ADRA1A

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

TEND: ALSEROXYLON
- Version: 01-August-2011
Alternate Names:

ALSEROXYLON Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class antipsychotic agents

Year of Approval not approved by the fda

Publications:
TdgClinicalTrial: ALSEROXYLON
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antipsychotic Agents

Drug Indications Antihypertensive Agents

Drug Class small molecule

Publications:
TTD: Alseroxylon
- Version: 2020.06.01
Alternate Names:

D0I3IG TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201454
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1201454
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Adrenergic receptor alpha antagonist
Direct Interaction	yes

Trial Name	-
Novel drug target	Established target

ALSEROXYLON Drug Record

ALSEROXYLON chembl:CHEMBL1201454 Approved

Alternate Names:

Drug Info:

Publications:

ALSEROXYLON SLC18A2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 13505370 13438725 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND TTD

ALSEROXYLON ADRA2B

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ALSEROXYLON ADRA1B

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ALSEROXYLON ADRA2C

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ALSEROXYLON ADRA2A

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ALSEROXYLON ADRA1A

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

TEND: ALSEROXYLON

Alternate Names: ALSEROXYLON Primary Drug Name

Drug Info: Drug Class antihypertensive agents Drug Class antipsychotic agents Year of Approval not approved by the fda

Publications:

TdgClinicalTrial: ALSEROXYLON

Alternate Names:

Drug Info: Drug Indications Antipsychotic Agents Drug Indications Antihypertensive Agents Drug Class small molecule

Publications:

TTD: Alseroxylon

Alternate Names: D0I3IG TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201454

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1201454

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
13505370 13438725 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

ALSEROXYLON Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class antipsychotic agents

Year of Approval not approved by the fda

Drug Info:

Drug Indications Antipsychotic Agents

Drug Indications Antihypertensive Agents

Drug Class small molecule

Alternate Names:

D0I3IG TTD Drug ID