DGIdb - ADRA2B Gene Record

ADRA2B 151 Druggable Genome

Alternate Names:

151
ADRENOCEPTOR ALPHA 2B
ADRA2B
ADRA2L1
ADRA2RL1
ADRARL1
ALPHA2BAR
FAME2
alpha-2BAR
104260
282
ENSG00000274286
OTTHUMG00000188276
ENSG00000181210
ALPHA-2B ADRENERGIC RECEPTOR (ALPHA-2B ADRENOCEPTOR) (ALPHA-2B ADRENORECEPTOR) (SUBTYPE C2). [SOURCE:UNIPROT/SWISSPROT;ACC:P18089]
P18089
ADA2B_HUMAN
ENSG00000222040
ALPHA-2B ADRENERGIC RECEPTOR
Alpha-2B adrenoceptor
Alpha-2B adrenoreceptor
Alpha-2 adrenergic receptor subtype C2
PA36
Adrenergic receptor alpha-2B
T41580

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Transmembrane Helix Count	7
Target Subclass	Rhodopsin
Target Subclass	GPCR
Target Main Class	Receptors
Uniprot Status	Swiss-Prot
Interpro Short Name	7TM_GPCR_Rhodpsn
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Acc	IPR000276
Uniprot Evidence	2: Evidence at transcript level
Interpro Type	Family
Interpro Name	GPCR, rhodopsin-like, 7TM
Target Class	Receptors
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

CELL SURFACE
G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Millan MJ et al., 2000, S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine., J Pharmacol Exp Ther
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Nash, 1990, Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism., Clin Cardiol
Vizi et al., 2001, Evidence for presynaptic cannabinoid CB(1) receptor-mediated inhibition of noradrenaline release in the guinea pig lung., Eur. J. Pharmacol.
Gobbi et al., 1990, The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not mediated by the alpha 2B-adrenoceptor subtype., Naunyn Schmiedebergs Arch. Pharmacol.
Rudling et al., 2000, A comparison of agonist-specific coupling of cloned human alpha(2)-adrenoceptor subtypes., Br. J. Pharmacol.
Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Piletz et al., 1996, Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes., J. Pharmacol. Exp. Ther.
Bohmann et al., 1993, Methoxamine inhibits noradrenaline release through activation of alpha 1- and alpha 2-adrenoceptors in rat isolated kidney: involvement of purines and prostaglandins., Naunyn Schmiedebergs Arch. Pharmacol.
Trendelenburg et al., 2003, All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons., Naunyn Schmiedebergs Arch. Pharmacol.
Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
Ariëns EJ et al., 1983, Physiological and pharmacological aspects of adrenergic receptor classification., Biochem Pharmacol
Cleary et al., 2002, Investigation of neurotransmission in vas deferens from alpha(2A/D)-adrenoceptor knockout mice., Br. J. Pharmacol.
Gyires et al., 2000, Functional evidence that gastroprotection can be induced by activation of central alpha(2B)-adrenoceptor subtypes in the rat., Eur. J. Pharmacol.
Takada et al., 2002, Meperidine exerts agonist activity at the alpha(2B)-adrenoceptor subtype., Anesthesiology
Freitag et al., 1996, Adrenoceptor- and cholinoceptor-mediated mechanisms in the regulation of 5-hydroxytryptamine release from isolated tracheae of newborn rabbits., Br. J. Pharmacol.
Millan et al., 2000, Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states., Synapse
Alonso et al., 2007, Yohimbine prevents morphine-induced changes of glial fibrillary acidic protein in brainstem and alpha2-adrenoceptor gene expression in hippocampus., Neurosci. Lett.
Creagh et al., 2010, Alpha-2B adrenergic receptor mediated hemodynamic profile of etomidate., P R Health Sci J
Paris et al., 2003, Activation of alpha 2B-adrenoceptors mediates the cardiovascular effects of etomidate., Anesthesiology
Giovannoni et al., 2009, Alpha2-agonists as analgesic agents., Med Res Rev
Davis, 2010, Recent advances in the treatment of pain., F1000 Med Rep
Jeng et al., 1998, Methamphetamine modulates GABA-induced electrophysiological depression by alternating noradrenergic actions in cerebellar Purkinje neurons., Psychopharmacology (Berl.)
Sulzer et al., 2005, Mechanisms of neurotransmitter release by amphetamines: a review., Prog. Neurobiol.
Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.

YOHIMBINE ADRA2B

Interaction Score: 1.89

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12110610 10822066 12170055 8872361 10611634 17123717

Sources:
TdgClinicalTrial TEND PharmGKB
FENOLDOPAM ADRA2B

Interaction Score: 0.63

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17016423 17139284 7670737

Sources:
TEND
DROXIDOPA ADRA2B

Interaction Score: 0.63

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
18680204 18064417 21173850

Sources:
ChemblInteractions
LOFEXIDINE ADRA2B

Interaction Score: 0.63

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name lofexidine,BritLofex

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
TIZANIDINE ADRA2B

Interaction Score: 0.63

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name NVD-422, tizanidine oral spray

Novel drug target Established target

Trial Name tizanidine hydrochloride,Zanaflex

PMIDs:
8930173

Sources:
TdgClinicalTrial
BRIMONIDINE ADRA2B

Interaction Score: 0.56

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
8097565 14610637

Sources:
TEND PharmGKB
CLONIDINE ADRA2B

Interaction Score: 0.56

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs:
11082457

Sources:
TdgClinicalTrial ChemblInteractions PharmGKB
NOREPINEPHRINE ADRA2B

Interaction Score: 0.55

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1980236 11728431 1979424 11053214 18064417 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB
BRIMONIDINE TARTRATE ADRA2B

Interaction Score: 0.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MOXONIDINE ADRA2B

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TIZANIDINE HYDROCHLORIDE ADRA2B

Interaction Score: 0.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
APRACLONIDINE HYDROCHLORIDE ADRA2B

Interaction Score: 0.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METHYLDOPATE HYDROCHLORIDE ADRA2B

Interaction Score: 0.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FADOLMIDINE HYDROCHLORIDE ADRA2B

Interaction Score: 0.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DEXMEDETOMIDINE HYDROCHLORIDE ADRA2B

Interaction Score: 0.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

PMIDs:
None found

Sources:
ChemblInteractions
FIPAMEZOLE ADRA2B

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name fipamezole, JP-1730

PMIDs:
None found

Sources:
TdgClinicalTrial
CLONIDINE HYDROCHLORIDE ADRA2B

Interaction Score: 0.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DEBRISOQUIN ADRA2B

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
EPINEPHRINE ADRA2B

Interaction Score: 0.38

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name transdermal lidocaine/epinephrine patch,Lidosite

Novel drug target Established target

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
1980236 1979424 11053214 11728431 18064417 6134529

Sources:
TdgClinicalTrial ChemblInteractions PharmGKB
GUANFACINE HYDROCHLORIDE ADRA2B

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BETHANIDINE ADRA2B

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
GUANABENZ ACETATE ADRA2B

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

PMIDs:
None found

Sources:
ChemblInteractions
ETOMIDATE ADRA2B

Interaction Score: 0.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
20496522 14508322

Sources:
TdgClinicalTrial TEND
RAUWOLFIA SERPENTINA ADRA2B

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha antagonist

PMIDs:
None found

Sources:
ChemblInteractions
ESMIRTAZAPINE MALEATE ADRA2B

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEDETOMIDINE ADRA2B

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ALSEROXYLON ADRA2B

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NAPHAZOLINE HYDROCHLORIDE ADRA2B

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRAHYDROZOLINE HYDROCHLORIDE ADRA2B

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SENREBOTASE ADRA2B

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AGN-214868

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
OXYMETAZOLINE HYDROCHLORIDE ADRA2B

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPIVEFRIN HYDROCHLORIDE ADRA2B

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOLAZOLINE HYDROCHLORIDE ADRA2B

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPHENTERMINE SULFATE ADRA2B

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENTOLAMINE MESYLATE ADRA2B

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METHAMPHETAMINE ADRA2B

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name low dose intravenous methamphetamine

Novel drug target Established target

PMIDs:
9551769 15955613

Sources:
TdgClinicalTrial
PHENOXYBENZAMINE HYDROCHLORIDE ADRA2B

Interaction Score: 0.14

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LABETALOL HYDROCHLORIDE ADRA2B

Interaction Score: 0.14

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ASENAPINE ADRA2B

Interaction Score: 0.14

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

PMIDs:
18308814

Sources:
TdgClinicalTrial
HYDROXYAMPHETAMINE HYDROBROMIDE ADRA2B

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LEVONORDEFRIN ADRA2B

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NOREPINEPHRINE BITARTRATE ADRA2B

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ERGOLOID MESYLATES ADRA2B

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha antagonist

PMIDs:
None found

Sources:
ChemblInteractions
EPINEPHRINE BITARTRATE ADRA2B

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
DOPAMINE ADRA2B

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
MIRTAZAPINE ADRA2B

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METHYLDOPA ADRA2B

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ISOPROTERENOL ADRA2B

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
OLANZAPINE ADRA2B

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ALKS 3831

Trial Name OREX-003, olanzapine plus zonisamide SR

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
17848919

Sources:
TdgClinicalTrial

Ensembl: ENSG00000274286
- Version: 101_38
Alternate Names:

ADRA2B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P18089
- Version: 11-September-2012
Alternate Names:

ADA2B_HUMAN Uniprot Id

ALPHA-2B ADRENERGIC RECEPTOR Uniprot Protein Name

ADRA2B Uniprot Gene Name

Gene Info:

Uniprot Status Swiss-Prot

Interpro Short Name 7TM_GPCR_Rhodpsn

Human Readable Name G PROTEIN COUPLED RECEPTOR

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P18089
- Version: January-2014
Alternate Names:

ADRA2B Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:

RussLampel: ENSG00000181210

Version: 26-July-2011

Alternate Names:

ENSG00000181210 Ensembl Gene Id

ALPHA-2B ADRENERGIC RECEPTOR (ALPHA-2B ADRENOCEPTOR) (ALPHA-2B ADRENORECEPTOR) (SUBTYPE C2). [SOURCE:UNIPROT/SWISSPROT;ACC:P18089] Description

ADRA2B Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: P18089
- Version: 01-August-2011
Alternate Names:

ADA2B_HUMAN Uniprot Id

ENSG00000222040 Ensembl Gene Id

ADRA2B Gene Symbol

Gene Info:

Transmembrane Helix Count 7

Target Subclass Rhodopsin

Target Subclass GPCR

Publications:
HingoraniCasas: ENSG00000222040
- Version: 31-May-2017
Alternate Names:

ENSG00000222040 Gene Symbol

ADRA2B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ADRA2L1
- Version: chembl_23
Alternate Names:

ADRA2RL1 GENE_SYMBOL

ADRA2B GENE_SYMBOL

Alpha-2B adrenergic receptor UNIPROT

Gene Info:

Publications:
PharmGKB: ADRA2B
- Version: 18-August-2020
Alternate Names:

PA36 PharmGKB ID

Gene Info:

Publications:
GO: ADRA2B
- Version: 01-February-2022
Alternate Names:

ADRA2L1 GO Gene Synonym

ADRA2RL1 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, G PROTEIN COUPLED RECEPTOR

Publications:
dGene: ADRA2B
- Version: 27-Jun-2013
Alternate Names:

151 Gene ID

ADRA2L1 dGene Synonym

ADRA2RL1 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Adrenergic receptor alpha-2B
- Version: 2020.06.01
Alternate Names:

ADRA2B TTD Gene Abbreviation

T41580 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Adrenergic receptor agonist
Direct Interaction	yes

Trial Name	lofexidine,BritLofex
Novel drug target	Established target

Trial Name	NVD-422, tizanidine oral spray
Novel drug target	Established target
Trial Name	tizanidine hydrochloride,Zanaflex

Mechanism of Interaction	Adrenergic receptor alpha-2 agonist
Direct Interaction	yes
Trial Name	ARC-4558, 0.1% clonidine hycrochloride gel

Trial Name	transdermal lidocaine/epinephrine patch,Lidosite
Novel drug target	Established target
Mechanism of Interaction	Adrenergic receptor agonist

Direct Interaction	yes
Mechanism of Interaction	Adrenergic receptor alpha antagonist

Mechanism of Interaction	Adrenergic receptor alpha-2 antagonist
Direct Interaction	yes

Mechanism of Interaction	Adrenergic receptor alpha agonist
Direct Interaction	yes

Trial Name	low dose intravenous methamphetamine
Novel drug target	Established target

Mechanism of Interaction	Adrenergic receptor antagonist
Direct Interaction	yes

Trial Name	ALKS 3831
Trial Name	OREX-003, olanzapine plus zonisamide SR
Trial Name	Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

ADA2B_HUMAN	Uniprot Id
ALPHA-2B ADRENERGIC RECEPTOR	Uniprot Protein Name
ADRA2B	Uniprot Gene Name

ENSG00000181210	Ensembl Gene Id
ALPHA-2B ADRENERGIC RECEPTOR (ALPHA-2B ADRENOCEPTOR) (ALPHA-2B ADRENORECEPTOR) (SUBTYPE C2). [SOURCE:UNIPROT/SWISSPROT;ACC:P18089]	Description
ADRA2B	Display Id

ADRA2RL1	GENE_SYMBOL
ADRA2B	GENE_SYMBOL
Alpha-2B adrenergic receptor	UNIPROT

ADRA2B Gene Record

ADRA2B 151 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12110610 10822066 12170055 8872361 10611634 17123717

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 17016423 17139284 7670737

Sources: TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor agonist Direct Interaction yes

PMIDs: 18680204 18064417 21173850

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name lofexidine,BritLofex Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name NVD-422, tizanidine oral spray Novel drug target Established target Trial Name tizanidine hydrochloride,Zanaflex

PMIDs: 8930173

Sources: TdgClinicalTrial

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 8097565 14610637

Sources: TEND PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs: 11082457

Sources: TdgClinicalTrial ChemblInteractions PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1980236 11728431 1979424 11053214 18064417 17016423 17139284

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adrenergic receptor alpha-2 agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name fipamezole, JP-1730

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name transdermal lidocaine/epinephrine patch,Lidosite Novel drug target Established target Mechanism of Interaction Adrenergic receptor agonist

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12110610 10822066 12170055 8872361 10611634 17123717

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
17016423 17139284 7670737

Sources:
TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
18680204 18064417 21173850

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name lofexidine,BritLofex

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name NVD-422, tizanidine oral spray

Novel drug target Established target

Trial Name tizanidine hydrochloride,Zanaflex

PMIDs:
8930173

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

PMIDs:
8097565 14610637

Sources:
TEND PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs:
11082457

Sources:
TdgClinicalTrial ChemblInteractions PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1980236 11728431 1979424 11053214 18064417 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name fipamezole, JP-1730

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name transdermal lidocaine/epinephrine patch,Lidosite

Novel drug target Established target

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
1980236 1979424 11053214 11728431 18064417 6134529

Sources:
TdgClinicalTrial ChemblInteractions PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found