DGIdb - AT-406 Drug Record

AT-406 chembl:CHEMBL2158051 Antineoplastic

Alternate Names:

AT-406
DEBIO 1143
IAP INHIBITOR AT-406
DEBIO-1143

Drug Info:

(0 More Sources)

Publications:

Liu N et al., 2014, Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro., Am J Cancer Res
Cai et al., 2011, A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment., J. Med. Chem.

AT-406 BIRC2

Interaction Score: 19.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Notes

PMIDs:
25520882 21443232

Sources:
TALC DTC TTD
AT-406 BIRC3

Interaction Score: 11.59

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Notes

PMIDs:
25520882

Sources:
TALC TTD
AT-406 BIRC7

Interaction Score: 7.73

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
AT-406 XIAP

Interaction Score: 2.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Notes

PMIDs:
25520882

Sources:
TALC TTD

TTD: AT-406

Version: 2020.06.01

Alternate Names:

D03MXK TTD Drug ID

Drug Info:

Publications:

Liu N et al., 2014, Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro., Am J Cancer Res

DTC: AT-406
- Version: 02-September-2020
Alternate Names:

CHEMBL2158051 ChEMBL Drug ID

Drug Info:

Publications:

Cai et al., 2011, A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment., J. Med. Chem.
TALC: AT-406
- Version: 12-May-2016
Alternate Names:

AT-406 Primary Drug Name

AT-406 Drug Synonym

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL2158051
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

AT-406 Drug Record

AT-406 chembl:CHEMBL2158051 Antineoplastic

Alternate Names:

Drug Info:

Publications:

AT-406 BIRC2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Notes

PMIDs: 25520882 21443232

Sources: TALC DTC TTD

AT-406 BIRC3

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Notes

PMIDs: 25520882

Sources: TALC TTD

AT-406 BIRC7

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Notes

PMIDs: None found

Sources: TALC

AT-406 XIAP

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Notes

PMIDs: 25520882

Sources: TALC TTD

TTD: AT-406

Alternate Names: D03MXK TTD Drug ID

Drug Info:

Publications: Liu N et al., 2014, Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro., Am J Cancer Res

DTC: AT-406

Alternate Names: CHEMBL2158051 ChEMBL Drug ID

Drug Info:

Publications: Cai et al., 2011, A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment., J. Med. Chem.

TALC: AT-406

Alternate Names: AT-406 Primary Drug Name AT-406 Drug Synonym

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL2158051

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Notes

PMIDs:
25520882 21443232

Sources:
TALC DTC TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Notes

PMIDs:
25520882

Sources:
TALC TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Notes

PMIDs:
25520882

Sources:
TALC TTD

Alternate Names:

D03MXK TTD Drug ID

Publications:

Liu N et al., 2014, Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro., Am J Cancer Res

Alternate Names:

CHEMBL2158051 ChEMBL Drug ID

Publications:

Cai et al., 2011, A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment., J. Med. Chem.

Alternate Names:

AT-406 Primary Drug Name

AT-406 Drug Synonym