DGIdb - BIRC3 Gene Record

BIRC3 330 Druggable GenomeClinically Actionable

Alternate Names:

330
BACULOVIRAL IAP REPEAT CONTAINING 3
BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
601721
591
ENSG00000023445
OTTHUMG00000167324
IAP homolog C
Inhibitor of apoptosis protein 1
RING finger protein 49
RING-type E3 ubiquitin transferase BIRC3
TNFR2-TRAF-signaling complex protein 1
hIAP-1
Baculoviral IAP repeat-containing protein 3
Apoptosis inhibitor 2
Cellular inhibitor of apoptosis 2
Q13489
T35173
IAP-1

Gene Info:

Target Class	Miscellaneous
Target Subclass	Inhibitor of apoptosis
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

TUMOR SUPPRESSOR
KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Liu N et al., 2014, Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro., Am J Cancer Res
Sato S et al., 2008, Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs., Bioorg Med Chem Lett

AT-406 BIRC3

Interaction Score: 11.59

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Notes

PMIDs:
25520882

Sources:
TALC TTD
BIRINAPANT BIRC3

Interaction Score: 10.3

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction cIAP1/cIAP2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC ChemblInteractions
BESTATIN METHYL ESTER BIRC3

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18448338

Sources:
DTC
LCL-161 BIRC3

Interaction Score: 5.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC

Ensembl: ENSG00000023445
- Version: 101_38
Alternate Names:

BIRC3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q13489
- Version: January-2014
Alternate Names:

BIRC3 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Inhibitor of apoptosis

Publications:

TTD: Cellular inhibitor of apoptosis 2

Version: 2020.06.01

Alternate Names:

BIRC3 TTD Gene Abbreviation

T35173 TTD Target ID

Gene Info:

Publications:

Liu N et al., 2014, Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro., Am J Cancer Res

DTC: BIRC3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Sato S et al., 2008, Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs., Bioorg Med Chem Lett

TALC: C-IAP2
- Version: 12-May-2016
Alternate Names:

C-IAP2 Gene Symbol

Gene Info:

Publications:
HingoraniCasas: ENSG00000023445
- Version: 31-May-2017
Alternate Names:

ENSG00000023445 Gene Symbol

BIRC3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: API2
- Version: chembl_23
Alternate Names:

MIHC GENE_SYMBOL

RNF49 GENE_SYMBOL

BIRC3 GENE_SYMBOL

Gene Info:

Publications:
HumanProteinAtlas: BIRC3
- Version: 19.3
Alternate Names:

ENSG00000023445 Ensembl Gene ID

API2 Human Protein Atlas Gene Synonym

c-IAP2 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: BIRC3
- Version: 01-February-2022
Alternate Names:

API2 GO Gene Synonym

MIHC GO Gene Synonym

RNF49 GO Gene Synonym

Gene Info:

Gene Categories:

TUMOR SUPPRESSOR

Publications:
Tempus: BIRC3
- Version: 11-November-2018
Alternate Names:

BIRC3 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: BIRC3
- Version: 01-February-2022
Alternate Names:

Baculoviral IAP repeat-containing protein 3 Gene Name

Q13489 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
FoundationOneGenes: BIRC3
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: BIRC3
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Notes
Mechanism of Interaction	cIAP1/cIAP2 inhibitor
Direct Interaction	yes

ENSG00000023445	Ensembl Gene ID
API2	Human Protein Atlas Gene Synonym
c-IAP2	Human Protein Atlas Gene Synonym

Baculoviral IAP repeat-containing protein 3	Gene Name
Q13489	UniProt ID

antagonist (inhibitory)
inhibitor (inhibitory)

MIHC	GENE_SYMBOL
RNF49	GENE_SYMBOL
BIRC3	GENE_SYMBOL

BIRC3 Gene Record

BIRC3 330 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

AT-406 BIRC3

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Notes

PMIDs: 25520882

Sources: TALC TTD

BIRINAPANT BIRC3

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Notes Mechanism of Interaction cIAP1/cIAP2 inhibitor Direct Interaction yes

PMIDs: None found

Sources: TALC ChemblInteractions

BESTATIN METHYL ESTER BIRC3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18448338

Sources: DTC

LCL-161 BIRC3

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Notes

PMIDs: None found

Sources: TALC

Ensembl: ENSG00000023445

Alternate Names: BIRC3 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q13489

Alternate Names: BIRC3 Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Inhibitor of apoptosis

Publications:

TTD: Cellular inhibitor of apoptosis 2

Alternate Names: BIRC3 TTD Gene Abbreviation T35173 TTD Target ID

Gene Info:

Publications: Liu N et al., 2014, Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro., Am J Cancer Res

DTC: BIRC3

Alternate Names:

Gene Info:

Publications: Sato S et al., 2008, Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs., Bioorg Med Chem Lett

TALC: C-IAP2

Alternate Names: C-IAP2 Gene Symbol

Gene Info:

Publications:

HingoraniCasas: ENSG00000023445

Alternate Names: ENSG00000023445 Gene Symbol BIRC3 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: API2

Alternate Names: MIHC GENE_SYMBOL RNF49 GENE_SYMBOL BIRC3 GENE_SYMBOL

Gene Info:

Publications:

HumanProteinAtlas: BIRC3

Alternate Names: ENSG00000023445 Ensembl Gene ID API2 Human Protein Atlas Gene Synonym c-IAP2 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

GO: BIRC3

Alternate Names: API2 GO Gene Synonym MIHC GO Gene Synonym RNF49 GO Gene Synonym

Gene Info:

Gene Categories: TUMOR SUPPRESSOR

Publications:

Tempus: BIRC3

Alternate Names: BIRC3 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Pharos: BIRC3

Alternate Names: Baculoviral IAP repeat-containing protein 3 Gene Name Q13489 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

FoundationOneGenes: BIRC3

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Notes

PMIDs:
25520882

Sources:
TALC TTD

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction cIAP1/cIAP2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
18448338

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC

Alternate Names:

BIRC3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

BIRC3 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Inhibitor of apoptosis

Alternate Names:

BIRC3 TTD Gene Abbreviation

T35173 TTD Target ID

Publications:

Liu N et al., 2014, Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro., Am J Cancer Res

Publications:

Sato S et al., 2008, Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs., Bioorg Med Chem Lett

Alternate Names:

C-IAP2 Gene Symbol

Alternate Names:

ENSG00000023445 Gene Symbol

BIRC3 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MIHC GENE_SYMBOL

RNF49 GENE_SYMBOL

BIRC3 GENE_SYMBOL

Alternate Names:

ENSG00000023445 Ensembl Gene ID

API2 Human Protein Atlas Gene Synonym

c-IAP2 Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

API2 GO Gene Synonym

MIHC GO Gene Synonym

RNF49 GO Gene Synonym

Gene Categories:

TUMOR SUPPRESSOR

Alternate Names:

BIRC3 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

Baculoviral IAP repeat-containing protein 3 Gene Name

Q13489 UniProt ID

Gene Categories:

KINASE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE