DGIdb - AZD-8055 Drug Record

AZD-8055 chembl:CHEMBL1801204 Antineoplastic

Alternate Names:

AZ-12600000
AZD-8055
AZD8055
AZD 8055

Drug Info:

Notes	catalytic inhibitor
Notes	TORC1/2, catalytic inhibitor
Drug Class	Kinase Inhibitors

(1 More Sources)

Publications:

Singleton et al., 2015, Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC., Cancer Res.
Pike et al., 2013, Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014., Bioorg. Med. Chem. Lett.
Kiessling et al., 2015, Mutant HRAS as novel target for MEK and mTOR inhibitors., Oncotarget
Swick et al., 2017, Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC., Mol. Cancer Ther.
Holt et al., 2012, Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055)., Cancer Res.
Hayes et al., 2016, Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression., Cancer Cell
Weisberg et al., 2015, Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies., Leukemia
Andrade-Vieira et al., 2014, Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss., Oncotarget

AZD-8055 MAPKAP1

Interaction Score: 1.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
AZD-8055 DEPTOR

Interaction Score: 1.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
AZD-8055 MLST8

Interaction Score: 1.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
AZD-8055 AKT1S1

Interaction Score: 1.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
AZD-8055 RICTOR

Interaction Score: 1.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
AZD-8055 RPTOR

Interaction Score: 1.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
AZD-8055 FKBP1A

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23375793

Sources:
DTC
AZD-8055 STK11

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type breast cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
25436981

Sources:
JAX-CKB
AZD-8055 HRAS

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy AZD8055 + Binimetinib

Indication/Tumor Type lung squamous cell carcinoma

Response Type sensitive

PMIDs:
26544513

Sources:
JAX-CKB
AZD-8055 MTOR

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase mTOR inhibitor

PMIDs:
23375793

Sources:
DTC MyCancerGenome ChemblInteractions
AZD-8055 KRAS

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Approval Status Preclinical - Cell culture

Indication/Tumor Type pancreatic ductal adenocarcinoma

combination therapy AZD8055 + SCH772984

PMIDs:
26725216 22271687 24791855

Sources:
JAX-CKB
AZD-8055 FGFR1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy AZD4547 + AZD8055

Indication/Tumor Type lung adenocarcinoma

Response Type sensitive

PMIDs:
26359452

Sources:
JAX-CKB
AZD-8055 PIK3CA

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy AZD8055 + Selumetinib

Indication/Tumor Type colorectal cancer

Response Type sensitive

PMIDs:
28446642 22271687

Sources:
JAX-CKB
AZD-8055 PTEN

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type head and neck squamous cell carcinoma

Response Type predicted – sensitive

Approval Status Preclinical - Cell culture

PMIDs:
28446642

Sources:
JAX-CKB
AZD-8055 ERBB2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type breast cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
25436981

Sources:
JAX-CKB

MyCancerGenome: AZD8055
- Version: 20-Jun-2017
Alternate Names:

AZD8055 Development Name

Drug Info:

Drug Class Kinase Inhibitors

Notes TORC1/2, catalytic inhibitor

Notes catalytic inhibitor

Publications:
DTC: AZD-8055
- Version: 02-September-2020
Alternate Names:

CHEMBL1801204 ChEMBL Drug ID

Drug Info:

Publications:

Pike et al., 2013, Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014., Bioorg. Med. Chem. Lett.

JAX-CKB: AZD8055

Version: 27-September-2017

Alternate Names:

Drug Info:

Publications:

Kiessling et al., 2015, Mutant HRAS as novel target for MEK and mTOR inhibitors., Oncotarget

Holt et al., 2012, Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055)., Cancer Res.

Hayes et al., 2016, Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression., Cancer Cell

ChemblDrugs: chembl:CHEMBL1801204
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1801204
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Indication/Tumor Type	breast cancer
Response Type	sensitive
Approval Status	Preclinical

combination therapy	AZD8055 + Binimetinib
Indication/Tumor Type	lung squamous cell carcinoma
Response Type	sensitive

Direct Interaction	yes
Mechanism of Interaction	Serine/threonine-protein kinase mTOR inhibitor

Approval Status	Preclinical - Cell culture
Indication/Tumor Type	pancreatic ductal adenocarcinoma
combination therapy	AZD8055 + SCH772984

combination therapy	AZD4547 + AZD8055
Indication/Tumor Type	lung adenocarcinoma
Response Type	sensitive

combination therapy	AZD8055 + Selumetinib
Indication/Tumor Type	colorectal cancer
Response Type	sensitive

Indication/Tumor Type	head and neck squamous cell carcinoma
Response Type	predicted – sensitive
Approval Status	Preclinical - Cell culture

AZD-8055 Drug Record

AZD-8055 chembl:CHEMBL1801204 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23375793

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type breast cancer Response Type sensitive Approval Status Preclinical

PMIDs: 25436981

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: combination therapy AZD8055 + Binimetinib Indication/Tumor Type lung squamous cell carcinoma Response Type sensitive

PMIDs: 26544513

Sources: JAX-CKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase mTOR inhibitor

PMIDs: 23375793

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Approval Status Preclinical - Cell culture Indication/Tumor Type pancreatic ductal adenocarcinoma combination therapy AZD8055 + SCH772984

PMIDs: 26725216 22271687 24791855

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: combination therapy AZD4547 + AZD8055 Indication/Tumor Type lung adenocarcinoma Response Type sensitive

PMIDs: 26359452

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: combination therapy AZD8055 + Selumetinib Indication/Tumor Type colorectal cancer Response Type sensitive

PMIDs: 28446642 22271687

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type head and neck squamous cell carcinoma Response Type predicted – sensitive Approval Status Preclinical - Cell culture

PMIDs: 28446642

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type breast cancer Response Type sensitive Approval Status Preclinical

PMIDs: 25436981

Sources: JAX-CKB

MyCancerGenome: AZD8055

Alternate Names: AZD8055 Development Name

Drug Info: Drug Class Kinase Inhibitors Notes TORC1/2, catalytic inhibitor Notes catalytic inhibitor

Publications:

DTC: AZD-8055

Alternate Names: CHEMBL1801204 ChEMBL Drug ID

Drug Info:

Publications: Pike et al., 2013, Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014., Bioorg. Med. Chem. Lett.

JAX-CKB: AZD8055

Alternate Names:

Drug Info:

ChemblDrugs: chembl:CHEMBL1801204

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

n/a

PMIDs:
23375793

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type breast cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
25436981

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy AZD8055 + Binimetinib

Indication/Tumor Type lung squamous cell carcinoma

Response Type sensitive

PMIDs:
26544513

Sources:
JAX-CKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase mTOR inhibitor

PMIDs:
23375793

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Approval Status Preclinical - Cell culture

Indication/Tumor Type pancreatic ductal adenocarcinoma

combination therapy AZD8055 + SCH772984

PMIDs:
26725216 22271687 24791855

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy AZD4547 + AZD8055

Indication/Tumor Type lung adenocarcinoma

Response Type sensitive

PMIDs:
26359452

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy AZD8055 + Selumetinib

Indication/Tumor Type colorectal cancer

Response Type sensitive

PMIDs:
28446642 22271687

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type head and neck squamous cell carcinoma

Response Type predicted – sensitive

Approval Status Preclinical - Cell culture

PMIDs:
28446642

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type breast cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
25436981

Sources:
JAX-CKB

Alternate Names:

AZD8055 Development Name

Drug Info:

Drug Class Kinase Inhibitors

Notes TORC1/2, catalytic inhibitor

Notes catalytic inhibitor

Alternate Names:

CHEMBL1801204 ChEMBL Drug ID

Publications:

Pike et al., 2013, Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014., Bioorg. Med. Chem. Lett.