DGIdb - CANDOXATRIL Drug Record

CANDOXATRIL chembl:CHEMBL35084

Alternate Names:

CANDOXATRIL
UK-79300
4-({1-[(S)-2-(INDAN-5-YLOXYCARBONYL)-3-(2-METHOXY-ETHOXY)-PROPYL]-CYCLOPENTANECARBONYL}-AMINO)-CYCLOHEXANECARBOXYLIC ACID
[4(S)-CIS]-4-[[[1-[3-[(2,3-DIHYDRO-1H-INDEB5-YL)OXY]-2-[(2-METHOXYETHOXY)METHYL]-3-OXOPROPYL]CYCLOPENTYL]CARBONYL]AMINO]CYCLOHEXANECARBOXYLIC ACID
chembl:CHEMBL35084
drugbank:00616
pubchem.compound:5362417
chemidplus:123122-55-4

Drug Info:

FDA Approval	1995
Drug Class	small molecule
Drug Indications	Antihypertensive Agents
Drug Class	antihypertensive agents
Year of Approval	1995

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Publications:

Dumoulin et al., 2001, Comparison of a vasopeptidase inhibitor with neutral endopeptidase and angiotensin-converting enzyme inhibitors on bradykinin metabolism in the rat coronary bed., J. Cardiovasc. Pharmacol.
Kostova et al., 2005, Dual inhibition of angiotensin converting enzyme and neutral endopeptidase produces effective blood pressure control in spontaneously hypertensive rats., Bratisl Lek Listy
Plamboeck et al., 2005, Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig., Diabetologia
O'Connell et al., 1992, Candoxatril, an orally active neutral endopeptidase inhibitor, raises plasma atrial natriuretic factor and is natriuretic in essential hypertension., J. Hypertens.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Sansoè et al., 2006, Overexpression of kidney neutral endopeptidase (EC 3.4.24.11) and renal function in experimental cirrhosis., Am. J. Physiol. Renal Physiol.
Elsner et al., 1992, Effectiveness of endopeptidase inhibition (candoxatril) in congestive heart failure., Am. J. Cardiol.
Hirata et al., 1994, Mechanisms of the natriuretic effects of neutral endopeptidase inhibition in Dahl salt-sensitive and salt-resistant rats., J. Cardiovasc. Pharmacol.

CANDOXATRIL MME

Interaction Score: 34.78

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16025254 1315825 11752352 16449355 1386491 7511759

Sources:
TdgClinicalTrial TEND TTD
CANDOXATRIL ACE

Interaction Score: 2.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11300648 16642666

Sources:
TdgClinicalTrial TEND

TEND: CANDOXATRIL
- Version: 01-August-2011
Alternate Names:

CANDOXATRIL Primary Drug Name

Drug Info:

Year of Approval 1995

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: CANDOXATRIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Class small molecule

FDA Approval 1995

Publications:
TTD: Candoxatril
- Version: 2020.06.01
Alternate Names:

D0WF7K TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL35084
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

CANDOXATRIL Drug Record

CANDOXATRIL chembl:CHEMBL35084

Alternate Names:

Drug Info:

Publications:

CANDOXATRIL MME

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 16025254 1315825 11752352 16449355 1386491 7511759

Sources: TdgClinicalTrial TEND TTD

CANDOXATRIL ACE

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11300648 16642666

Sources: TdgClinicalTrial TEND

TEND: CANDOXATRIL

Alternate Names: CANDOXATRIL Primary Drug Name

Drug Info: Year of Approval 1995 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: CANDOXATRIL

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Class small molecule FDA Approval 1995

Publications:

TTD: Candoxatril

Alternate Names: D0WF7K TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL35084

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16025254 1315825 11752352 16449355 1386491 7511759

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11300648 16642666

Sources:
TdgClinicalTrial TEND

Alternate Names:

CANDOXATRIL Primary Drug Name

Drug Info:

Year of Approval 1995

Drug Class antihypertensive agents

Drug Info:

Drug Indications Antihypertensive Agents

Drug Class small molecule

FDA Approval 1995

Alternate Names:

D0WF7K TTD Drug ID