DGIdb - DEZOCINE Drug Record

DEZOCINE chembl:CHEMBL1685 Approved

Alternate Names:

DEZOCINE
WY-16225
DALGAN
DEZOCINUM
DEZOCINA
(-)-13BETA-AMINO-5,6,7,8,9,10,11ALPHA,12-OCTAHYDRO-5ALPHA-METHYL-5,11-METHANOBENZOCYCLODECEN-3-OL
pubchem.compound:3033053
chembl:CHEMBL1685
drugbank:01209
rxcui:22713
chemidplus:53648-55-8

Drug Info:

Year of Approval	1989
Drug Class	analgesics, opioid
FDA Approval	1989
Drug Class	small molecule
Drug Indications	Analgesics, Opioid

(1 More Sources)

Publications:

Picker, 1997, Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists., J. Pharmacol. Exp. Ther.
Cook et al., 2000, Sex-related differences in the antinociceptive effects of opioids: importance of rat genotype, nociceptive stimulus intensity, and efficacy at the mu opioid receptor., Psychopharmacology (Berl.)
Morgan et al., 1999, An examination of the interactions between the antinociceptive effects of morphine and various mu-opioids: the role of intrinsic efficacy and stimulus intensity., Anesth. Analg.
Barrett et al., 2001, Importance of sex and relative efficacy at the mu opioid receptor in the development of tolerance and cross-tolerance to the antinociceptive effects of opioids., Psychopharmacology (Berl.)
Gharagozlou et al., 2003, Activity of opioid ligands in cells expressing cloned mu opioid receptors., BMC Pharmacol.
Jacobs et al., 1992, Opioid receptor affinity for agonist-antagonist analgesics., J Am Podiatr Med Assoc
Gharagozlou et al., 2006, Pharmacological profiles of opioid ligands at kappa opioid receptors., BMC Pharmacol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

DEZOCINE OPRK1

Interaction Score: 3.64

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Kappa opioid receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
16433932 17016423 17139284 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
DEZOCINE OPRM1

Interaction Score: 2.68

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Mu opioid receptor partial agonist

Trial Name -

PMIDs:
9399970 10958085 9972766 11702089 12513698 1361946

Sources:
TdgClinicalTrial ChemblInteractions TEND

TEND: DEZOCINE
- Version: 01-August-2011
Alternate Names:

DEZOCINE Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Year of Approval 1989

Publications:
TdgClinicalTrial: DEZOCINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Analgesics, Opioid

Drug Class small molecule

FDA Approval 1989

Publications:
TTD: Dezocine
- Version: 2020.06.01
Alternate Names:

D0P6VV TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1685
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1685
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Kappa opioid receptor antagonist
Direct Interaction	yes
Trial Name	-

Direct Interaction	yes
Mechanism of Interaction	Mu opioid receptor partial agonist
Trial Name	-

DEZOCINE Drug Record

DEZOCINE chembl:CHEMBL1685 Approved

Alternate Names:

Drug Info:

Publications:

DEZOCINE OPRK1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Kappa opioid receptor antagonist Direct Interaction yes Trial Name -

PMIDs: 16433932 17016423 17139284 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

DEZOCINE OPRM1

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Mu opioid receptor partial agonist Trial Name -

PMIDs: 9399970 10958085 9972766 11702089 12513698 1361946

Sources: TdgClinicalTrial ChemblInteractions TEND

TEND: DEZOCINE

Alternate Names: DEZOCINE Primary Drug Name

Drug Info: Drug Class analgesics, opioid Year of Approval 1989

Publications:

TdgClinicalTrial: DEZOCINE

Alternate Names:

Drug Info: Drug Indications Analgesics, Opioid Drug Class small molecule FDA Approval 1989

Publications:

TTD: Dezocine

Alternate Names: D0P6VV TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1685

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1685

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Kappa opioid receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
16433932 17016423 17139284 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Mu opioid receptor partial agonist

Trial Name -

PMIDs:
9399970 10958085 9972766 11702089 12513698 1361946

Sources:
TdgClinicalTrial ChemblInteractions TEND

Alternate Names:

DEZOCINE Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Year of Approval 1989

Drug Info:

Drug Indications Analgesics, Opioid

Drug Class small molecule

FDA Approval 1989

Alternate Names:

D0P6VV TTD Drug ID