DGIdb - DIGOXIN Drug Record

DIGOXIN chembl:CHEMBL1751 Approved

Alternate Names:

DIGOXIN PEDIATRIC
NSC-95100
DIGAMEX
LANOXIN-PG
VANOXIN
LANOXIN
LANOXIN PEDIATRIC
LANOXICAPS
DIGOXIN
LANOXIN-125
EUDIGOX
LANACRIST
DIGOSSINA
DIGOXINUM
DIGITALIS GLYCOSIDE
ROUGOXIN
HOMOLLE'S DIGITALIN
NEO-LANICOR
COGOXIN
LANICOR
12Β-HYDROXYDIGITOXIN
12BETA-HYDROXYDIGITOXIN
SK-DIGOXIN
DILANACIN
DYNAMOS
DIGOXINA
CARDOXIN
DIGACIN
DGO621
LANADICOR
DIGOXINE
DIGAZOLAN
DAVOXIN
chembl:CHEMBL1751
rxcui:3407
chemidplus:20830-75-5
drugbank:00390
pubchem.compound:2724385

Drug Info:

Year of Approval	approved before 1982
Drug Class	cardiotonic agents
Drug Class	anti-arrhythmia agents
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Cardiotonic Agents
Drug Indications	Anti-Arrhythmia Agents

(4 More Sources)

Publications:

Ke et al., 2000, Effect of anti-digoxin antiserum on endoxin and membrane ATPase activity in hypoxia-reoxygenation induced myocardial injury., Acta Pharmacol. Sin.
Aizman et al., 2001, Ouabain, a steroid hormone that signals with slow calcium oscillations., Proc. Natl. Acad. Sci. U.S.A.
Kumar et al., 2001, A hypothalamic digoxin mediated model for conscious and subliminal perception., J Neural Transm (Vienna)
Chen et al., 2001, Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells., Br. J. Pharmacol.
Ravikumar et al., 2000, Isoprenoid pathway and free radical generation and damage in neuropsychiatric disorders., Indian J. Exp. Biol.
Han et al., 2006, Effects of capsaicin on P-gp function and expression in Caco-2 cells., Biochem. Pharmacol.
Sakaeda et al., 2005, Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs., J. Pharm. Pharmacol.
Buchhorn et al., 2003, Effects of therapeutic beta blockade on myocardial function and cardiac remodelling in congenital cardiac disease., Cardiol Young
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Garcia et al., 2007, Estimation of the glomerular filtration rate from serum creatinine and cystatin C with regard to therapeutic digoxin monitoring., J Clin Pharmacol
Vinge et al., 1993, Effects of adrenal function tests on the levels of endogenous digitalis-like substances and some pituitary hormones., Acta Endocrinol.
Kim KM et al., 2012, Pharmacogenetics and healthcare outcomes in patients with chronic heart failure., Eur J Clin Pharmacol
Valdemarsson et al., 1991, Increased plasma level of substance P in patients with severe congestive heart failure treated with ACE inhibitors., J. Intern. Med.
Maigaard et al., Digoxin inhibition of relaxation induced by prostacyclin and vasoactive intestinal polypeptide in small human placental arteries., Placenta

DIGOXIN CST3

Interaction Score: 1.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17698593

Sources:
NCI
DIGOXIN SLCO4C1

Interaction Score: 1.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DIGOXIN ATP1A1

Interaction Score: 1.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
11324464 11687608 11515751 11309248 11272406

Sources:
TdgClinicalTrial ChemblInteractions TEND
DIGOXIN VIP

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3906626

Sources:
NCI
DIGOXIN ATP1A4

Interaction Score: 0.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIGOXIN ATP1B3

Interaction Score: 0.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIGOXIN ATP1B1

Interaction Score: 0.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIGOXIN ATP1B2

Interaction Score: 0.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIGOXIN ATP1A3

Interaction Score: 0.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DIGOXIN ATP1A2

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIGOXIN FXYD2

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DIGOXIN TSHB

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8383398

Sources:
NCI
DIGOXIN CCN2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12691286

Sources:
NCI
DIGOXIN NOS3

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543981

Sources:
PharmGKB
DIGOXIN TAC1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1717629

Sources:
NCI
DIGOXIN STAT3

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGOXIN ADRB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543981

Sources:
PharmGKB
DIGOXIN ADRB2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543981

Sources:
PharmGKB
DIGOXIN PAX8

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGOXIN TNF

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGOXIN ABCB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16674925 15969931

Sources:
NCI
DIGOXIN RORC

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGOXIN RGS4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGOXIN NR3C1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGOXIN CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DIGOXIN CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DIGOXIN CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DIGOXIN CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DIGOXIN ATAD5

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGOXIN IDH1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGOXIN CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DIGOXIN GMNN

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGOXIN NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGOXIN AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: DIGOXIN
- Version: 01-August-2011
Alternate Names:

DIGOXIN Primary Drug Name

Drug Info:

Drug Class anti-arrhythmia agents

Drug Class cardiotonic agents

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: DIGOXIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Indications Cardiotonic Agents

Drug Class small molecule

Publications:
DTC: DIGOXIN
- Version: 02-September-2020
Alternate Names:

CHEMBL1751 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

NCI: DIGOXIN

Version: 14-September-2017

Alternate Names:

C28990 NCI drug code

Drug Info:

Publications:

Vinge et al., 1993, Effects of adrenal function tests on the levels of endogenous digitalis-like substances and some pituitary hormones., Acta Endocrinol.

Valdemarsson et al., 1991, Increased plasma level of substance P in patients with severe congestive heart failure treated with ACE inhibitors., J. Intern. Med.

Maigaard et al., Digoxin inhibition of relaxation induced by prostacyclin and vasoactive intestinal polypeptide in small human placental arteries., Placenta

PharmGKB: digoxin
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Kim KM et al., 2012, Pharmacogenetics and healthcare outcomes in patients with chronic heart failure., Eur J Clin Pharmacol
TTD: Digoxin
- Version: 2020.06.01
Alternate Names:

D02OZE TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL1751
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1751
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-
Mechanism of Interaction	Sodium/potassium-transporting ATPase inhibitor

Mechanism of Interaction	Sodium/potassium-transporting ATPase inhibitor
Direct Interaction	yes

DIGOXIN Drug Record

DIGOXIN chembl:CHEMBL1751 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17698593

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs: 11324464 11687608 11515751 11309248 11272406

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3906626

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8383398

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12691286

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543981

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1717629

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543981

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543981

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
17698593

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
11324464 11687608 11515751 11309248 11272406

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
3906626

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
8383398

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12691286

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22543981

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
1717629

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22543981

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22543981

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16674925 15969931

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC