DGIdb - ATP1A1 Gene Record

ATP1A1 476 Druggable GenomeClinically Actionable

Alternate Names:

476
ATPASE NA+/K+ TRANSPORTING SUBUNIT ALPHA 1
ATP1A1
182310
799
ENSG00000163399
OTTHUMG00000012109
Sodium pump subunit alpha-1
Sodium/potassium-transporting ATPase subunit alpha-1
Na(+)/K(+) ATPase alpha-1 subunit
P05023
AT1A1_HUMAN
SODIUM/POTASSIUM-TRANSPORTING ATPASE ALPHA-1 CHAIN PRECURSOR (EC 3.6.3.9) (SODIUM PUMP 1) (NA+/K+ ATPASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P05023]
PA62
T40800
CMT2DD
HOMGSMR2

Gene Info:

Target Subclass	Active_transporters
Transmembrane Helix Count	8
Target Subclass	P-ATPase
Target Main Class	Transporters
Target Class	transporter
Target Subclass	TC:3.A.3.1.1
Target Class	Transporters
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	ION CHANNEL
Interpro Acc	IPR004014
Interpro Type	Family
Interpro Short Name	ATPase_P-typ_cation-exchng_asu
Uniprot Status	Swiss-Prot
Interpro Short Name	ATPase_P-typ_cation-transptr_N
Interpro Name	ATPase, P-type cation-transporter, C-terminal
Interpro Type	Domain
Interpro Name	ATPase, P-type cation exchange, alpha subunit
Interpro Name	ATPase, P-type cation-transporter, N-terminal
Interpro Acc	IPR006069
Human Readable Name	TRANSPORTER
Interpro Short Name	ATPase_P-typ_cation-transptr_C
Interpro Acc	IPR006068
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

TRANSPORTER
ION CHANNEL
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Mattera GG et al., 2007, Istaroxime: a new luso-inotropic agent for heart failure., Am J Cardiol
Ke et al., 2000, Effect of anti-digoxin antiserum on endoxin and membrane ATPase activity in hypoxia-reoxygenation induced myocardial injury., Acta Pharmacol. Sin.
Aizman et al., 2001, Ouabain, a steroid hormone that signals with slow calcium oscillations., Proc. Natl. Acad. Sci. U.S.A.
Kumar et al., 2001, A hypothalamic digoxin mediated model for conscious and subliminal perception., J Neural Transm (Vienna)
Chen et al., 2001, Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells., Br. J. Pharmacol.
Ravikumar et al., 2000, Isoprenoid pathway and free radical generation and damage in neuropsychiatric disorders., Indian J. Exp. Biol.
González-García et al., 1987, Characterization of the alpha +-like Na+,K+-ATPase which mediates ouabain inhibition of adrenergic induction of N-acetyltransferase (EC 2.3.1.87) activity: studies with isolated pinealocytes., Mol. Pharmacol.
Rigoulet, 1990, Control processes in oxidative phosphorylation: kinetic constraints and stoichiometry., Biochim. Biophys. Acta
Rigoulet et al., 1989, Almitrine, a new kind of energy-transduction inhibitor acting on mitochondrial ATP synthase., Biochim. Biophys. Acta
Rigoulet et al., 1990, Flux-dependent increase in the stoichiometry of charge translocation by mitochondrial ATPase/ATP synthase induced by almitrine., Biochim. Biophys. Acta
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Benzi et al., 1993, Synaptosomal non-mitochondrial ATPase activities and drug treatment., Neurochem. Res.
Zhao et al., 2006, Study on cardioactive effects of brazilein., Pharmacology
Kovacic et al., 1992, Inhibition of sodium pump by bepridil. An in vitro and microcalorimetric study., Biochem. Pharmacol.
Raess et al., 1990, Inhibition of erythrocyte Ca2(+)-pump by Ca2+ antagonists., Biochem. Pharmacol.
Smith et al., 1990, The effects of reported Ca2+ sensitisers on the rates of Ca2+ release from cardiac troponin C and the troponin-tropomyosin complex., Br. J. Pharmacol.
Lamers et al., 1985, Slow calcium channel blockers and calmodulin. Effect of felodipine, nifedipine, prenylamine and bepridil on cardiac sarcolemmal calcium pumping ATPase., Biochem. Pharmacol.
Fuchs et al., 1986, Effects of bepridil on heart mitochondrial membrane and the isolated rat heart preparation., Arzneimittelforschung
Marcus et al., 1975, The reactivity of derivatives of digoxin and digitoxin as measured by the Na-K-atpase displacement assay and by radioimmunoassay., J. Lab. Clin. Med.
Prignitz et al., 1976, [Influence of roentgen rays on electrolyte changes and metabolism of the myocardium. VII. Radiation-induced inhibition of the sodium- and potassium--activated microscomal-trasport ATPase]., Strahlentherapie
Bluschke et al., 1976, Increase in the (Na+ + K+)-ATPase activity in heart muscle after chronic treatment with digitoxin or potassium deficient diet., Eur. J. Pharmacol.
Fricke, 1976, [New aspects on the mode of action of cardiac glycosides]., Fortschr. Med.
Hauck et al., 2009, Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1., Eur. J. Pharmacol.
Almotrefi et al., 1999, Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase., Can. J. Physiol. Pharmacol.
Mentré et al., 1999, An unexpected effect of an ouabain-sensitive ATPase activity on the amount of antigen-antibody complexes formed in situ., Cell. Mol. Biol. (Noisy-le-grand)
Tao et al., 1999, Sodium pump inhibition and regional expression of sodium pump alpha-isoforms in lens., Hypertension
Hawke et al., 1999, K+ transport in resting rat hind-limb skeletal muscle in response to paraxanthine, a caffeine metabolite., Can. J. Physiol. Pharmacol.
Qazzaz et al., 1999, Two biologically active isomers of dihydroouabain isolated from a commercial preparation., Biochim. Biophys. Acta
Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics

ALMITRINE ATP1A1

Interaction Score: 41.22

Interaction Types & Directionality:

binder

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2144185 2527061 2165421 11752352 8099718

Sources:
TdgClinicalTrial TEND TTD
EPLERENONE ATP1A1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23788015

Sources:
PharmGKB
OUABAIN ATP1A1

Interaction Score: 5.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10593659 10541475 11752352 10567200 10593655 10564763

Sources:
TdgClinicalTrial TEND TTD
ISTAROXIME ATP1A1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name istaroxime, Debio 0614, ST-2744

Novel drug target Established target

PMIDs:
17239702

Sources:
TdgClinicalTrial
BEPRIDIL ATP1A1

Interaction Score: 3.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1329768 2148481 2207500 2933041 2938592

Sources:
TdgClinicalTrial TEND
DESLANOSIDE ATP1A1

Interaction Score: 3.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
16319518 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ACETYLDIGITOXIN ATP1A1

Interaction Score: 3.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
2826993

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
DIGITOXIN ATP1A1

Interaction Score: 2.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Trial Name -

PMIDs:
123547 131389 132355 136410 19751721 11309248

Sources:
TdgClinicalTrial ChemblInteractions TEND
CHLOROPROCAINE ATP1A1

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LUMEFANTRINE ATP1A1

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DIGOXIN ATP1A1

Interaction Score: 1.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
11324464 11687608 11515751 11309248 11272406

Sources:
TdgClinicalTrial ChemblInteractions TEND
ARTEMETHER ATP1A1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000163399
- Version: 101_38
Alternate Names:

ATP1A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P05023
- Version: 01-August-2011
Alternate Names:

ATP1A1 Gene Symbol

ENSG00000163399 Ensembl Gene Id

476 Entrez Gene Id

Gene Info:

Target Subclass Active_transporters

Transmembrane Helix Count 8

Target Subclass P-ATPase

Publications:

RussLampel: ENSG00000163399

Version: 26-July-2011

Alternate Names:

ENSG00000163399 Ensembl Gene Id

SODIUM/POTASSIUM-TRANSPORTING ATPASE ALPHA-1 CHAIN PRECURSOR (EC 3.6.3.9) (SODIUM PUMP 1) (NA+/K+ ATPASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P05023] Description

ATP1A1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P05023
- Version: January-2014
Alternate Names:

ATP1A1 Gene Symbol

Gene Info:

Target Class transporter

Target Subclass TC:3.A.3.1.1

Target Class Transporters

Publications:
HopkinsGroom: P05023
- Version: 11-September-2012
Alternate Names:

ATP1A1 Uniprot Gene Name

476 Entrez Gene Id

ENSG00000163399 Ensembl Gene Id

Gene Info:

Human Readable Name ION CHANNEL

Interpro Acc IPR004014

Interpro Type Family

Gene Categories:

TRANSPORTER, ION CHANNEL, DRUGGABLE GENOME

Publications:
PharmGKB: ATP1A1
- Version: 18-August-2020
Alternate Names:

PA62 PharmGKB ID

Gene Info:

Publications:

Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics
HingoraniCasas: ENSG00000163399
- Version: 31-May-2017
Alternate Names:

ENSG00000163399 Gene Symbol

ATP1A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ATP1A1
- Version: chembl_23
Alternate Names:

ATP1A1 GENE_SYMBOL

Sodium/potassium-transporting ATPase subunit alpha-1 UNIPROT

Sodium pump subunit alpha-1 UNIPROT

Gene Info:

Publications:
TTD: Sodium pump subunit alpha-1
- Version: 2020.06.01
Alternate Names:

ATP1A1 TTD Gene Abbreviation

T40800 TTD Target ID

Gene Info:

Publications:
Pharos: ATP1A1
- Version: 01-February-2022
Alternate Names:

Sodium/potassium-transporting ATPase subunit alpha-1 Gene Name

P05023 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
CarisMolecularIntelligence: ATP1A1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Trial Name	istaroxime, Debio 0614, ST-2744
Novel drug target	Established target

Direct Interaction	yes
Mechanism of Interaction	Sodium/potassium-transporting ATPase inhibitor
Trial Name	-

ATP1A1	Gene Symbol
ENSG00000163399	Ensembl Gene Id
476	Entrez Gene Id

ATP1A1	Uniprot Gene Name
476	Entrez Gene Id
ENSG00000163399	Ensembl Gene Id

ATP1A1	GENE_SYMBOL
Sodium/potassium-transporting ATPase subunit alpha-1	UNIPROT
Sodium pump subunit alpha-1	UNIPROT

Sodium/potassium-transporting ATPase subunit alpha-1	Gene Name
P05023	UniProt ID

ATP1A1 Gene Record

ATP1A1 476 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: binder

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2144185 2527061 2165421 11752352 8099718

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23788015

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10593659 10541475 11752352 10567200 10593655 10564763

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name istaroxime, Debio 0614, ST-2744 Novel drug target Established target

PMIDs: 17239702

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1329768 2148481 2207500 2933041 2938592

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs: 16319518 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs: 2826993

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor Trial Name -

PMIDs: 123547 131389 132355 136410 19751721 11309248

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs: 11324464 11687608 11515751 11309248 11272406

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Ensembl: ENSG00000163399

Alternate Names: ATP1A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P05023

Alternate Names: ATP1A1 Gene Symbol ENSG00000163399 Ensembl Gene Id 476 Entrez Gene Id

Gene Info: Target Subclass Active_transporters Transmembrane Helix Count 8 Target Subclass P-ATPase

Publications:

RussLampel: ENSG00000163399

Alternate Names: ENSG00000163399 Ensembl Gene Id SODIUM/POTASSIUM-TRANSPORTING ATPASE ALPHA-1 CHAIN PRECURSOR (EC 3.6.3.9) (SODIUM PUMP 1) (NA+/K+ ATPASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P05023] Description ATP1A1 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P05023

Alternate Names: ATP1A1 Gene Symbol

Gene Info: Target Class transporter Target Subclass TC:3.A.3.1.1 Target Class Transporters

Publications:

HopkinsGroom: P05023

Alternate Names: ATP1A1 Uniprot Gene Name 476 Entrez Gene Id ENSG00000163399 Ensembl Gene Id

Gene Info: Human Readable Name ION CHANNEL Interpro Acc IPR004014 Interpro Type Family

Gene Categories: TRANSPORTER, ION CHANNEL, DRUGGABLE GENOME

Publications:

PharmGKB: ATP1A1

Alternate Names: PA62 PharmGKB ID

Gene Info:

Publications: Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics

Interaction Types & Directionality:

binder

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2144185 2527061 2165421 11752352 8099718

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
23788015

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10593659 10541475 11752352 10567200 10593655 10564763

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name istaroxime, Debio 0614, ST-2744

Novel drug target Established target

PMIDs:
17239702

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1329768 2148481 2207500 2933041 2938592

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
16319518 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
2826993

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Trial Name -

PMIDs:
123547 131389 132355 136410 19751721 11309248

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
11324464 11687608 11515751 11309248 11272406

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

ATP1A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ATP1A1 Gene Symbol

ENSG00000163399 Ensembl Gene Id

476 Entrez Gene Id

Gene Info:

Target Subclass Active_transporters

Transmembrane Helix Count 8

Target Subclass P-ATPase

Alternate Names:

ENSG00000163399 Ensembl Gene Id

SODIUM/POTASSIUM-TRANSPORTING ATPASE ALPHA-1 CHAIN PRECURSOR (EC 3.6.3.9) (SODIUM PUMP 1) (NA+/K+ ATPASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P05023] Description

ATP1A1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ATP1A1 Gene Symbol

Gene Info:

Target Class transporter

Target Subclass TC:3.A.3.1.1

Target Class Transporters

Alternate Names:

ATP1A1 Uniprot Gene Name

476 Entrez Gene Id

ENSG00000163399 Ensembl Gene Id

Gene Info:

Human Readable Name ION CHANNEL

Interpro Acc IPR004014

Interpro Type Family

Gene Categories:

TRANSPORTER, ION CHANNEL, DRUGGABLE GENOME

Alternate Names:

PA62 PharmGKB ID

Publications:

Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics

Alternate Names:

ENSG00000163399 Gene Symbol

ATP1A1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ATP1A1 GENE_SYMBOL

Sodium/potassium-transporting ATPase subunit alpha-1 UNIPROT

Sodium pump subunit alpha-1 UNIPROT

Alternate Names:

ATP1A1 TTD Gene Abbreviation

T40800 TTD Target ID

Alternate Names:

Sodium/potassium-transporting ATPase subunit alpha-1 Gene Name

P05023 UniProt ID

Gene Categories:

ENZYME

Gene Categories:

CLINICALLY ACTIONABLE