DGIdb - DROPERIDOL Drug Record

DROPERIDOL chembl:CHEMBL1108 Approved

Alternate Names:

INAPSINE
R-4749
DRIDOL
DROLEPTAN
DROPERIDOL
MCN-JR-4749
NSC-169874
DROPERIDOLO
1-(1-(4-(P-FLUOROPHENYL)-4-OXOBUTYL)-1,2,3,6-TETRAHYDRO-4-PYRIDYL)-2-BENZIMIDAZOLINONE
1-{1-[4-(4-FLUORO-PHENYL)-4-OXO-BUTYL]-1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL}-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONE
1-{1-[4-(4-FLUOROPHENYL)-4-OXOBUTYL]-1,2,3,6-TETRAHYDRO-4-PYRIDINYL}-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-2-ONE
DROPÉRIDOL
DROPERIDOLUM
DROLEPTAN®
1-(1-(3-(P-FLUOROBENZOYL)PROPYL)-1,2,3,6-TETRAHYDRO-4-PYRIDYL)-2-BENZIMIDAZOLINONE
INAPSINE®
drugbank:00450
pubchem.compound:3168
chemidplus:548-73-2
rxcui:3648
chembl:CHEMBL1108

Drug Info:

Year of Approval	approved before 1982
Drug Class	adjuvants, anesthesia
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Adjuvants, Anesthesia

(3 More Sources)

Publications:

Roden DM, 2004, Drug-induced prolongation of the QT interval., N Engl J Med
Larson, 2003, The effect of antiemetics on pupillary reflex dilation during epidural/general anesthesia., Anesth. Analg.
Gao et al., 2010, The effect of dopamine on pain-related neurons in the parafascicular nucleus of rats., J Neural Transm (Vienna)
Grip et al., 1992, Histopathology and evaluation of potentiation of morphine-induced antinociception by intrathecal droperidol in the rat., Acta Anaesthesiol Scand
Hamik et al., 1989, Differential interactions of traditional and novel antiemetics with dopamine D2 and 5-hydroxytryptamine3 receptors., Cancer Chemother. Pharmacol.

DROPERIDOL DRD2

Interaction Score: 0.5

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
14633536 20358234 1549935 2527092

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
DROPERIDOL DRD4

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DROPERIDOL DRD3

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DROPERIDOL HTR2A

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
DROPERIDOL KCNH2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14999113

Sources:
PharmGKB
DROPERIDOL CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: DROPERIDOL
- Version: 01-August-2011
Alternate Names:

DROPERIDOL Primary Drug Name

Drug Info:

Drug Class adjuvants, anesthesia

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: DROPERIDOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Adjuvants, Anesthesia

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
PharmGKB: droperidol
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Roden DM, 2004, Drug-induced prolongation of the QT interval., N Engl J Med
TTD: Droperidol
- Version: 2020.06.01
Alternate Names:

D03CJL TTD Drug ID

Drug Info:

Publications:
DTC: DROPERIDOL
- Version: 02-September-2020
Alternate Names:

CHEMBL1108 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1108
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1108
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	D2-like dopamine receptor antagonist
Direct Interaction	yes
Trial Name	-

Direct Interaction	yes
Mechanism of Interaction	Serotonin 2a (5-HT2a) receptor antagonist

DROPERIDOL Drug Record

DROPERIDOL chembl:CHEMBL1108 Approved

Alternate Names:

Drug Info:

Publications:

DROPERIDOL DRD2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction D2-like dopamine receptor antagonist Direct Interaction yes Trial Name -

PMIDs: 14633536 20358234 1549935 2527092

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

DROPERIDOL DRD4

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction D2-like dopamine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

DROPERIDOL DRD3

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction D2-like dopamine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

DROPERIDOL HTR2A

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

PMIDs: None found

Sources: ChemblInteractions

DROPERIDOL KCNH2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14999113

Sources: PharmGKB

DROPERIDOL CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: DROPERIDOL

Alternate Names: DROPERIDOL Primary Drug Name

Drug Info: Drug Class adjuvants, anesthesia Year of Approval approved before 1982

Publications:

TdgClinicalTrial: DROPERIDOL

Alternate Names:

Drug Info: Drug Indications Adjuvants, Anesthesia Drug Class small molecule FDA Approval Approved before 1982

Publications:

PharmGKB: droperidol

Alternate Names:

Drug Info:

Publications: Roden DM, 2004, Drug-induced prolongation of the QT interval., N Engl J Med

TTD: Droperidol

Alternate Names: D03CJL TTD Drug ID

Drug Info:

Publications:

DTC: DROPERIDOL

Alternate Names: CHEMBL1108 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1108

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1108

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
14633536 20358234 1549935 2527092

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
14999113

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

DROPERIDOL Primary Drug Name

Drug Info:

Drug Class adjuvants, anesthesia

Year of Approval approved before 1982

Drug Info:

Drug Indications Adjuvants, Anesthesia

Drug Class small molecule

FDA Approval Approved before 1982

Publications:

Roden DM, 2004, Drug-induced prolongation of the QT interval., N Engl J Med

Alternate Names:

D03CJL TTD Drug ID

Alternate Names:

CHEMBL1108 ChEMBL Drug ID