DGIdb - DUTASTERIDE Drug Record

DUTASTERIDE chembl:CHEMBL1200969 Approved

Alternate Names:

AVODART
GI-198745
DUTASTERIDE
GG-745
(5ALPHA,17BETA)-N-(2,5-BIS(TRIFLUOROMETHYL)PHENYL)-3-OXO-4-AZAANDROST-1-ENE-17-CARBOXAMIDE
ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-3-OXO-4-AZA-5ALPHA-ANDROST-1-ENE-17BETA-CARBOXY-2',5'-XYLIDIDE
pubchem.compound:6918296
rxcui:228790
drugbank:01126
chemidplus:164656-23-9
chembl:CHEMBL1200969

Drug Info:

Drug Class	anti-baldness agents, antihyperplasia agents
Year of Approval	2001
FDA Approval	2001
Drug Class	small molecule
Drug Indications	Anti-baldness Agents, Antihyperplasia Agents
FDA Approval	approved
Drug Class	Small molecule
Drug Indications	for treatment of benign prostate hyperplasia

(2 More Sources)

Publications:

Smith et al., 2009, Finasteride in the treatment of patients with benign prostatic hyperplasia: a review., Ther Clin Risk Manag
Goldenberg et al., 2009, The role of 5-alpha reductase inhibitors in prostate pathophysiology: Is there an additional advantage to inhibition of type 1 isoenzyme?, Can Urol Assoc J
Aggarwal et al., 2010, An overview on 5alpha-reductase inhibitors., Steroids
Shah et al., 2009, Phase II study of Dutasteride for recurrent prostate cancer during androgen deprivation therapy., J. Urol.
Rathnayake et al., 2010, Male androgenetic alopecia., Expert Opin Pharmacother
Xu et al., 2006, Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers., Clin. Cancer Res.
Rittmaster et al., 2009, Pharmacological approaches to reducing the risk of prostate cancer., Eur. Urol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Keam et al., 2008, Dutasteride: a review of its use in the management of prostate disorders., Drugs

DUTASTERIDE SRD5A2

Interaction Score: 92.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Steroid 5-alpha-reductase inhibitor

Direct Interaction yes

Trial Name dutasteride + tamsulosin,Jalyn

PMIDs:
19707263 19543428 19879888 19091347 16818707 20426708 19200641 11752352 18318566

Sources:
TdgClinicalTrial ChemblInteractions TEND
DUTASTERIDE SRD5A1

Interaction Score: 37.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Trial Name dutasteride,Avodart

Novel drug target Established target

PMIDs:
19707263 19543428 19879888 19091347 20426708 16818707 19200641 11752352 18318566

Sources:
TdgClinicalTrial ChemblInteractions TEND
DUTASTERIDE SRD5A3

Interaction Score: 15.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Steroid 5-alpha-reductase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DUTASTERIDE AR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: DUTASTERIDE
- Version: 01-August-2011
Alternate Names:

DUTASTERIDE Primary Drug Name

Drug Info:

Year of Approval 2001

Drug Class anti-baldness agents, antihyperplasia agents

Publications:
TdgClinicalTrial: DUTASTERIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of benign prostate hyperplasia

Drug Class Small molecule

FDA Approval approved

Publications:
TTD: Dutasteride
- Version: 2020.06.01
Alternate Names:

D0A9YA TTD Drug ID

Drug Info:

Publications:
DTC: DUTASTERIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL1200969 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1200969
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1200969
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Steroid 5-alpha-reductase inhibitor
Direct Interaction	yes
Trial Name	dutasteride + tamsulosin,Jalyn

Trial Name	-
Trial Name	dutasteride,Avodart
Novel drug target	Established target

DUTASTERIDE Drug Record

DUTASTERIDE chembl:CHEMBL1200969 Approved

Alternate Names:

Drug Info:

Publications:

DUTASTERIDE SRD5A2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Steroid 5-alpha-reductase inhibitor Direct Interaction yes Trial Name dutasteride + tamsulosin,Jalyn

PMIDs: 19707263 19543428 19879888 19091347 16818707 20426708 19200641 11752352 18318566

Sources: TdgClinicalTrial ChemblInteractions TEND

DUTASTERIDE SRD5A1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Trial Name dutasteride,Avodart Novel drug target Established target

PMIDs: 19707263 19543428 19879888 19091347 20426708 16818707 19200641 11752352 18318566

Sources: TdgClinicalTrial ChemblInteractions TEND

DUTASTERIDE SRD5A3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Steroid 5-alpha-reductase inhibitor

PMIDs: None found

Sources: ChemblInteractions

DUTASTERIDE AR

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: DUTASTERIDE

Alternate Names: DUTASTERIDE Primary Drug Name

Drug Info: Year of Approval 2001 Drug Class anti-baldness agents, antihyperplasia agents

Publications:

TdgClinicalTrial: DUTASTERIDE

Alternate Names:

Drug Info: Drug Indications for treatment of benign prostate hyperplasia Drug Class Small molecule FDA Approval approved

Publications:

TTD: Dutasteride

Alternate Names: D0A9YA TTD Drug ID

Drug Info:

Publications:

DTC: DUTASTERIDE

Alternate Names: CHEMBL1200969 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1200969

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1200969

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Steroid 5-alpha-reductase inhibitor

Direct Interaction yes

Trial Name dutasteride + tamsulosin,Jalyn

PMIDs:
19707263 19543428 19879888 19091347 16818707 20426708 19200641 11752352 18318566

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Trial Name dutasteride,Avodart

Novel drug target Established target

PMIDs:
19707263 19543428 19879888 19091347 20426708 16818707 19200641 11752352 18318566

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Steroid 5-alpha-reductase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

DUTASTERIDE Primary Drug Name

Drug Info:

Year of Approval 2001

Drug Class anti-baldness agents, antihyperplasia agents

Drug Info:

Drug Indications for treatment of benign prostate hyperplasia

Drug Class Small molecule

FDA Approval approved

Alternate Names:

D0A9YA TTD Drug ID

Alternate Names:

CHEMBL1200969 ChEMBL Drug ID