DGIdb - SRD5A2 Gene Record

SRD5A2 6716 Druggable Genome

Alternate Names:

6716
STEROID 5 ALPHA-REDUCTASE 2
SRD5A2
607306
11285
ENSG00000277893
OTTHUMG00000152057
P31213
S5A2_HUMAN
3-oxo-5-alpha-steroid 4-dehydrogenase 2
S5AR 2
Type II 5-alpha reductase
Steroid 5-alpha-reductase 2
SR type 2
5 alpha-SR2
ENSG00000049319
T71390

Gene Info:

Target Subclass	1.3.99
Transmembrane Helix Count	7
Target Main Class	Enzymes
Target Class	Enzymes
Target Subclass	EC:1.3.99
Target Subclass	EC:1.3.1.30
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Bowman et al., 2003, Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat., Toxicol. Sci.
Smith et al., 2009, Finasteride in the treatment of patients with benign prostatic hyperplasia: a review., Ther Clin Risk Manag
Goldenberg et al., 2009, The role of 5-alpha reductase inhibitors in prostate pathophysiology: Is there an additional advantage to inhibition of type 1 isoenzyme?, Can Urol Assoc J
Ha et al., 2003, Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia., J. Dermatol. Sci.
Suzuki et al., 2010, Saturable binding of finasteride to steroid 5alpha-reductase as determinant of nonlinear pharmacokinetics., Drug Metab. Pharmacokinet.
Xu et al., 2006, Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers., Clin. Cancer Res.
Joseph et al., 2005, Hidradenitis suppurativa treated with finasteride., J Dermatolog Treat
Aggarwal et al., 2010, An overview on 5alpha-reductase inhibitors., Steroids
Shah et al., 2009, Phase II study of Dutasteride for recurrent prostate cancer during androgen deprivation therapy., J. Urol.
Rathnayake et al., 2010, Male androgenetic alopecia., Expert Opin Pharmacother
Rittmaster et al., 2009, Pharmacological approaches to reducing the risk of prostate cancer., Eur. Urol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Keam et al., 2008, Dutasteride: a review of its use in the management of prostate disorders., Drugs

DUTASTERIDE SRD5A2

Interaction Score: 92.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Steroid 5-alpha-reductase inhibitor

Direct Interaction yes

Trial Name dutasteride + tamsulosin,Jalyn

PMIDs:
19707263 19543428 19879888 19091347 16818707 20426708 19200641 11752352 18318566

Sources:
TdgClinicalTrial ChemblInteractions TEND
FINASTERIDE SRD5A2

Interaction Score: 23.78

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Steroid 5-alpha-reductase 2 inhibitor

Trial Name YM-152, finasteride

PMIDs:
12773767 19707263 19543428 12670724 20460827 16818707 16019620

Sources:
TdgClinicalTrial ChemblInteractions TTD

Ensembl: ENSG00000277893
- Version: 101_38
Alternate Names:

SRD5A2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P31213
- Version: 01-August-2011
Alternate Names:

S5A2_HUMAN Uniprot Id

6716 Entrez Gene Id

SRD5A2 Gene Symbol

Gene Info:

Target Subclass 1.3.99

Transmembrane Helix Count 7

Target Main Class Enzymes

Publications:
TdgClinicalTrial: P31213
- Version: January-2014
Alternate Names:

SRD5A2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.3.99

Target Subclass EC:1.3.1.30

Publications:
ChemblInteractions: SRD5A2
- Version: chembl_23
Alternate Names:

SRD5A2 GENE_SYMBOL

3-oxo-5-alpha-steroid 4-dehydrogenase 2 UNIPROT

5 alpha-SR2 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000049319
- Version: 31-May-2017
Alternate Names:

ENSG00000049319 Gene Symbol

SRD5A2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Steroid 5-alpha-reductase 2
- Version: 2020.06.01
Alternate Names:

SRD5A2 TTD Gene Abbreviation

T71390 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Steroid 5-alpha-reductase inhibitor
Direct Interaction	yes
Trial Name	dutasteride + tamsulosin,Jalyn

Direct Interaction	yes
Mechanism of Interaction	Steroid 5-alpha-reductase 2 inhibitor
Trial Name	YM-152, finasteride

SRD5A2	GENE_SYMBOL
3-oxo-5-alpha-steroid 4-dehydrogenase 2	UNIPROT
5 alpha-SR2	UNIPROT

SRD5A2 Gene Record

SRD5A2 6716 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

DUTASTERIDE SRD5A2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Steroid 5-alpha-reductase inhibitor Direct Interaction yes Trial Name dutasteride + tamsulosin,Jalyn

PMIDs: 19707263 19543428 19879888 19091347 16818707 20426708 19200641 11752352 18318566

Sources: TdgClinicalTrial ChemblInteractions TEND

FINASTERIDE SRD5A2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Steroid 5-alpha-reductase 2 inhibitor Trial Name YM-152, finasteride

PMIDs: 12773767 19707263 19543428 12670724 20460827 16818707 16019620

Sources: TdgClinicalTrial ChemblInteractions TTD

Ensembl: ENSG00000277893

Alternate Names: SRD5A2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P31213

Alternate Names: S5A2_HUMAN Uniprot Id 6716 Entrez Gene Id SRD5A2 Gene Symbol

Gene Info: Target Subclass 1.3.99 Transmembrane Helix Count 7 Target Main Class Enzymes

Publications:

TdgClinicalTrial: P31213

Alternate Names: SRD5A2 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:1.3.99 Target Subclass EC:1.3.1.30

Publications:

ChemblInteractions: SRD5A2

Alternate Names: SRD5A2 GENE_SYMBOL 3-oxo-5-alpha-steroid 4-dehydrogenase 2 UNIPROT 5 alpha-SR2 UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000049319

Alternate Names: ENSG00000049319 Gene Symbol SRD5A2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Steroid 5-alpha-reductase 2

Alternate Names: SRD5A2 TTD Gene Abbreviation T71390 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Steroid 5-alpha-reductase inhibitor

Direct Interaction yes

Trial Name dutasteride + tamsulosin,Jalyn

PMIDs:
19707263 19543428 19879888 19091347 16818707 20426708 19200641 11752352 18318566

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Steroid 5-alpha-reductase 2 inhibitor

Trial Name YM-152, finasteride

PMIDs:
12773767 19707263 19543428 12670724 20460827 16818707 16019620

Sources:
TdgClinicalTrial ChemblInteractions TTD

Alternate Names:

SRD5A2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

S5A2_HUMAN Uniprot Id

6716 Entrez Gene Id

SRD5A2 Gene Symbol

Gene Info:

Target Subclass 1.3.99

Transmembrane Helix Count 7

Target Main Class Enzymes

Alternate Names:

SRD5A2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.3.99

Target Subclass EC:1.3.1.30

Alternate Names:

SRD5A2 GENE_SYMBOL

3-oxo-5-alpha-steroid 4-dehydrogenase 2 UNIPROT

5 alpha-SR2 UNIPROT

Alternate Names:

ENSG00000049319 Gene Symbol

SRD5A2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SRD5A2 TTD Gene Abbreviation

T71390 TTD Target ID