DGIdb - ILOPROST Drug Record

ILOPROST chembl:CHEMBL494 ApprovedAntineoplastic

Alternate Names:

CILOPROST
ZK-36374
ILOPROST
VENTAVIS
ZK-00036374
drugbank:01088
chembl:CHEMBL494
pubchem.compound:5311181
rxcui:40138
chemidplus:78919-13-8

Drug Info:

Year of Approval	2004
Drug Class	antihypertensive agents
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent

(2 More Sources)

Publications:

Walch et al., 2001, Prostanoid EP(1)- and TP-receptors involved in the contraction of human pulmonary veins., Br. J. Pharmacol.
Sharif et al., 2002, Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques., J. Pharm. Pharmacol.
Takamatsu et al., 2002, Specific ligand for a central type prostacyclin receptor attenuates neuronal damage in a rat model of focal cerebral ischemia., Brain Res.
Krug et al., 2009, Inhaled iloprost for the control of pulmonary hypertension., Vasc Health Risk Manag
Idzko et al., 2007, Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function., J. Clin. Invest.
Tsai et al., 1988, Interaction between platelet receptor and iloprost isomers., Biochim. Biophys. Acta
Anderson et al., Pharmacotherapeutic management of pulmonary arterial hypertension., Cardiol Rev
Schermuly et al., 2007, Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs., Respir. Res.
Crutchley et al., 1992, Prostacyclin analogues inhibit tissue factor expression in the human monocytic cell line THP-1 via a cyclic AMP-dependent mechanism., Arterioscler. Thromb.
Mubarak, 2010, A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension., Respir Med
Olschewski et al., 2004, Prostacyclin and its analogues in the treatment of pulmonary hypertension., Pharmacol. Ther.

ILOPROST PTGIR

Interaction Score: 15.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Prostanoid IP receptor agonist

Direct Interaction yes

Trial Name iloprost,Ventavis

PMIDs:
11792366 19475782 17273558 2456096 20395700 17257398 1375507 19683911 15163595

Sources:
TdgClinicalTrial ChemblInteractions TEND
ILOPROST PTGER1

Interaction Score: 6.87

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name iloprost,Ventavis

Novel drug target Established target

PMIDs:
11739243 11999132

Sources:
TdgClinicalTrial TEND
ILOPROST PTGER2

Interaction Score: 1.55

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
TTD
ILOPROST PPARA

Interaction Score: 0.27

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC

TEND: ILOPROST
- Version: 01-August-2011
Alternate Names:

ILOPROST Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 2004

Publications:
TdgClinicalTrial: ILOPROST
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:
TALC: ILOPROST
- Version: 12-May-2016
Alternate Names:

ILOPROST Primary Drug Name

ILOPROST Drug Generic Name

VENTAVIS Drug Trade Name

Drug Info:

Publications:
TTD: Iloprost
- Version: 2020.06.01
Alternate Names:

D05ZTH TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL494
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL494
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Prostanoid IP receptor agonist
Direct Interaction	yes
Trial Name	iloprost,Ventavis

Trial Name	iloprost,Ventavis
Novel drug target	Established target

ILOPROST	Primary Drug Name
ILOPROST	Drug Generic Name
VENTAVIS	Drug Trade Name

ILOPROST Drug Record

ILOPROST chembl:CHEMBL494 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

ILOPROST PTGIR

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Prostanoid IP receptor agonist Direct Interaction yes Trial Name iloprost,Ventavis

PMIDs: 11792366 19475782 17273558 2456096 20395700 17257398 1375507 19683911 15163595

Sources: TdgClinicalTrial ChemblInteractions TEND

ILOPROST PTGER1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name iloprost,Ventavis Novel drug target Established target

PMIDs: 11739243 11999132

Sources: TdgClinicalTrial TEND

ILOPROST PTGER2

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: None found

Sources: TTD

ILOPROST PPARA

Interaction Types & Directionality: activator (activating)

Interaction Info: Notes

PMIDs: None found

Sources: TALC

TEND: ILOPROST

Alternate Names: ILOPROST Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval 2004

Publications:

TdgClinicalTrial: ILOPROST

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval approved

Publications:

TALC: ILOPROST

Alternate Names: ILOPROST Primary Drug Name ILOPROST Drug Generic Name VENTAVIS Drug Trade Name

Drug Info:

Publications:

TTD: Iloprost

Alternate Names: D05ZTH TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL494

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL494

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Prostanoid IP receptor agonist

Direct Interaction yes

Trial Name iloprost,Ventavis

PMIDs:
11792366 19475782 17273558 2456096 20395700 17257398 1375507 19683911 15163595

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name iloprost,Ventavis

Novel drug target Established target

PMIDs:
11739243 11999132

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC

Alternate Names:

ILOPROST Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 2004

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

ILOPROST Primary Drug Name

ILOPROST Drug Generic Name

VENTAVIS Drug Trade Name

Alternate Names:

D05ZTH TTD Drug ID