DGIdb - LEVONORGESTREL Drug Record

LEVONORGESTREL chembl:CHEMBL1389 Approved

Alternate Names:

LILETTA
PLAN B
UPOSTELLE
LEVONELLE ONE STEP
LEVONELLE-2
ISTERANDA
JADELLE
PLAN B ONE-STEP
OPCICON ONE-STEP
LEVOSERT
ATHENTIA NEXT
MIRENA
NORPLANT
NORGESTREL (-)-FORM
WY-5104
NORGESTON
NORPLANT SYSTEM
POSTINOR-2
NORPLANT II
FALLBACK SOLO
KYLEENA
EZINELLE
BAY86-5028
HER STYLE
LEVONORGESTREL
OVRETTE
EMERRES UNA
JAYDESS
LEVONELLE
EMERRES
SKYLA
MICROVAL
(8R,9S,10R,13S,14S,17R)-13-ETHYL-17-ETHYNYL-17-HYDROXY- 1,2,6,7,8,9,10,11,12,13,14,15,16, 17- TETRADECAHYDROCYCLOPENTA[A] PHENANTHREN-3-ONE
17-ETHYNYL-18-METHYL-19-NORTESTOSTERONE
LÉVONORGESTREL
18-METHYL-17-ALPHA-ETHYNYL-19-NORTESTOSTERONE
18-METHYLNORETHISTERONE
WY-3707
(-)-13-ETHYL-17-HYDROXY-18,19-DINOR-17ALPHA-PREGN-4-EN-20-YN-3-ONE
13-BETA-ETHYL-17ALPHA-ETHYNYL-17BETA-HYDROXYGON-4-EN-3-ONE
MICROLUT
13-ETHYL-17-ALPHA-ETHYNYLGON-4-EN-17-BETA-OL-3-ONE
13-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXY-4-GONEN-3-ONE
17ALPHA-ETHYNYL-13BETA-ETHYL-3-OXO-4-ESTREN-17BETA-OL
LEVONORGESTRELUM
17ALPHA-ETHYNYL-17-HYDROXY-18-METHYLESTR-4-EN-3-ONE
POSTINOR
D(-)-NORGESTREL
LEVONOVA
NORLEVO
17ALPHA-ETHYNYL-18-HOMO-19-NORTESTOSTERONE
MICROLUTON
17-ALPHA-ETHINYL-13-BETA-ETHYL-17-BETA-HYDROXY-4-ESTREN-3-ONE
17-ALPHA-ETHYNYL-13-ETHYL-19-NORTESTOSTERONE
drugbank:00367
pubchem.compound:13109
chembl:CHEMBL1389
chemidplus:797-63-7
rxcui:6373

Drug Info:

Drug Indications	for treatment of menopausal symptoms
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	contraceptive
Drug Class	contraceptives
Year of Approval	approved before 1982

(1 More Sources)

Publications:

Bray et al., 2005, Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells., J. Steroid Biochem. Mol. Biol.
Hompes et al., 2007, Endometriosis: the way forward., Gynecol. Endocrinol.
Mirkin et al., 2005, Effect of 17 beta-estradiol, progesterone, synthetic progestins, tibolone, and tibolone metabolites on vascular endothelial growth factor mRNA in breast cancer cells., Fertil. Steril.
Maruo et al., 2007, Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas., Contraception
Creinin et al., 2006, Progesterone receptor modulator for emergency contraception: a randomized controlled trial., Obstet Gynecol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Hammond et al., 2001, Preclinical profiles of progestins used in formulations of oral contraceptives and hormone replacement therapy., Am. J. Obstet. Gynecol.
Rabe et al., 2000, Inhibition of skin 5 alpha-reductase by oral contraceptive progestins in vitro., Gynecol. Endocrinol.
Cassidenti DL et al., 1991, Effects of sex steroids on skin 5 alpha-reductase activity in vitro., Obstet Gynecol
Vijayanathan et al., 2006, Physiologic levels of 2-methoxyestradiol interfere with nongenomic signaling of 17beta-estradiol in human breast cancer cells., Clin. Cancer Res.
Vereide et al., 2006, Effect of levonorgestrel IUD and oral medroxyprogesterone acetate on glandular and stromal progesterone receptors (PRA and PRB), and estrogen receptors (ER-alpha and ER-beta) in human endometrial hyperplasia., Gynecol. Oncol.
Sun et al., 2007, Contribution of epoxyeicosatrienoic acids to flow-induced dilation in arteries of male ERalpha knockout mice: role of aromatase., Am. J. Physiol. Regul. Integr. Comp. Physiol.
Abdel-Aleem et al., 2005, Tamoxifen treatment of bleeding irregularities associated with Norplant use., Contraception
Lv XH et al., 2011, Effects of levonorgestrel on reproductive hormone levels and their receptor expression in Mongolian gerbils (Meriones unguiculatus)., Exp Anim
Lemus AE et al., 1992, Mechanism of action of levonorgestrel: in vitro metabolism and specific interactions with steroid receptors in target organs., J Steroid Biochem Mol Biol
García-Becerra R et al., 2002, The intrinsic transcriptional estrogenic activity of a non-phenolic derivative of levonorgestrel is mediated via the estrogen receptor-alpha., J Steroid Biochem Mol Biol

LEVONORGESTREL SRD5A1

Interaction Score: 16.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name AG-200-15

Novel drug target Established target

Trial Name estradol/levonorgestrel,Menostar

PMIDs:
11521119 11075290 1828548

Sources:
TdgClinicalTrial
LEVONORGESTREL PGR

Interaction Score: 4.04

Interaction Types & Directionality:

agonist (activating)

binder

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor agonist

Trial Name SOH-075,NorLevo

PMIDs:
16157482 17484506 16084894 17531625 17077229 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
LEVONORGESTREL ESR1

Interaction Score: 1.06

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name ethinyl estradiol + levonorgestrel,Seasonale, Lo Seasonale, Seasonique

Novel drug target Established target

Trial Name AG-200-15

PMIDs:
16609013 16084894 16325240 17634204 16307966 21791876 1562565 12589940

Sources:
TdgClinicalTrial TEND

TEND: LEVONORGESTREL
- Version: 01-August-2011
Alternate Names:

LEVONORGESTREL Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class contraceptives

Publications:
TdgClinicalTrial: LEVONORGESTREL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications contraceptive

Drug Class Small Molecule

FDA Approval approved

Publications:
TTD: Levonorgestrel
- Version: 2020.06.01
Alternate Names:

D0BA9U TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL1389
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1389
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	AG-200-15
Novel drug target	Established target
Trial Name	estradol/levonorgestrel,Menostar

Direct Interaction	yes
Mechanism of Interaction	Progesterone receptor agonist
Trial Name	SOH-075,NorLevo

Trial Name	ethinyl estradiol + levonorgestrel,Seasonale, Lo Seasonale, Seasonique
Novel drug target	Established target
Trial Name	AG-200-15

agonist (activating)
binder
modulator

LEVONORGESTREL Drug Record

LEVONORGESTREL chembl:CHEMBL1389 Approved

Alternate Names:

Drug Info:

Publications:

LEVONORGESTREL SRD5A1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name AG-200-15 Novel drug target Established target Trial Name estradol/levonorgestrel,Menostar

PMIDs: 11521119 11075290 1828548

Sources: TdgClinicalTrial

LEVONORGESTREL PGR

Interaction Types & Directionality: agonist (activating) binder modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Progesterone receptor agonist Trial Name SOH-075,NorLevo

PMIDs: 16157482 17484506 16084894 17531625 17077229 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

LEVONORGESTREL ESR1

Interaction Types & Directionality: other/unknown

Interaction Info: Trial Name ethinyl estradiol + levonorgestrel,Seasonale, Lo Seasonale, Seasonique Novel drug target Established target Trial Name AG-200-15

PMIDs: 16609013 16084894 16325240 17634204 16307966 21791876 1562565 12589940

Sources: TdgClinicalTrial TEND

TEND: LEVONORGESTREL

Alternate Names: LEVONORGESTREL Primary Drug Name

Drug Info: Year of Approval approved before 1982 Drug Class contraceptives

Publications:

TdgClinicalTrial: LEVONORGESTREL

Alternate Names:

Drug Info: Drug Indications contraceptive Drug Class Small Molecule FDA Approval approved

Publications:

TTD: Levonorgestrel

Alternate Names: D0BA9U TTD Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL1389

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1389

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name AG-200-15

Novel drug target Established target

Trial Name estradol/levonorgestrel,Menostar

PMIDs:
11521119 11075290 1828548

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

binder

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor agonist

Trial Name SOH-075,NorLevo

PMIDs:
16157482 17484506 16084894 17531625 17077229 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name ethinyl estradiol + levonorgestrel,Seasonale, Lo Seasonale, Seasonique

Novel drug target Established target

Trial Name AG-200-15

PMIDs:
16609013 16084894 16325240 17634204 16307966 21791876 1562565 12589940

Sources:
TdgClinicalTrial TEND

Alternate Names:

LEVONORGESTREL Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class contraceptives

Drug Info:

Drug Indications contraceptive

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D0BA9U TTD Drug ID