DGIdb - LISDEXAMFETAMINE Drug Record

LISDEXAMFETAMINE chembl:CHEMBL1201222 Approved

Alternate Names:

LISDEXAMFETAMINE
NRP104
VYVANSE®
ELVANSE
LISDEXAMFETAMINE DIMESYLATE
pubchem.compound:11597698
rxcui:700810
chemidplus:608137-32-2
chembl:CHEMBL1201222
drugbank:01255

Drug Info:

Year of Approval	2007
Drug Class	central nervous system stimulants
FDA Approval	2007
Drug Class	small molecule
Drug Indications	Central Nervous System Stimulants

(0 More Sources)

Publications:

Liu JF et al., 2018, TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg., Front Pharmacol
Pei Y et al., 2016, Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications., Front Neurosci
Miller GM, 2011, The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity., J Neurochem
Hamidovic et al., 2010, Polymorphisms in dopamine transporter (SLC6A3) are associated with stimulant effects of D-amphetamine: an exploratory pharmacogenetic study using healthy volunteers., Behav. Genet.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

LISDEXAMFETAMINE TAAR1

Interaction Score: 2.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
29636691 27092049 21073468

Sources:
TTD
LISDEXAMFETAMINE ADRA1B

Interaction Score: 1.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 11752352

Sources:
TdgClinicalTrial TEND
LISDEXAMFETAMINE SLC6A3

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
20091113

Sources:
TdgClinicalTrial TEND
LISDEXAMFETAMINE ADRA1A

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

TEND: LISDEXAMFETAMINE
- Version: 01-August-2011
Alternate Names:

LISDEXAMFETAMINE Primary Drug Name

Drug Info:

Drug Class central nervous system stimulants

Year of Approval 2007

Publications:
TdgClinicalTrial: LISDEXAMFETAMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Central Nervous System Stimulants

Drug Class small molecule

FDA Approval 2007

Publications:
TTD: Lisdexamfetamine
- Version: 2020.06.01
Alternate Names:

D00DEF TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201222
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

LISDEXAMFETAMINE Drug Record

LISDEXAMFETAMINE chembl:CHEMBL1201222 Approved

Alternate Names:

Drug Info:

Publications:

LISDEXAMFETAMINE TAAR1

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 29636691 27092049 21073468

Sources: TTD

LISDEXAMFETAMINE ADRA1B

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 11752352

Sources: TdgClinicalTrial TEND

LISDEXAMFETAMINE SLC6A3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 20091113

Sources: TdgClinicalTrial TEND

LISDEXAMFETAMINE ADRA1A

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

TEND: LISDEXAMFETAMINE

Alternate Names: LISDEXAMFETAMINE Primary Drug Name

Drug Info: Drug Class central nervous system stimulants Year of Approval 2007

Publications:

TdgClinicalTrial: LISDEXAMFETAMINE

Alternate Names:

Drug Info: Drug Indications Central Nervous System Stimulants Drug Class small molecule FDA Approval 2007

Publications:

TTD: Lisdexamfetamine

Alternate Names: D00DEF TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201222

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

PMIDs:
29636691 27092049 21073468

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
20091113

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Alternate Names:

LISDEXAMFETAMINE Primary Drug Name

Drug Info:

Drug Class central nervous system stimulants

Year of Approval 2007

Drug Info:

Drug Indications Central Nervous System Stimulants

Drug Class small molecule

FDA Approval 2007

Alternate Names:

D00DEF TTD Drug ID