DGIdb - LOFEXIDINE Drug Record

LOFEXIDINE chembl:CHEMBL17860 Approved

Alternate Names:

LOFEXIDINE
2-(ALPHA-(2,6-DICHLOROPHENOXY)ETHYL)2-IMIDAZOLINE
pubchem.compound:30668
drugbank:04948
rxcui:28863
chembl:CHEMBL17860
chemidplus:31036-80-3

Drug Info:

Drug Class	treatment for opiate withdrawal
Year of Approval	not approved by the fda
Drug Class	antihypertensive agents
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of opiate withdrawal

(2 More Sources)

Publications:

Erb et al., 2000, Alpha-2 adrenergic receptor agonists block stress-induced reinstatement of cocaine seeking., Neuropsychopharmacology
Strang et al., 1999, Lofexidine for opiate detoxification: review of recent randomised and open controlled trials., Am J Addict
Jin et al., 1992, Effects of lofexidine, an alpha 2-adrenoreceptor agonist, on ocular blood flow and ion transport of rabbit iris-ciliary body., J Ocul Pharmacol

LOFEXIDINE ADRA2A

Interaction Score: 1.31

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name lofexidine,BritLofex

Novel drug target Established target

PMIDs:
10882840 10598217 1357064

Sources:
TdgClinicalTrial TEND TTD
LOFEXIDINE ADRA2B

Interaction Score: 0.63

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name lofexidine,BritLofex

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
LOFEXIDINE ADRA2C

Interaction Score: 0.5

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name lofexidine,BritLofex

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
LOFEXIDINE CYP2D6

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA

TEND: LOFEXIDINE
- Version: 01-August-2011
Alternate Names:

LOFEXIDINE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval not approved by the fda

Drug Class treatment for opiate withdrawal

Publications:
TdgClinicalTrial: LOFEXIDINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of opiate withdrawal

Drug Class Small Molecule

FDA Approval approved

Publications:
TTD: Lofexidine
- Version: 2020.06.01
Alternate Names:

D0K0MW TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL17860
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Lofexidine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
PharmGKB: lofexidine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	lofexidine,BritLofex
Novel drug target	Established target

LOFEXIDINE Drug Record

LOFEXIDINE chembl:CHEMBL17860 Approved

Alternate Names:

Drug Info:

Publications:

LOFEXIDINE ADRA2A

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name lofexidine,BritLofex Novel drug target Established target

PMIDs: 10882840 10598217 1357064

Sources: TdgClinicalTrial TEND TTD

LOFEXIDINE ADRA2B

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name lofexidine,BritLofex Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

LOFEXIDINE ADRA2C

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name lofexidine,BritLofex

PMIDs: None found

Sources: TdgClinicalTrial TEND

LOFEXIDINE CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

TEND: LOFEXIDINE

Alternate Names: LOFEXIDINE Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval not approved by the fda Drug Class treatment for opiate withdrawal

Publications:

TdgClinicalTrial: LOFEXIDINE

Alternate Names:

Drug Info: Drug Indications for treatment of opiate withdrawal Drug Class Small Molecule FDA Approval approved

Publications:

TTD: Lofexidine

Alternate Names: D0K0MW TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL17860

Alternate Names:

Drug Info:

Publications:

FDA: Lofexidine

Alternate Names:

Drug Info:

Publications:

PharmGKB: lofexidine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name lofexidine,BritLofex

Novel drug target Established target

PMIDs:
10882840 10598217 1357064

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name lofexidine,BritLofex

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name lofexidine,BritLofex

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Alternate Names:

LOFEXIDINE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval not approved by the fda

Drug Class treatment for opiate withdrawal

Drug Info:

Drug Indications for treatment of opiate withdrawal

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D0K0MW TTD Drug ID