DGIdb - MUROMONAB-CD3 Drug Record

MUROMONAB-CD3 chembl:CHEMBL1201608 ApprovedImmunotherapy

Alternate Names:

OKT-3
OKT3
ORTHOCLONE OKT3
L04AA02
MUROMONAB-CD3
MUROMONAB CD3
ANTI-CD3
ORTHOCLONE OKT3®
drugbank:00075
chemidplus:140608-64-6
chembl:CHEMBL1201608

Drug Info:

Drug Class	immunosuppressive agents
Year of Approval	1986
FDA Approval	1986
Drug Class	monoclonal antibody
Drug Indications	Immunosuppressive Agents

(1 More Sources)

Publications:

Wilde et al., 1996, Muromonab CD3: a reappraisal of its pharmacology and use as prophylaxis of solid organ transplant rejection., Drugs
Todd et al., 1989, Muromonab CD3. A review of its pharmacology and therapeutic potential., Drugs
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

MUROMONAB-CD3 CD247

Interaction Score: 15.46

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8861551 2503348

Sources:
TdgClinicalTrial
MUROMONAB-CD3 CD3E

Interaction Score: 10.82

Interaction Types & Directionality:

antibody (inhibitory)

binder

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction T cell surface glycoprotein CD3 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
MUROMONAB-CD3 CD3D

Interaction Score: 8.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction T cell surface glycoprotein CD3 inhibitor

PMIDs:
8861551 2503348

Sources:
TdgClinicalTrial ChemblInteractions
MUROMONAB-CD3 CD3G

Interaction Score: 4.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction T cell surface glycoprotein CD3 inhibitor

PMIDs:
8861551 2503348

Sources:
TdgClinicalTrial ChemblInteractions

TEND: MUROMONAB
- Version: 01-August-2011
Alternate Names:

MUROMONAB Primary Drug Name

Drug Info:

Year of Approval 1986

Drug Class immunosuppressive agents

Publications:
TdgClinicalTrial: MUROMONAB
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Immunosuppressive Agents

Drug Class monoclonal antibody

FDA Approval 1986

Publications:
TTD: Muromonab
- Version: 2020.06.01
Alternate Names:

D0C6PS TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL1201608
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201608
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	T cell surface glycoprotein CD3 inhibitor
Direct Interaction	yes
Trial Name	-

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	T cell surface glycoprotein CD3 inhibitor

antibody (inhibitory)
binder
inhibitor (inhibitory)

MUROMONAB-CD3 Drug Record

MUROMONAB-CD3 chembl:CHEMBL1201608 ApprovedImmunotherapy

Alternate Names:

Drug Info:

Publications:

MUROMONAB-CD3 CD247

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8861551 2503348

Sources: TdgClinicalTrial

MUROMONAB-CD3 CD3E

Interaction Types & Directionality: antibody (inhibitory) binder inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction T cell surface glycoprotein CD3 inhibitor Direct Interaction yes Trial Name -

PMIDs: 17016423 17139284 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

MUROMONAB-CD3 CD3D

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction T cell surface glycoprotein CD3 inhibitor

PMIDs: 8861551 2503348

Sources: TdgClinicalTrial ChemblInteractions

MUROMONAB-CD3 CD3G

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction T cell surface glycoprotein CD3 inhibitor

PMIDs: 8861551 2503348

Sources: TdgClinicalTrial ChemblInteractions

TEND: MUROMONAB

Alternate Names: MUROMONAB Primary Drug Name

Drug Info: Year of Approval 1986 Drug Class immunosuppressive agents

Publications:

TdgClinicalTrial: MUROMONAB

Alternate Names:

Drug Info: Drug Indications Immunosuppressive Agents Drug Class monoclonal antibody FDA Approval 1986

Publications:

TTD: Muromonab

Alternate Names: D0C6PS TTD Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL1201608

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201608

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8861551 2503348

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antibody (inhibitory)

binder

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction T cell surface glycoprotein CD3 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction T cell surface glycoprotein CD3 inhibitor

PMIDs:
8861551 2503348

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction T cell surface glycoprotein CD3 inhibitor

PMIDs:
8861551 2503348

Sources:
TdgClinicalTrial ChemblInteractions

Alternate Names:

MUROMONAB Primary Drug Name

Drug Info:

Year of Approval 1986

Drug Class immunosuppressive agents

Drug Info:

Drug Indications Immunosuppressive Agents

Drug Class monoclonal antibody

FDA Approval 1986

Alternate Names:

D0C6PS TTD Drug ID