DGIdb - PHYSOSTIGMINE Drug Record

PHYSOSTIGMINE chembl:CHEMBL94 Approved

Alternate Names:

NSC-30782
ESERINE
PHYSOSTIGMINE
MCV-4484
ANTILIRIUM
PHYSOSTOL
ANTILIRIUM®
PHYSOSTIGMINE SALICYLATE
pubchem.compound:5983
chemidplus:57-47-6
rxcui:8299
chembl:CHEMBL94
drugbank:00981

Drug Info:

Year of Approval	approved before 1982
Drug Class	miotics
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of dry mouth

(0 More Sources)

Publications:

Monnet-Tschudi et al., 2000, Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures., Toxicol. Appl. Pharmacol.
Nguyen et al., 1999, Maturation of neuromuscular transmission during early development in zebrafish., J. Neurophysiol.
Tuovinen et al., 1999, Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication., Toxicology
Blasina et al., 2000, Evidence for a noncholinergic function of acetylcholinesterase during development of chicken retina as shown by fasciculin., Cell Tissue Res.
Bolognesi et al., 2001, Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors., J. Med. Chem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

PHYSOSTIGMINE ACHE

Interaction Score: 4.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name physostigmine ,Xalieve

PMIDs:
10873710 10368402 10403635 10741458 11141093 11752352

Sources:
TdgClinicalTrial TEND
PHYSOSTIGMINE ALDH1A1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHYSOSTIGMINE EHMT2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PHYSOSTIGMINE
- Version: 01-August-2011
Alternate Names:

PHYSOSTIGMINE Primary Drug Name

Drug Info:

Drug Class miotics

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: PHYSOSTIGMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of dry mouth

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: PHYSOSTIGMINE
- Version: 02-September-2020
Alternate Names:

CHEMBL94 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL94
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

PHYSOSTIGMINE Drug Record

PHYSOSTIGMINE chembl:CHEMBL94 Approved

Alternate Names:

Drug Info:

Publications:

PHYSOSTIGMINE ACHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name physostigmine ,Xalieve

PMIDs:
10873710 10368402 10403635 10741458 11141093 11752352

Sources:
TdgClinicalTrial TEND

PHYSOSTIGMINE ALDH1A1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

PHYSOSTIGMINE EHMT2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PHYSOSTIGMINE

Alternate Names:

PHYSOSTIGMINE Primary Drug Name

Drug Info:

Drug Class miotics

Year of Approval approved before 1982

Publications:

TdgClinicalTrial: PHYSOSTIGMINE

Alternate Names:

Drug Info:

Drug Indications for treatment of dry mouth

Drug Class Small Molecule

FDA Approval approved

Publications:

DTC: PHYSOSTIGMINE

Alternate Names:

CHEMBL94 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL94

Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	physostigmine ,Xalieve

PHYSOSTIGMINE Drug Record

PHYSOSTIGMINE chembl:CHEMBL94 Approved

Alternate Names:

Drug Info:

Publications:

PHYSOSTIGMINE ACHE

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name physostigmine ,Xalieve

PMIDs: 10873710 10368402 10403635 10741458 11141093 11752352

Sources: TdgClinicalTrial TEND

PHYSOSTIGMINE ALDH1A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

PHYSOSTIGMINE EHMT2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: PHYSOSTIGMINE

Alternate Names: PHYSOSTIGMINE Primary Drug Name

Drug Info: Drug Class miotics Year of Approval approved before 1982

Publications:

TdgClinicalTrial: PHYSOSTIGMINE

Alternate Names:

Drug Info: Drug Indications for treatment of dry mouth Drug Class Small Molecule FDA Approval approved

Publications:

DTC: PHYSOSTIGMINE

Alternate Names: CHEMBL94 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL94

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name physostigmine ,Xalieve

PMIDs:
10873710 10368402 10403635 10741458 11141093 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PHYSOSTIGMINE Primary Drug Name

Drug Info:

Drug Class miotics

Year of Approval approved before 1982

Drug Info:

Drug Indications for treatment of dry mouth

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL94 ChEMBL Drug ID