DGIdb - PRAMLINTIDE Drug Record

PRAMLINTIDE chembl:CHEMBL2103758 ApprovedAntineoplastic

Alternate Names:

AC137
AC-137
AC-0137
PRAMLINTIDE
AC0137
TRIPRO-AMYLIN
chemidplus:151126-32-8
rxcui:139953
drugbank:01278
pubchem.compound:70691388
chembl:CHEMBL2103758

Drug Info:

Drug Class	hypoglycemic agents
Year of Approval	2005
FDA Approval	approved
Drug Class	peptide
Drug Indications	antidiabetic,antiobesity agent

(0 More Sources)

Publications:

Qi et al., 2010, Structure-function relationships of the N-terminus of receptor activity-modifying proteins., Br. J. Pharmacol.
Nyholm et al., 2001, Amylin receptor agonists: a novel pharmacological approach in the management of insulin-treated diabetes mellitus., Expert Opin Investig Drugs
Qi et al., 2008, Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function., Mol. Pharmacol.
Hay et al., 2004, Amylin receptors: molecular composition and pharmacology., Biochem. Soc. Trans.
Lutz, 2010, The role of amylin in the control of energy homeostasis., Am. J. Physiol. Regul. Integr. Comp. Physiol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Roth et al., 2009, Implications of amylin receptor agonism: integrated neurohormonal mechanisms and therapeutic applications., Arch. Neurol.

PRAMLINTIDE RAMP2

Interaction Score: 49.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Symlin

Novel drug target Established target

PMIDs:
20015292 18593822 15494035 17016423 17139284 19273748

Sources:
TdgClinicalTrial TEND
PRAMLINTIDE RAMP1

Interaction Score: 41.22

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Symlin

Novel drug target Established target

PMIDs:
20015292 11772274 18593822 15494035 20357016 17016423 17139284 19273748

Sources:
TdgClinicalTrial TEND
PRAMLINTIDE RAMP3

Interaction Score: 41.22

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name Symlin

PMIDs:
20015292 11772274 18593822 15494035 20357016 17016423 17139284 19273748

Sources:
TdgClinicalTrial TEND
PRAMLINTIDE CALCR

Interaction Score: 10.82

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Symlin

Novel drug target Established target

PMIDs:
20015292 11772274 18593822 15494035 20357016 19273748

Sources:
TdgClinicalTrial
PRAMLINTIDE GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

TEND: PRAMLINTIDE
- Version: 01-August-2011
Alternate Names:

PRAMLINTIDE Primary Drug Name

Drug Info:

Year of Approval 2005

Drug Class hypoglycemic agents

Publications:
TdgClinicalTrial: PRAMLINTIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antidiabetic,antiobesity agent

Drug Class peptide

FDA Approval approved

Publications:
TTD: Pramlintide
- Version: 2020.06.01
Alternate Names:

D0C4AM TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL2103758
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	Symlin
Novel drug target	Established target

Trial Name	Symlin
Novel drug target	Established target

Novel drug target	Established target
Trial Name	Symlin

Trial Name	Symlin
Novel drug target	Established target

PRAMLINTIDE Drug Record

PRAMLINTIDE chembl:CHEMBL2103758 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

PRAMLINTIDE RAMP2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Symlin Novel drug target Established target

PMIDs: 20015292 18593822 15494035 17016423 17139284 19273748

Sources: TdgClinicalTrial TEND

PRAMLINTIDE RAMP1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Symlin Novel drug target Established target

PMIDs: 20015292 11772274 18593822 15494035 20357016 17016423 17139284 19273748

Sources: TdgClinicalTrial TEND

PRAMLINTIDE RAMP3

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name Symlin

PMIDs: 20015292 11772274 18593822 15494035 20357016 17016423 17139284 19273748

Sources: TdgClinicalTrial TEND

PRAMLINTIDE CALCR

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Symlin Novel drug target Established target

PMIDs: 20015292 11772274 18593822 15494035 20357016 19273748

Sources: TdgClinicalTrial

PRAMLINTIDE GLP1R

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TEND: PRAMLINTIDE

Alternate Names: PRAMLINTIDE Primary Drug Name

Drug Info: Year of Approval 2005 Drug Class hypoglycemic agents

Publications:

TdgClinicalTrial: PRAMLINTIDE

Alternate Names:

Drug Info: Drug Indications antidiabetic,antiobesity agent Drug Class peptide FDA Approval approved

Publications:

TTD: Pramlintide

Alternate Names: D0C4AM TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL2103758

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Symlin

Novel drug target Established target

PMIDs:
20015292 18593822 15494035 17016423 17139284 19273748

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Symlin

Novel drug target Established target

PMIDs:
20015292 11772274 18593822 15494035 20357016 17016423 17139284 19273748

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name Symlin

PMIDs:
20015292 11772274 18593822 15494035 20357016 17016423 17139284 19273748

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Symlin

Novel drug target Established target

PMIDs:
20015292 11772274 18593822 15494035 20357016 19273748

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

PRAMLINTIDE Primary Drug Name

Drug Info:

Year of Approval 2005

Drug Class hypoglycemic agents

Drug Info:

Drug Indications antidiabetic,antiobesity agent

Drug Class peptide

FDA Approval approved

Alternate Names:

D0C4AM TTD Drug ID