DGIdb - PSEUDOEPHEDRINE Drug Record

PSEUDOEPHEDRINE chembl:CHEMBL1590 Approved

Alternate Names:

PSEUDOEPHEDRINE
PSEUDOEPHEDRINE D-FORM
PSI-EPHEDRINE
(+)-PSEUDOEPHEDRINE
PSEUDOPHEDRINE SULPHATE
(+)-THREO-EPHEDRINE
D-ISOEPHEDRINE
ISOEPHEDRINE
D-PSI-2-METHYLAMINO-1-PHENYL-1-PROPANOL
(+) THREO-2-(METHYLAMINO)-1-PHENYL-1-PROPANOL
Ψ-EPHEDRINE
(+)-(1S,2S)-PSEUDOEPHEDRINE
(1S,2S)-PSEUDOEPHEDRINE
SUDAFED®
PSI-EPHEDRIN
(1S,2S)-(+)-PSEUDOEPHEDRINE
(+)-PSI-EPHEDRINE
PSEUDOEPHEDRINE HYDROCHLORIDE
PSEUDOEFEDRINA
2-(METHYLAMINO)-1-PHENYL-1-PROPANOL
PSEUDOEPHEDRINUM
L-(+)-PSEUDOEPHEDRINE
D-PSI-EPHEDRINE
D-PSEUDOEPHEDRINE BASE
PSEUDOÉPHÉDRINE
SINUTAB®
D-PSEUDOEPHEDRINE
L(+)-PSI-EPHEDRINE
TRANS-EPHEDRINE
drugbank:00852
chembl:CHEMBL1590
chemidplus:90-82-4
pubchem.compound:7028
rxcui:8896

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiallergy agent
Year of Approval	approved before 1982
Drug Class	vasoconstrictor agents
Drug Class	bronchodilator agents
Drug Class	nasal decongestants

(1 More Sources)

Publications:

Wee et al., 2004, Reinforcing effect of pseudoephedrine isomers and the mechanism of action., Eur. J. Pharmacol.
Foley et al., 2002, Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers., J Neural Transm (Vienna)
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Johnson DA et al., 1993, The pharmacology of alpha-adrenergic decongestants., Pharmacotherapy
Wellington et al., 2001, Cetirizine/pseudoephedrine., Drugs
Vansal et al., 1999, Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes., Biochem. Pharmacol.

PSEUDOEPHEDRINE GLA

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PSEUDOEPHEDRINE SLC6A2

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name fexofenadine + ps/

Novel drug target Established target

PMIDs:
15189772 12373557

Sources:
TdgClinicalTrial
PSEUDOEPHEDRINE ADRA2A

Interaction Score: 0.26

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name fexofenadine + ps/

Novel drug target Established target

PMIDs:
17016423 17139284 7507588

Sources:
TdgClinicalTrial TEND
PSEUDOEPHEDRINE ADRA1A

Interaction Score: 0.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name fexofenadine + ps/

Novel drug target Established target

PMIDs:
11772135 17016423 17139284 7507588

Sources:
TdgClinicalTrial TEND
PSEUDOEPHEDRINE SLC6A3

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name fexofenadine + ps/

Novel drug target Established target

PMIDs:
15189772 12373557

Sources:
TdgClinicalTrial
PSEUDOEPHEDRINE SLC6A4

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name fexofenadine + ps/

Novel drug target Established target

PMIDs:
15189772

Sources:
TdgClinicalTrial
PSEUDOEPHEDRINE ADRB2

Interaction Score: 0.11

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
10449190 17016423 17139284

Sources:
TEND
PSEUDOEPHEDRINE PKM

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PSEUDOEPHEDRINE ALOX15B

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PSEUDOEPHEDRINE THPO

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PSEUDOEPHEDRINE ALOX15

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PSEUDOEPHEDRINE DRD2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PSEUDOEPHEDRINE HSD17B10

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PSEUDOEPHEDRINE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PSEUDOEPHEDRINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PSEUDOEPHEDRINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PSEUDOEPHEDRINE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TdgClinicalTrial: PSEUDOEPHEDRINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiallergy agent

Drug Class Small Molecule

FDA Approval approved

Publications:
TEND: PSEUDOEPHEDRINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class nasal decongestants

Drug Class bronchodilator agents

Drug Class vasoconstrictor agents

Publications:
DTC: PSEUDOEPHEDRINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1590 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Pseudoephedrine
- Version: 2020.06.01
Alternate Names:

D00HHS TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1590
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	fexofenadine + ps/
Novel drug target	Established target

PSEUDOEPHEDRINE Drug Record

PSEUDOEPHEDRINE chembl:CHEMBL1590 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name fexofenadine + ps/ Novel drug target Established target

PMIDs: 15189772 12373557

Sources: TdgClinicalTrial

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name fexofenadine + ps/ Novel drug target Established target

PMIDs: 17016423 17139284 7507588

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name fexofenadine + ps/ Novel drug target Established target

PMIDs: 11772135 17016423 17139284 7507588

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name fexofenadine + ps/ Novel drug target Established target

PMIDs: 15189772 12373557

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name fexofenadine + ps/ Novel drug target Established target

PMIDs: 15189772

Sources: TdgClinicalTrial

Interaction Types & Directionality: partial agonist (activating)

Interaction Info:

PMIDs: 10449190 17016423 17139284

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TdgClinicalTrial: PSEUDOEPHEDRINE

Alternate Names:

Drug Info: Drug Indications antiallergy agent Drug Class Small Molecule FDA Approval approved

Publications:

TEND: PSEUDOEPHEDRINE

Alternate Names:

Drug Info: Drug Class nasal decongestants Drug Class bronchodilator agents Drug Class vasoconstrictor agents

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name fexofenadine + ps/

Novel drug target Established target

PMIDs:
15189772 12373557

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name fexofenadine + ps/

Novel drug target Established target

PMIDs:
17016423 17139284 7507588

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name fexofenadine + ps/

Novel drug target Established target

PMIDs:
11772135 17016423 17139284 7507588

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name fexofenadine + ps/

Novel drug target Established target

PMIDs:
15189772 12373557

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name fexofenadine + ps/

Novel drug target Established target

PMIDs:
15189772

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

partial agonist (activating)

PMIDs:
10449190 17016423 17139284

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Drug Info:

Drug Indications antiallergy agent

Drug Class Small Molecule

FDA Approval approved

Drug Info:

Drug Class nasal decongestants

Drug Class bronchodilator agents

Drug Class vasoconstrictor agents

Alternate Names:

CHEMBL1590 ChEMBL Drug ID

Alternate Names:

D00HHS TTD Drug ID