DGIdb - ROPINIROLE Drug Record

ROPINIROLE chembl:CHEMBL589 Approved

Alternate Names:

REQUIP
SK&F-101468
ROPINIROLE
SK&F-101468-A
REQUIP®
ROPINIROLUM
ROPINIROL
SK&F-101468A
drugbank:00268
chembl:CHEMBL589
rxcui:72302
chemidplus:91374-21-9
pubchem.compound:5095

Drug Info:

Year of Approval	1997
Drug Class	antiparkinson agents
FDA Approval	not approved
Drug Class	Small Molecule
Drug Indications	for treatment of restlegs legs syndrome
FDA Approval	approved
Drug Indications	antiparkinson agent

(3 More Sources)

Publications:

Rascol O et al., 2007, Dopamine agonists., Handb Clin Neurol
de Mey et al., 1991, Interactions between domperidone and ropinirole, a novel dopamine D2-receptor agonist., Br J Clin Pharmacol
Iida et al., 1999, Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist., Brain Res.
Matsukawa et al., 2007, Overexpression of D2/D3 receptors increases efficacy of ropinirole in chronically 6-OHDA-lesioned Parkinsonian rats., Brain Res.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
Lam, 2000, Clinical pharmacology of dopamine agonists., Pharmacotherapy
Shill HA et al., 2009, Update on ropinirole in the treatment of Parkinson's disease., Neuropsychiatr Dis Treat
Nashatizadeh MM et al., 2009, A review of ropinirole prolonged release in Parkinson's disease., Clin Interv Aging

ROPINIROLE DRD3

Interaction Score: 1.9

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name ReQuip

Novel drug target Established target

Trial Name JZP-7

PMIDs:
18691132 10641988 11752352 19557097 19503779

Sources:
TdgClinicalTrial TEND TTD
ROPINIROLE DRD4

Interaction Score: 1.47

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name JZP-7

Novel drug target Established target

PMIDs:
18691132 11752352 19557097

Sources:
TdgClinicalTrial
ROPINIROLE DRD2

Interaction Score: 1.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name JZP-7

Novel drug target Established target

Trial Name ReQuip

PMIDs:
18808942 1683559 10446316 17573046 11752352 18691132 10641988 19557097

Sources:
TdgClinicalTrial TEND PharmGKB TTD
ROPINIROLE CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: ROPINIROLE
- Version: 01-August-2011
Alternate Names:

ROPINIROLE Primary Drug Name

Drug Info:

Drug Class antiparkinson agents

Year of Approval 1997

Publications:
TdgClinicalTrial: ROPINIROL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiparkinson agent

Drug Class small molecule

FDA Approval approved

Publications:
TdgClinicalTrial: ROPINIROLE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of restlegs legs syndrome

Drug Class Small Molecule

FDA Approval not approved

Publications:
PharmGKB: ropinirole
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rascol O et al., 2007, Dopamine agonists., Handb Clin Neurol
TTD: Ropinirole
- Version: 2020.06.01
Alternate Names:

D0R9EQ TTD Drug ID

Drug Info:

Publications:
DTC: ROPINIROLE
- Version: 02-September-2020
Alternate Names:

CHEMBL589 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL589
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	ReQuip
Novel drug target	Established target
Trial Name	JZP-7

ROPINIROLE Drug Record

ROPINIROLE chembl:CHEMBL589 Approved

Alternate Names:

Drug Info:

Publications:

ROPINIROLE DRD3

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name ReQuip Novel drug target Established target Trial Name JZP-7

PMIDs: 18691132 10641988 11752352 19557097 19503779

Sources: TdgClinicalTrial TEND TTD

ROPINIROLE DRD4

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name JZP-7 Novel drug target Established target

PMIDs: 18691132 11752352 19557097

Sources: TdgClinicalTrial

ROPINIROLE DRD2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name JZP-7 Novel drug target Established target Trial Name ReQuip

PMIDs: 18808942 1683559 10446316 17573046 11752352 18691132 10641988 19557097

Sources: TdgClinicalTrial TEND PharmGKB TTD

ROPINIROLE CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: ROPINIROLE

Alternate Names: ROPINIROLE Primary Drug Name

Drug Info: Drug Class antiparkinson agents Year of Approval 1997

Publications:

TdgClinicalTrial: ROPINIROL

Alternate Names:

Drug Info: Drug Indications antiparkinson agent Drug Class small molecule FDA Approval approved

Publications:

TdgClinicalTrial: ROPINIROLE

Alternate Names:

Drug Info: Drug Indications for treatment of restlegs legs syndrome Drug Class Small Molecule FDA Approval not approved

Publications:

PharmGKB: ropinirole

Alternate Names:

Drug Info:

Publications: Rascol O et al., 2007, Dopamine agonists., Handb Clin Neurol

TTD: Ropinirole

Alternate Names: D0R9EQ TTD Drug ID

Drug Info:

Publications:

DTC: ROPINIROLE

Alternate Names: CHEMBL589 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL589

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name ReQuip

Novel drug target Established target

Trial Name JZP-7

PMIDs:
18691132 10641988 11752352 19557097 19503779

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name JZP-7

Novel drug target Established target

PMIDs:
18691132 11752352 19557097

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name JZP-7

Novel drug target Established target

Trial Name ReQuip

PMIDs:
18808942 1683559 10446316 17573046 11752352 18691132 10641988 19557097

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

ROPINIROLE Primary Drug Name

Drug Info:

Drug Class antiparkinson agents

Year of Approval 1997

Drug Info:

Drug Indications antiparkinson agent

Drug Class small molecule

FDA Approval approved

Drug Info:

Drug Indications for treatment of restlegs legs syndrome

Drug Class Small Molecule

FDA Approval not approved

Publications:

Rascol O et al., 2007, Dopamine agonists., Handb Clin Neurol

Alternate Names:

D0R9EQ TTD Drug ID

Alternate Names:

CHEMBL589 ChEMBL Drug ID