DGIdb - SEMAXANIB Drug Record

SEMAXANIB chembl:CHEMBL276711 Antineoplastic

Alternate Names:

SU005416
SEMAXINIB
SEMAXANIB
SU-5416
NSC-696819
SU 5416
3-(1-(3,5-DIMETHYL-1H-PYRROL-2-YL)METH-(Z)-YLIDENE)-2-OXO-2,3-DIHYDROINDOLE
(Z)-SU 5416
VEGF RECEPTOR 2 KINASE INHIBITOR III
SU5416
3-[(2,4-DIMETHYLPYRROL-5-YL)METHYLIDENYL]-2-INDOLINONE
TSU 16
3-((Z)-(3,5-DIMETHYLPYRROL-2-YL)METHYLENE)-2-INDOLINONE
chemidplus:194413-58-6
pubchem.compound:5329098
drugbank:06436
chembl:CHEMBL276711

Drug Info:

(0 More Sources)

Publications:

Mita MM et al., 2007, A phase II, pharmacokinetic, and biologic study of semaxanib and thalidomide in patients with metastatic melanoma., Cancer Chemother Pharmacol
Fury MG et al., 2007, A Phase II study of SU5416 in patients with advanced or recurrent head and neck cancers., Invest New Drugs
Hoff PM et al., 2006, A Phase I study of escalating doses of the tyrosine kinase inhibitor semaxanib (SU5416) in combination with irinotecan in patients with advanced colorectal carcinoma., Jpn J Clin Oncol
O'Farrell et al., 2004, Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia., Leuk. Res.

SEMAXANIB KDR

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
16736151 16983506 16449240

Sources:
ChemblInteractions
SEMAXANIB APOBEC3F

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SEMAXANIB FLT3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15158089

Sources:
NCI
SEMAXANIB APOBEC3G

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SEMAXANIB KIT

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Stem cell growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
SEMAXANIB FLT1

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SEMAXANIB FLT4

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SEMAXANIB MPHOSPH8

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SEMAXANIB DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SEMAXANIB USP1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SEMAXANIB YES1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SEMAXANIB KCNH2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SEMAXANIB MAPT

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SEMAXANIB EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: SU5416

Version: 14-September-2017

Alternate Names:

C1831 NCI drug code

Drug Info:

Publications:

O'Farrell et al., 2004, Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia., Leuk. Res.

DTC: SEMAXANIB
- Version: 02-September-2020
Alternate Names:

CHEMBL276711 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL276711
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL276711
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Vascular endothelial growth factor receptor inhibitor
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Stem cell growth factor receptor inhibitor

SEMAXANIB Drug Record

SEMAXANIB chembl:CHEMBL276711 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: 16736151 16983506 16449240

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15158089

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Stem cell growth factor receptor inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

NCI: SU5416

Alternate Names: C1831 NCI drug code

Drug Info:

Publications: O'Farrell et al., 2004, Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia., Leuk. Res.

DTC: SEMAXANIB

Alternate Names: CHEMBL276711 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL276711

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL276711

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
16736151 16983506 16449240

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15158089

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Stem cell growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

C1831 NCI drug code

Publications:

O'Farrell et al., 2004, Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia., Leuk. Res.

Alternate Names:

CHEMBL276711 ChEMBL Drug ID