DGIdb - T091317 Drug Record

T091317 chembl:CHEMBL62136

Alternate Names:

T0901317

Drug Info:

(0 More Sources)

Publications:

Hu B et al., 2010, Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist., J Med Chem
Høgmoen Åstrand OA et al., 2014, Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models., Eur J Med Chem
Hoang MH et al., 2012, Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells., Bioorg Med Chem Lett
Strand OA et al., 2014, Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol., Bioorg Med Chem
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Chao EY et al., 2008, Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity., J Med Chem

T091317 NR1H2

Interaction Score: 2.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
18800767 22579484 24480357 24268541 10592235

Sources:
DTC
T091317 RORA

Interaction Score: 1.72

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
DTC
T091317 NR1H3

Interaction Score: 1.52

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
24480357 22579484 24268541 10592235

Sources:
DTC
T091317 PPARA

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20350005

Sources:
DTC
T091317 NR1H4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
T091317 RXRA

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
T091317 RORC

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
DTC
T091317 TARDBP

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
T091317 NR3C1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
T091317 ATXN2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
T091317 NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
T091317 AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DTC: T091317

Version: 02-September-2020

Alternate Names:

CHEMBL62136 ChEMBL Drug ID

Drug Info:

Publications:

Hoang MH et al., 2012, Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells., Bioorg Med Chem Lett

Høgmoen Åstrand OA et al., 2014, Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models., Eur J Med Chem

Strand OA et al., 2014, Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol., Bioorg Med Chem

ChemblDrugs: chembl:CHEMBL62136
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

T091317 Drug Record

T091317 chembl:CHEMBL62136

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 18800767 22579484 24480357 24268541 10592235

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 24480357 22579484 24268541 10592235

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20350005

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DTC: T091317

Alternate Names: CHEMBL62136 ChEMBL Drug ID

Drug Info:

ChemblDrugs: chembl:CHEMBL62136

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

PMIDs:
18800767 22579484 24480357 24268541 10592235

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

PMIDs:
24480357 22579484 24268541 10592235

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20350005

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CHEMBL62136 ChEMBL Drug ID