DGIdb - TELMISARTAN Drug Record

TELMISARTAN chembl:CHEMBL1017 Approved

Alternate Names:

TOLURA
BIBR-277
MICARDIS
BIBR-277-SE
BIBR-277 SE
BIBR-277SE
TELMISARTAN
C09CA07
4'-((4-METHYL-6-(1-METHYL-2-BENZIMIDAZOLYL)-2-PROPYL-1-BENZIMIDAZOLYL)METHYL)-2-BIPHENYLCARBOXYLIC ACID
4'-((1,4'-DIMETHYL-2'-PROPYL(2,6'-BI-1H-BENZIMIDAZOL)-1'-YL)METHYL)-(1,1'-BIPHENYL)-2-CARBOXYLIC ACID
PRITOR®
4'-[(1,7'-DIMETHYL-2'-PROPYL-1H,3'H-2,5'-BIBENZIMIDAZOL-3'-YL)METHYL]BIPHENYL-2-CARBOXYLIC ACID
4'-[(1,4'-DIMETHYL-2'PROPYL[2,6'-BI-1H-BENZIMIDAZOL]-1'-YL)METHYL]-[1,1'-BIPHENYL]-2-CARBOXYLIC ACID
BIBR 277
MICARDIS®
rxcui:73494
chembl:CHEMBL1017
drugbank:00966
chemidplus:144701-48-4
pubchem.compound:65999

Drug Info:

Drug Class	antihypertensive agents
Year of Approval	1998
FDA Approval	not approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent

(3 More Sources)

Publications:

McClellan et al., 1998, Telmisartan., Drugs
Yamagishi et al., 2007, Potential utility of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-modulating activity for the treatment of cardiometabolic disorders., Curr. Mol. Med.
Yamagishi et al., 2005, Telmisartan is a promising cardiometabolic sartan due to its unique PPAR-gamma-inducing property., Med. Hypotheses
Tagami et al., 2009, A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones., Endocrinology
Strohmenger et al., 1997, Effects of the AT1-selective angiotensin II antagonist, telmisartan, on hemodynamics and ventricular function after cardiopulmonary resuscitation in pigs., Resuscitation
Karlberg et al., 1999, Efficacy and safety of telmisartan, a selective AT1 receptor antagonist, compared with enalapril in elderly patients with primary hypertension. TEES Study Group., J. Hypertens.
Balt et al., 2001, Effect of the AT1-receptor antagonists losartan, irbesartan, and telmisartan on angiotensin II-induced facilitation of sympathetic neurotransmission in the rat mesenteric artery., J. Cardiovasc. Pharmacol.
Kurtz, 2008, Beyond the classic angiotensin-receptor-blocker profile., Nat Clin Pract Cardiovasc Med
Galzerano et al., 2010, New standards in hypertension and cardiovascular risk management: focus on telmisartan., Vasc Health Risk Manag
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Sharpe et al., 2001, Telmisartan: a review of its use in hypertension., Drugs
Gohlke et al., 2001, AT1 receptor antagonist telmisartan administered peripherally inhibits central responses to angiotensin II in conscious rats., J. Pharmacol. Exp. Ther.
Fujimoto et al., 2004, An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3-L1 adipocytes., FEBS Lett.
Imayama et al., 2006, Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma., Cardiovasc. Res.

TELMISARTAN AGTR1

Interaction Score: 3.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name telmisartan,Micardis, Micardis HCT

Novel drug target Established target

Mechanism of Interaction Type-1 angiotensin II receptor antagonist

PMIDs:
9878991 17691961 15617852 19147680 9259062 10067800 11444497 18580862 20448797 11752352 11558835 11408526 15498586 16938288

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
TELMISARTAN GNB3

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TELMISARTAN NPSR1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TELMISARTAN USP1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TELMISARTAN HSD17B10

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TELMISARTAN NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TELMISARTAN EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: TELMISARTAN
- Version: 01-August-2011
Alternate Names:

TELMISARTAN Primary Drug Name

Drug Info:

Year of Approval 1998

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: TELMISARTAN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval not approved

Publications:
DTC: TELMISARTAN
- Version: 02-September-2020
Alternate Names:

CHEMBL1017 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Telmisartan
- Version: 2020.06.01
Alternate Names:

D0N6RF TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1017
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1017
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
PharmGKB: telmisartan
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	telmisartan,Micardis, Micardis HCT
Novel drug target	Established target
Mechanism of Interaction	Type-1 angiotensin II receptor antagonist

TELMISARTAN Drug Record

TELMISARTAN chembl:CHEMBL1017 Approved

Alternate Names:

Drug Info:

Publications:

TELMISARTAN AGTR1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name telmisartan,Micardis, Micardis HCT Novel drug target Established target Mechanism of Interaction Type-1 angiotensin II receptor antagonist

PMIDs: 9878991 17691961 15617852 19147680 9259062 10067800 11444497 18580862 20448797 11752352 11558835 11408526 15498586 16938288

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

TELMISARTAN GNB3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

TELMISARTAN NPSR1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TELMISARTAN USP1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TELMISARTAN HSD17B10

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TELMISARTAN NFE2L2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TELMISARTAN EHMT2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: TELMISARTAN

Alternate Names: TELMISARTAN Primary Drug Name

Drug Info: Year of Approval 1998 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: TELMISARTAN

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval not approved

Publications:

DTC: TELMISARTAN

Alternate Names: CHEMBL1017 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Telmisartan

Alternate Names: D0N6RF TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1017

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1017

Alternate Names:

Drug Info:

Publications:

PharmGKB: telmisartan

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name telmisartan,Micardis, Micardis HCT

Novel drug target Established target

Mechanism of Interaction Type-1 angiotensin II receptor antagonist

PMIDs:
9878991 17691961 15617852 19147680 9259062 10067800 11444497 18580862 20448797 11752352 11558835 11408526 15498586 16938288

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

TELMISARTAN Primary Drug Name

Drug Info:

Year of Approval 1998

Drug Class antihypertensive agents

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval not approved

Alternate Names:

CHEMBL1017 ChEMBL Drug ID

Alternate Names:

D0N6RF TTD Drug ID