DGIdb - BRD4 Gene Record

BRD4 23476 Druggable GenomeClinically Actionable

Alternate Names:

23476
BROMODOMAIN CONTAINING 4
BRD4
CAP
HUNK1
HUNKI
MCAP
608749
13575
ENSG00000141867
OTTHUMG00000183252
O60885
9588
Bromodomain-containing protein 4
T40556

Gene Info:

Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.
Stathis A et al., 2016, Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628., Cancer Discov
Zhao L et al., 2015, Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization., J Med Chem
Engleson et al., 2006, Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy., BMC Cancer

CHEMBL2017291 BRD4

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25559428

Sources:
DTC
BIRABRESIB BRD4

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26976114

Sources:
CIViC TTD
CHEMBL52030 BRD4

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
APABETALONE BRD4

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MOLIBRESIB BRD4

Interaction Score: 2.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
ABBV-744 BRD4

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
AZD-5153 BRD4

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ESTAZOLAM BRD4

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
TRIAZOLAM BRD4

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
ALPRAZOLAM BRD4

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
MIDAZOLAM BRD4

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
DOCETAXEL BRD4

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16542442

Sources:
NCI

Ensembl: ENSG00000141867
- Version: 101_38
Alternate Names:

BRD4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

CIViC: BRD4

Version: 14-September-2020

Alternate Names:

23476 Entrez Gene ID

9588 CIViC Gene ID

Gene Info:

Publications:

Filippakopoulos et al., 2010, Selective inhibition of BET bromodomains., Nature

Stathis A et al., 2016, Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628., Cancer Discov

NCI: BRD4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Nagashima et al., 2007, Histone acetylation and subcellular localization of chromosomal protein BRD4 during mouse oocyte meiosis and mitosis., Mol. Hum. Reprod.

Engleson et al., 2006, Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy., BMC Cancer

DTC: BRD4

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Zhao L et al., 2015, Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization., J Med Chem

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.

HingoraniCasas: ENSG00000141867
- Version: 31-May-2017
Alternate Names:

ENSG00000141867 Gene Symbol

BRD4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Tempus: BRD4
- Version: 11-November-2018
Alternate Names:

BRD4 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: BRD4
- Version: 27-Jun-2013
Alternate Names:

23476 Gene ID

CAP dGene Synonym

HUNK1 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Bromodomain-containing protein 4
- Version: 2020.06.01
Alternate Names:

BRD4 TTD Gene Abbreviation

T40556 TTD Target ID

Gene Info:

Publications:
Pharos: BRD4
- Version: 01-February-2022
Alternate Names:

Bromodomain-containing protein 4 Gene Name

O60885 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: BRD4
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: BRD4
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: BRD4
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

BRD4 Gene Record

BRD4 23476 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25559428

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26976114

Sources: CIViC TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16542442

Sources: NCI

Ensembl: ENSG00000141867

Alternate Names: BRD4 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

CIViC: BRD4

Alternate Names: 23476 Entrez Gene ID 9588 CIViC Gene ID

Gene Info:

Publications: Filippakopoulos et al., 2010, Selective inhibition of BET bromodomains., Nature Stathis A et al., 2016, Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628., Cancer Discov

NCI: BRD4

Alternate Names:

Gene Info:

DTC: BRD4

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000141867

Alternate Names: ENSG00000141867 Gene Symbol BRD4 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Tempus: BRD4

Alternate Names: BRD4 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

dGene: BRD4

Alternate Names: 23476 Gene ID CAP dGene Synonym HUNK1 dGene Synonym

Interaction Types & Directionality:

n/a

PMIDs:
25559428

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26976114

Sources:
CIViC TTD

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16542442

Sources:
NCI

Alternate Names:

BRD4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

23476 Entrez Gene ID

9588 CIViC Gene ID

Publications:

Filippakopoulos et al., 2010, Selective inhibition of BET bromodomains., Nature

Stathis A et al., 2016, Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628., Cancer Discov

Alternate Names:

ENSG00000141867 Gene Symbol

BRD4 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

BRD4 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

23476 Gene ID

CAP dGene Synonym

HUNK1 dGene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE

Alternate Names:

BRD4 TTD Gene Abbreviation

T40556 TTD Target ID

Alternate Names:

Bromodomain-containing protein 4 Gene Name

O60885 UniProt ID

Gene Categories:

KINASE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE