DGIdb - ALPRAZOLAM Drug Record

ALPRAZOLAM chembl:CHEMBL661 Approved

Alternate Names:

U-31889
XANAX XR
ALPRAZOLAM
U 31,889
ALPRAZOLAM CIV
XANAX
NIRAVAM
NIRAVAM®
XANAX®
8-CHLORO-1-METHYL-6-PHENYL-4H-S-TRIAZOLO(4,3-A)(1,4)BENZODIAZEPINE
KENTIUM
ALZAM
drugbank:00404
chemidplus:28981-97-7
chembl:CHEMBL661
pubchem.compound:2118
rxcui:596

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	anxiolytic, sedative,hypnotic
Drug Class	anti-anxiety agents
Year of Approval	1981
Drug Class	hypnotics and sedatives

(4 More Sources)

Publications:

Verster et al., 2004, Clinical pharmacology, clinical efficacy, and behavioral toxicity of alprazolam: a review of the literature., CNS Drug Rev
Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.
Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature
Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem
Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.
Oda et al., 2002, Suppression of monocyte chemoattractant protein 1, but not IL-8, by alprazolam: effect of alprazolam on c-Rel/p65 and c-Rel/p50 binding to the monocyte chemoattractant protein 1 promoter region., J. Immunol.
Zastrozhin MS et al., 2020, Effects of plasma concentration of micro-RNA Mir-27b and CYP3A4*22 on equilibrium concentration of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder., Gene
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

ALPRAZOLAM BRDT

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
ALPRAZOLAM BRD3

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
ALPRAZOLAM BRD2

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
ALPRAZOLAM PBRM1

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
ALPRAZOLAM BRD4

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
ALPRAZOLAM CREBBP

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
ALPRAZOLAM GABRR2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
ALPRAZOLAM GABRR3

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
ALPRAZOLAM GABRA1

Interaction Score: 0.16

Interaction Types & Directionality:

ligand

positive modulator (activating)

allosteric modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Trial Name AZ-002, Staccato alprazolam

PMIDs:
14978513 18384456 29950725 23038269

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM TSPO

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND TTD
ALPRAZOLAM GABRQ

Interaction Score: 0.11

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRP

Interaction Score: 0.1

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name alprazolam,Xanax, Xanax XR

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRE

Interaction Score: 0.1

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRD

Interaction Score: 0.1

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name AZ-002, Staccato alprazolam

Novel drug target Established target

Trial Name alprazolam,Xanax, Xanax XR

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRB3

Interaction Score: 0.1

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRG1

Interaction Score: 0.1

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRB1

Interaction Score: 0.1

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRA4

Interaction Score: 0.09

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRA6

Interaction Score: 0.09

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name alprazolam,Xanax, Xanax XR

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRB2

Interaction Score: 0.09

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name alprazolam,Xanax, Xanax XR

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRG3

Interaction Score: 0.09

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRA5

Interaction Score: 0.08

Interaction Types & Directionality:

positive modulator (activating)

allosteric modulator

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRA3

Interaction Score: 0.08

Interaction Types & Directionality:

positive modulator (activating)

allosteric modulator

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRA2

Interaction Score: 0.08

Interaction Types & Directionality:

positive modulator (activating)

allosteric modulator

Interaction Info:

Trial Name AZ-002, Staccato alprazolam

Novel drug target Established target

Trial Name alprazolam,Xanax, Xanax XR

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPRAZOLAM GABRR1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AZ-002, Staccato alprazolam

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ALPRAZOLAM CXCL8

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12218154

Sources:
NCI
ALPRAZOLAM GABRG2

Interaction Score: 0.06

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TEND
ALPRAZOLAM CYP3A5

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
ALPRAZOLAM HPGD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALPRAZOLAM CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
32112986

Sources:
PharmGKB

TEND: ALPRAZOLAM
- Version: 01-August-2011
Alternate Names:

ALPRAZOLAM Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval 1981

Drug Class anti-anxiety agents

Publications:
TdgClinicalTrial: ALPRAZOLAM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications anxiolytic, sedative,hypnotic

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: ALPRAZOLAM

Version: 14-September-2017

Alternate Names:

C227 NCI drug code

Drug Info:

Publications:

Oda et al., 2002, Suppression of monocyte chemoattractant protein 1, but not IL-8, by alprazolam: effect of alprazolam on c-Rel/p65 and c-Rel/p50 binding to the monocyte chemoattractant protein 1 promoter region., J. Immunol.

DTC: ALPRAZOLAM
- Version: 02-September-2020
Alternate Names:

CHEMBL661 ChEMBL Drug ID

Drug Info:

Publications:

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.

PharmGKB: alprazolam

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Zastrozhin MS et al., 2020, Effects of plasma concentration of micro-RNA Mir-27b and CYP3A4*22 on equilibrium concentration of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder., Gene

TTD: Alprazolam
- Version: 2020.06.01
Alternate Names:

D0L9GG TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL661
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL661
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	alprazolam,Xanax, Xanax XR
Novel drug target	Established target
Trial Name	AZ-002, Staccato alprazolam

Direct Interaction	yes
Mechanism of Interaction	GABA-A receptor; anion channel positive allosteric modulator
Trial Name	AZ-002, Staccato alprazolam

ALPRAZOLAM Drug Record

ALPRAZOLAM chembl:CHEMBL661 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name alprazolam,Xanax, Xanax XR Novel drug target Established target Trial Name AZ-002, Staccato alprazolam

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name alprazolam,Xanax, Xanax XR Novel drug target Established target Trial Name AZ-002, Staccato alprazolam

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: ligand positive modulator (activating) allosteric modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Trial Name AZ-002, Staccato alprazolam

PMIDs: 14978513 18384456 29950725 23038269

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND TTD

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Trial Name alprazolam,Xanax, Xanax XR Novel drug target Established target Trial Name AZ-002, Staccato alprazolam

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes Trial Name alprazolam,Xanax, Xanax XR

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Trial Name alprazolam,Xanax, Xanax XR Novel drug target Established target Trial Name AZ-002, Staccato alprazolam

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Trial Name AZ-002, Staccato alprazolam Novel drug target Established target Trial Name alprazolam,Xanax, Xanax XR

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes Trial Name AZ-002, Staccato alprazolam

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Trial Name alprazolam,Xanax, Xanax XR Novel drug target Established target Trial Name AZ-002, Staccato alprazolam

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Trial Name alprazolam,Xanax, Xanax XR Novel drug target Established target Trial Name AZ-002, Staccato alprazolam

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Trial Name alprazolam,Xanax, Xanax XR Novel drug target Established target Trial Name AZ-002, Staccato alprazolam

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes Trial Name alprazolam,Xanax, Xanax XR

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

ligand

positive modulator (activating)

allosteric modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Trial Name AZ-002, Staccato alprazolam

PMIDs:
14978513 18384456 29950725 23038269

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND TTD

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name alprazolam,Xanax, Xanax XR

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name AZ-002, Staccato alprazolam

Novel drug target Established target

Trial Name alprazolam,Xanax, Xanax XR

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name alprazolam,Xanax, Xanax XR

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name alprazolam,Xanax, Xanax XR

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

positive modulator (activating)

allosteric modulator

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found